Alpha-chloroketones
Alpha-chloroketones are a class of organic compounds characterized by the presence of a chlorine atom attached to the alpha carbon of a ketone group (C=O). These chemicals play significant roles in various applications due to their unique reactivity and functionality. Typically, they are synthesized through chlorination reactions involving ketones or aldehydes, often utilizing Lewis acids as catalysts.
The α-chloroketones exhibit diverse chemical properties, including moderate acidity and electrophilicity, which make them valuable intermediates in organic synthesis. They find extensive use in the pharmaceutical industry for the production of drugs such as analgesics, anti-inflammatories, and other therapeutic agents. Additionally, these compounds are utilized in agrochemicals to develop herbicides and pesticides.
Furthermore, alpha-chloroketones are important precursors in the manufacture of fragrances, polymers, and dyes due to their ability to undergo various transformations. Their reactivity can be further manipulated through functional group modifications, making them versatile building blocks for complex molecular structures.
| Structure | Chemical Name | CAS | MF |
|---|---|---|---|
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2-Propanone, 1,1-dibromo-3,3-dichloro- | 62874-83-3 | C3H2Br2Cl2O |
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2-Propanone, 1-bromo-1,3,3-trichloro- | 62874-82-2 | C3H2BrCl3O |
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1,1,3-Trichloroacetone | 921-03-9 | C3H3Cl3O |
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2-Propanone, 3-bromo-1,1-dichloro- | 1578-16-1 | C3H3BrCl2O |
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2-Propanone, 1-bromo-1,3-dichloro- | 1578-17-2 | C3H3BrCl2O |
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4-Hydroxy-3-(1-propenyl)-2-cyclopenten-1-one; (S,E)-form, 2-Chloro | 1878152-09-0 | C8H9ClO2 |
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2-Propanone, 1-chloro-3-iodo- | 62874-85-5 | C3H4ClIO |
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2-Propanone, 1,3-dibromo-1,3-dichloro- | 62874-84-4 | C3H2Br2Cl2O |
Related Literature
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Brindha J.,Balamurali M. M.,Kaushik Chanda RSC Adv., 2019,9, 34720-34734
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Liao Xiaoqing,Li Ruiyi,Li Zaijun,Sun Xiulan,Wang Zhouping,Liu Junkang New J. Chem., 2015,39, 5240-5248
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Albertus D. Handoko,Khoong Hong Khoo,Teck Leong Tan,Hongmei Jin,Zhi Wei Seh J. Mater. Chem. A, 2018,6, 21885-21890
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Guiying Zhang,Maosheng Cheng,Yanni Li,Keliang Liu,Lifeng Cai Chem. Commun., 2013,49, 11086-11088
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Matthew J. Gaunt,Jinquan Yu,Jonathan B. Spencer Chem. Commun., 2001, 1844-1845
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