Cedrane and Isocedrane sesquiterpenoids are a class of natural products isolated from the wood of Cedrus spp., primarily characterized by their complex structural features. These compounds exhibit significant pharmacological activities, including antimicrobial, anti-inflammatory, and antioxidant properties. Structurally, Cedrane (also known as cedrol) is a monocyclic sesquiterpene alcohol with a bicyclic structure, while Isocedrane possesses a similar but slightly modified molecular framework. Both compounds are widely recognized for their potential applications in pharmaceuticals and cosmetics due to their versatile biological activities. Notably, Cedrane has been used as a fragrance component and flavoring agent owing to its distinctive scent. Research on these sesquiterpenoids continues to explore new therapeutic potentials and enhance our understanding of their molecular mechanisms.