• 1. Fe/Fe3C@C nanoparticles encapsulated in N-doped graphene–CNTs framework as an efficient bifunctional oxygen electrocatalyst for robust rechargeable Zn–air batteries?
  Zhiyan Chen,Nan Wu,Yaobing Wang,Bing Wang,Yingde Wang J. Mater. Chem. A, 2018,6, 516-526
• 2. Embedding cyclic nitrone in mesoporous silica particles for EPR spin trapping of superoxide and other radicals?
  Eric Besson,Stéphane Gastaldi,Emily Bloch,Selma Aslan,Hakim Karoui,Olivier Ouari,Micael Hardy Analyst, 2019,144, 4194-4203
• 3. Excellent lithium ion storage property of porous MnCo2O4 nanorods?
  Peiyuan Zeng,Xiaoxiao Wang,Ming Ye,Qiuyang Ma,Jianwen Li,Wanwan Wang,Baoyou Geng,Zhen Fang RSC Adv., 2016,6, 23074-23084
• 4. Excitation energies from ground-state density-functionals by means of generator coordinates
  A. B. F. da Silva,K. Capelle Phys. Chem. Chem. Phys., 2009,11, 4564-4569
• 5. Enabling high-throughput single-animal gene-expression studies with molecular and micro-scale technologies
  Jason Wan Lab Chip, 2020,20, 4528-4538

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Indoles and derivatives Indoles

Recent Advances in the Study of 4,6-Dibromo-1H-indole (CAS: 99910-50-6) in Chemical Biology and Pharmaceutical Research

4,6-Dibromo-1H-indole (CAS: 99910-50-6) is a halogenated indole derivative that has garnered significant attention in recent years due to its versatile applications in chemical biology and pharmaceutical research. This compound serves as a key intermediate in the synthesis of various bioactive molecules, including potential drug candidates. Its unique structural features, characterized by the presence of bromine atoms at the 4 and 6 positions of the indole ring, make it a valuable scaffold for medicinal chemistry and drug discovery efforts.

Recent studies have highlighted the role of 4,6-Dibromo-1H-indole in the development of novel therapeutic agents. For instance, researchers have explored its utility as a building block for the synthesis of indole-based kinase inhibitors, which are of particular interest in oncology. The bromine substituents on the indole ring provide reactive sites for further functionalization, enabling the creation of diverse chemical libraries for high-throughput screening. Additionally, its potential as a precursor for fluorescent probes has been investigated, owing to the indole core's inherent photophysical properties.

In a 2023 study published in the Journal of Medicinal Chemistry, scientists demonstrated the efficacy of 4,6-Dibromo-1H-indole-derived compounds in targeting protein-protein interactions (PPIs) involved in cancer progression. The researchers utilized a structure-based drug design approach to modify the indole scaffold, resulting in compounds with improved binding affinity and selectivity. These findings underscore the compound's potential as a versatile tool in the development of next-generation therapeutics.

Another area of active research involves the use of 4,6-Dibromo-1H-indole in the synthesis of antimicrobial agents. A recent publication in Bioorganic & Medicinal Chemistry Letters reported the synthesis of a series of indole derivatives with potent activity against multidrug-resistant bacterial strains. The study emphasized the importance of the bromine atoms in enhancing the compounds' bioavailability and membrane permeability, which are critical factors in antimicrobial drug development.

Beyond its pharmaceutical applications, 4,6-Dibromo-1H-indole has also been investigated in materials science. Researchers have explored its incorporation into organic semiconductors and optoelectronic materials, leveraging the indole moiety's electron-rich nature. This interdisciplinary approach highlights the compound's broad utility across multiple scientific domains.

In conclusion, 4,6-Dibromo-1H-indole (CAS: 99910-50-6) continues to be a focal point in chemical biology and pharmaceutical research. Its structural versatility, combined with its potential therapeutic and material applications, makes it a valuable compound for ongoing and future studies. As research progresses, further insights into its mechanisms of action and optimization strategies are expected to emerge, paving the way for innovative applications in drug discovery and beyond.

• 3964-04-3(4-Bromoquinoline)
• 74076-58-7(1H-Indole,3,4,6-tribromo-)
• 4964-71-0(5-Bromoquinoline)
• 111181-01-2(11H-Benzo[a]carbazole, 5-bromo-)
• 34522-69-5(5,7-Dibromoquinoline)
• 136630-39-2(2,7-Dibromocarbazole)
• 3652-90-2(2-Bromo-9H-carbazole)
• 52415-29-9(6-Bromoindole)
• 52488-36-5(4-Bromo-1H-indole)
• 700871-88-1(4,7-Dibromoquinoline)