Angular furanocoumarins are a class of natural products found in various plants, particularly in members of the Umbelliferae family such as psoralens. These compounds exhibit unique angular furocoumarin structures, characterized by the fusion of a benzene ring with a furan ring at an angle, hence their name. Furanocoumarins play crucial roles in plant biology and are known for their photosensitizing properties. In the context of pharmaceuticals, angular furanocoumarins have been explored for their potential as anti-inflammatory agents and antimicrobial compounds due to their ability to interact with DNA upon exposure to ultraviolet light. However, these compounds can also cause phototoxicity, leading to skin irritation or burns if exposed to sunlight. Their structure-activity relationships are of particular interest in the development of new therapeutic agents. Research into furanocoumarins continues as scientists seek to harness their biological activities while mitigating adverse effects.