N-acyl amines
N-Acyl amines are a class of organic compounds that contain both an amine group (-NH?) and an acyl group (R'-CO-) attached to the same nitrogen atom. These functionalized molecules exhibit diverse chemical properties, making them valuable intermediates in various synthetic reactions. N-Acyl amines find extensive applications in pharmaceuticals, agrochemicals, and as precursors for other functional groups due to their reactivity towards nucleophiles and electrophiles.
Structurally, they are often derived from primary or secondary amines through acylation reactions using carboxylic acids or derivatives. The presence of the acyl group can influence the basicity and solubility of these compounds, offering a versatile platform for medicinal chemistry and material science applications. For instance, N-acyl amine derivatives are used in the synthesis of prodrugs, as ligands for metal complexes, and as intermediates in polymer synthesis.
In summary, N-acyl amines represent a structurally diverse group of compounds with broad utility across multiple sectors due to their unique chemical properties and reactivity.
| Structure | Chemical Name | CAS | MF |
|---|---|---|---|
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Octanamide, 4-hydroxy-N-methyl- | 57753-55-6 | C9H19NO2 |
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N,N,3-trimethylbutanamide | 5370-28-5 | C7H15NO |
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Tridecanamide, N-ethyl-N-methyl- | 59570-01-3 | C16H33NO |
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2-Octadecenamide, N-[(1S)-2-(acetyloxy)-1-methylethyl]-2-methyl-, (2E)- | 630100-45-7 | C24H45NO3 |
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2-Hexadecenamide, N-[(1S)-2-hydroxy-1-methylethyl]-2-methyl-, (2E)- | 630100-43-5 | C20H39NO2 |
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Tetradecanamide,N,N-bis(2-hydroxyethyl)- | 7545-23-5 | C18H37NO3 |
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Pentanamide,N,N-dimethyl-5-oxo- | 381230-85-9 | C7H13NO2 |
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Tetradecanamide,N,N-dimethyl- | 3015-65-4 | C16H33NO |
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N,N-Dimethylhexadecanamide | 3886-91-7 | C18H37NO |
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Pentadecanamide, N-(2-phenylethyl)- | 921607-16-1 | C23H39NO |
Related Literature
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Dhamodaran Manikandan,S. Amirthapandian,I. S. Zhidkov,A. I. Kukharenko,S. O. Cholakh,Ramaswamy Murugan Phys. Chem. Chem. Phys., 2018,20, 6500-6514
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Stephen P. Fletcher,Richard B. C. Jagt,Ben L. Feringa Chem. Commun., 2007, 2578-2580
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Chongyang Zhu,Xiaojia Bian,Xin Jia,Ning Tang,Yongqiang Cheng Food Funct., 2020,11, 10635-10644
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Piotr Szcze?niak,Sebastian Stecko RSC Adv., 2015,5, 30882-30888
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Alvin Tanudjaja,Shinsuke Inagi,Fusao Kitamura,Toshikazu Takata,Ikuyoshi Tomita Dalton Trans., 2021,50, 3037-3043
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