Pyrrolidines
Pyrrolidines are a class of heterocyclic compounds characterized by the presence of a five-membered ring containing one nitrogen atom. Widely used in organic synthesis, these secondary amines exhibit unique chemical properties that make them versatile building blocks for various pharmaceuticals and agrochemicals. Pyrrolidines can be synthesized through several methods, including amidolysis of cyclic carbonates or ureides, as well as by the reduction of pyrroles. Their amine functionality allows for facile derivatization, making them valuable in the development of drugs targeting a wide range of biological pathways. Additionally, their hydrophilic nature and low toxicity contribute to their application in both drug design and functional materials.
| Structure | Chemical Name | CAS | MF |
|---|---|---|---|
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Octahydropyrrolo[3,4-C]pyrrole | 5840-00-6 | C6H12N2 |
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(3S)-N-Methyl-3-pyrrolidinamine | 139015-32-0 | C5H12N2 |
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2-(Methoxymethyl)pyrrolidine | 76946-27-5 | C6H13NO |
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N-(pyrrolidin-3-yl)acetamide | 79286-74-1 | C6H12N2O |
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tert-butyl N-[(3S,5S)-5-(hydroxymethyl)pyrrolidin-3-yl]carbamate | 663948-85-4 | C10H20N2O3 |
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(3R)-3-fluoropyrrolidine | 679431-51-7 | C4H8FN |
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3-(Methylamino)pyrrolidine | 83030-08-4 | C5H12N2 |
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(3S,4S)-Pyrrolidine-3,4-diol | 90481-32-6 | C4H9NO2 |
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tert-butyl N-pyrrolidin-3-ylcarbamate | 99724-19-3 | C9H18N2O2 |
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(S)-3-Hydroxypyrrolidine | 100243-39-8 | C4H9NO |
Related Literature
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Jason Y. C. Lim,Yong Yu,Guorui Jin,Kai Li,Yi Lu,Jianping Xie Nanoscale Adv., 2020,2, 3921-3932
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Gang Pan,Yi-jie Bao,Jie Xu,Tao Liu,Cheng Liu,Yan-yan Qiu,Xiao-jing Shi,Hui Yu,Ting-ting Jia,Xia Yuan,Ze-ting Yuan,Yi-jun Cao RSC Adv., 2016,6, 42109-42119
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Ross Harder,David C. Dunand,Ian McNulty Nanoscale, 2017,9, 5686-5693
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Albertus D. Handoko,Khoong Hong Khoo,Teck Leong Tan,Hongmei Jin,Zhi Wei Seh J. Mater. Chem. A, 2018,6, 21885-21890
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