Cas no 5058-13-9 (Columbianadin)
Columbianadin is a bioactive coumarin derivative primarily isolated from Angelica pubescens and related species. It exhibits notable pharmacological properties, including anti-inflammatory, vasodilatory, and neuroprotective effects. Structurally, it features a furanocoumarin backbone, contributing to its interaction with cellular targets such as calcium channels and inflammatory mediators. Studies highlight its potential in mitigating oxidative stress and modulating neurotransmitter activity, suggesting therapeutic relevance for cardiovascular and neurological disorders. Its dual mechanism—combining antioxidant capacity with calcium channel modulation—distinguishes it from simpler coumarins. Columbianadin's stability and bioavailability in vitro further support its investigational use in drug development. Research continues to explore its structure-activity relationship for optimized efficacy.
Columbianadin structure
Product Name:Columbianadin
CAS No:5058-13-9
MF:C19H20O5
MW:328.359106063843
MDL:MFCD07781426
CID:45505
PubChem ID:354335572
Update Time:2025-07-02
Columbianadin Chemical and Physical Properties
Names and Identifiers
-
- Columbianadin
- (S)-8-[1-[(Z)-2-Methyl-2-butenoyloxy]-1-methylethyl]-8,9-dihydro-2H-furo[2,3-h]-1-benzopyran-2-one
- 2-Butenoic acid,2-methyl-,1-[(8S)-8,9-dihydro-2-oxo-2H-furo[2,3-h]-1-benzopyran-8-yl]-1-methylethylester, (2Z)-
- Columbianedin
- 8-O-angeloyl-8,9-dihydrooroselol
- ColuMbianin
- ZosiMin
- (Z)-2-Methylbut-2-enoic Acid (S)-2-(2-Oxo-8,9-dihydro-2H-furo[2,3-h]chromen-8-yl)propan-2-yl Ester
- (S)-2-(2-Oxo-8,9-dihydro-2H-furo[2,3-h]chromen-8-yl)propan-2-yl (Z)-2-Methylbut-2-enoate
- MLS000574825
- 2-[(8S)-2-oxo-8,9-dihydrofuro[2,3-h]chromen-8-yl]propan-2-yl (Z)-2-methylbut-2-enoate
- HMS2218E06
- SMR000156217
- AB0028983
- X1109
- N2424
- C3479
- 058C139
- 2-Butenoic acid,2-methyl-,1-[(8S)-8,9-dihydro-2-oxo-2H-furo[2,3-h]-1-benzopy
- s9017
- ZB1858
- 2-Butenoic acid, 2-methyl-, 1-(8,9-dihydro-2-oxo-2H-furo(2,3-h)-1-benzopyran-8-yl)-1-methylethyl ester, (S-(Z))-
- (S,Z)-2-(2-oxo-8,9-dihydro-2H-furo[2,3-h]chromen-8-yl)propan-2-yl 2-methylbut-2-enoate
- CCG-267789
- Q-100567
- 2-Butenoic acid, 2-methyl-, 1-(8,9-dihydro-2-oxo-2H-furo(2,3-h)-1-benzopyran-8-yl)-1-methylet- hyl ester, (S-(Z))-
- BS-42416
- A871516
- AC-34185
- HY-N0362
- CHEMBL1324067
- DTXSID401317565
- [1-methyl-1-[(8S)-2-oxo-8,9-dihydrofuro[2,3-h]chromen-8-yl]ethyl] (Z)-2-methylbut-2-enoate
- NCGC00247538-01
- 2-[(8S)-2-oxo-8,9-dihydro-2H-furo[2,3-h][1]benzopyran-8-yl]propan-2-yl (2Z)-2-methylbut-2-enoate
- 5058-13-9
- AKOS030573517
- CS-7661
- MFCD07781426
- CHEBI:132624
- DA-72314
- 2-((8S)-2-oxo-8,9-dihydro-2H-furo(2,3-h)(1)benzopyran-8-yl)propan-2-yl (2Z)-2-methylbut-2-enoate
-
- MDL： MFCD07781426
- Inchi： 1S/C19H20O5/c1-5-11(2)18(21)24-19(3,4)15-10-13-14(22-15)8-6-12-7-9-16(20)23-17(12)13/h5-9,15H,10H2,1-4H3/b11-5-/t15-/m0/s1
- InChI Key： JRIBPWOXWIRQOQ-GHAIFCDISA-N
- SMILES： O1C2C=CC3C=CC(=O)OC=3C=2C[C@H]1C(C)(C)OC(/C(=C\C)/C)=O
Computed Properties
- Exact Mass: 328.13100
- Monoisotopic Mass: 328.13107373 g/mol
- Isotope Atom Count: 0
- Hydrogen Bond Donor Count: 0
- Hydrogen Bond Acceptor Count: 5
- Heavy Atom Count: 24
- Rotatable Bond Count: 4
- Complexity: 589
- Covalently-Bonded Unit Count: 1
- Defined Atom Stereocenter Count: 1
- Undefined Atom Stereocenter Count : 0
- Defined Bond Stereocenter Count: 1
- Undefined Bond Stereocenter Count: 0
- Molecular Weight: 328.4
- XLogP3: 3.7
- Topological Polar Surface Area: 61.8
Experimental Properties
- Color/Form: Powder
- Melting Point: 117.0 to 121.0 deg-C
- Boiling Point: 482.3±45.0 °C at 760 mmHg
- Flash Point: 212.7±28.8 °C
- PSA: 65.74000
- LogP: 3.38450
Columbianadin Security Information
- Signal Word：warning
- Hazard Statement： H303May be harmful if swallowed+H313Skin contact may be harmful+H333Inhalation may be harmful to the body
-
Warning Statement：
P264Thoroughly clean after treatment
P280Wear protective gloves/Wear protective clothing/Wear protective goggles/Wear a protective mask
P305If it enters the eyes
P351Rinse carefully with water for a few minutes
P338Remove the contact lens(If any)And easy to operate,Continue flushing
P337If eye irritation persists
P313Obtain medical advice/care - Safety Instruction： 24/25
- Storage Condition：Powder -20°C 3 years ? 4°C 2 years In solvent -80°C 6 months ? -20°C 1 month
Columbianadin Pricemore >>
| Related Categories | No. | Product Name | Cas No. | Purity | Specification | Price | update time | Inquiry |
|---|---|---|---|---|---|---|---|---|
| SHANG HAI XIAN DING Biotechnology Co., Ltd. | C3479-25mg |
Columbianadin |
5058-13-9 | 98.0%(LC) | 25mg |
￥1990.0 | 2022-06-09 | |
| SHANG HAI XIAN DING Biotechnology Co., Ltd. | C3479-100mg |
Columbianadin |
5058-13-9 | 98.0%(LC) | 100mg |
￥4990.0 | 2022-06-09 | |
| Chengdu Biopurify Phytochemicals Ltd | BP0381-20mg |
Columbianadin |
5058-13-9 | 98% | 20mg |
$55 | 2023-09-20 | |
| Chengdu Biopurify Phytochemicals Ltd | BP0381-100mg |
Columbianadin |
5058-13-9 | 98% | 100mg |
$220 | 2023-09-20 | |
| WU HAN AN JIE KAI Biomedical Technology Co., Ltd. | ajcn4488-20mg |
Columbianadin |
5058-13-9 | 98% | 20mg |
￥2896.00 | 2023-09-07 | |
| SHANG HAI TAO SHU Biotechnology Co., Ltd. | T3373-2 mg |
Columbianadin |
5058-13-9 | 98.44% | 2mg |
￥311.00 | 2022-04-26 | |
| SHANG HAI TAO SHU Biotechnology Co., Ltd. | T3373-5 mg |
Columbianadin |
5058-13-9 | 98.44% | 5mg |
￥560.00 | 2022-04-26 | |
| SHANG HAI TAO SHU Biotechnology Co., Ltd. | T3373-10 mg |
Columbianadin |
5058-13-9 | 98.44% | 10mg |
￥815.00 | 2022-04-26 | |
| SHANG HAI TAO SHU Biotechnology Co., Ltd. | T3373-25 mg |
Columbianadin |
5058-13-9 | 98.44% | 25mg |
￥1665.00 | 2022-04-26 | |
| SHANG HAI TAO SHU Biotechnology Co., Ltd. | T3373-50 mg |
Columbianadin |
5058-13-9 | 98.44% | 50mg |
￥2770.00 | 2022-04-26 |
Columbianadin Suppliers
Amadis Chemical Company Limited
Gold Member
Audited Supplier
(CAS:5058-13-9)Columbianadin
Order Number:A871516
Stock Status:in Stock
Quantity:100mg/10mg
Purity:99%
Pricing Information Last Updated:Friday, 30 August 2024 09:29
Price ($):375.0/169.0
Email:[email protected]
Suzhou Senfeida Chemical Co., Ltd
Gold Member
Audited Supplier
(CAS:5058-13-9)Columbianadin
Order Number:sfd19903
Stock Status:in Stock
Quantity:200kg
Purity:99.9%
Pricing Information Last Updated:Friday, 19 July 2024 14:38
Price ($):discuss personally
Email:[email protected]
Columbianadin Related Literature
-
Tengfei Yu,Yuehan Wu,Wei Li,Bin Li RSC Adv., 2014,4, 34134-34143
-
Jason Wan Lab Chip, 2020,20, 4528-4538
-
Shintaro Takata,Yoshihiro Miura Phys. Chem. Chem. Phys., 2014,16, 24784-24789
-
Aloke Das,K. K. Mahato,Chayan K. Nandi,Tapas Chakraborty,Shridhar R. Gadre,Nikhil A. Gokhale Phys. Chem. Chem. Phys., 2002,4, 2162-2168
5058-13-9 (Columbianadin) Related Products
- 3804-70-4((+)-Columbianetin)
- 14882-94-1(7H-Furo(3,2-g)(1)benzopyran-7-one, 2-(1-(acetyloxy)-1-methylethyl)-6-(1,1-dimethyl-2-propenyl)-2,3-dihydro-)
- 150135-35-6(2-Butenoic acid,2-methyl-,(9R,10R)-9,10-dihydro-9-hydroxy-8,8-dimethyl-2-oxo-2H,8H-benzo[1,2-b:3,4-b']dipyran-10-ylester, (2E)- (9CI))
- 13849-08-6(S-(+)-Marmesin)
- 81740-07-0(Praeruptorin B)
- 130848-06-5(Decursinol angelate)
- 15591-75-0(2-Butenoic acid,2-methyl-,(8S,9R)-8-[1-(acetyloxy)-1-methylethyl]-8,9-dihydro-2-oxo-2H-furo[2,3-h]-1-benzopyran-9-ylester, (2Z)-)
- 73069-27-9(Praeruptorin A)
- 23180-65-6((+)-Columbianetin acetate)
- 13161-75-6(Pteryxin)
