Primary carboxylic acid amides
Primary carboxylic acid amides are a class of organic compounds that feature an amide functional group attached to a primary (1°) carbon atom. These molecules are widely used in various applications due to their versatile chemical properties and structural diversity. Typically, they can be derived from the reaction between a carboxylic acid and an amine where one hydrogen atom on the amine is replaced by the carboxyl group.
Primary carboxylic acid amides exhibit excellent solubility in polar solvents and poor solubility in non-polar organic solvents, which makes them suitable for applications requiring specific solubility characteristics. They are often employed as intermediates in pharmaceuticals, agrochemicals, and polymer synthesis. Additionally, these compounds can act as stabilizers, surfactants, or crosslinking agents due to their amide functionality.
Structurally, the presence of a carboxyl group allows for potential derivatization, enhancing their reactivity and enabling the formation of various esters, anhydrides, and other derivatives. Primary carboxylic acid amides are also known for their ability to form hydrogen bonds, contributing to their biological activity in certain contexts.
Overall, primary carboxylic acid amides represent a valuable class of molecules with wide-ranging applications across multiple industries, driven by their unique chemical properties and functional diversity.
| Structure | Chemical Name | CAS | MF |
|---|---|---|---|
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2,2-Dichloroacetamide | 683-72-7 | C2H3Cl2NO |
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Propanamide,3-(methylthio)- | 22551-25-3 | C4H9NOS |
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6,8-Dimethyl-2,4,6-decatrienoic acid; (2E,4E,6E,8ξ)-form, Amide | 1572624-25-9 | C12H19NO |
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(E)-oct-4-en-2-ynamide | 1356929-26-4 | C8H11NO |
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(Z)-oct-6-ene-2,4-diynamide | 1356929-28-6 | C8H7NO |
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pestalotiopamide A | 1263054-80-3 | C8H13NO3 |
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2-Cyanoacetamide | 107-91-5 | C3H4N2O |
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2,4-Hexadienamide,4-ethyl-, (E,E)- (9CI) | 92454-24-5 | C8H13NO |
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2-Methyl-d3-propionic-3,3,3-d3-amide | 1020719-64-5 | C4H9NO |
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(Z)-2-methyl-2-butenamide | 5953-75-3 | C5H9NO |
Related Literature
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Brindha J.,Balamurali M. M.,Kaushik Chanda RSC Adv., 2019,9, 34720-34734
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Abdelaziz Houmam,Emad M. Hamed Chem. Commun., 2012,48, 11328-11330
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Guiying Zhang,Maosheng Cheng,Yanni Li,Keliang Liu,Lifeng Cai Chem. Commun., 2013,49, 11086-11088
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Domenico Lombardo,Gianmarco Munaò,Pietro Calandra,Luigi Pasqua,Maria Teresa Caccamo Phys. Chem. Chem. Phys., 2019,21, 11983-11991
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Xiaoming Liu,Zachary D. Hood,Wangda Li,Donovan N. Leonard,Arumugam Manthiram,Miaofang Chi J. Mater. Chem. A, 2021,9, 2111-2119
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