Cas no 99755-59-6 (Rotigotine)
Rotigotine is a non-ergoline dopamine agonist used primarily for the treatment of Parkinson's disease and restless legs syndrome. Its key advantage lies in its continuous delivery via transdermal patch, ensuring stable plasma concentrations and minimizing fluctuations associated with oral administration. This sustained-release mechanism enhances patient compliance and reduces side effects such as nausea and sudden drowsiness. Rotigotine exhibits high affinity for dopamine D3, D2, and D1 receptors, providing effective symptomatic relief. Its lipophilic nature facilitates efficient skin absorption, while its once-daily application simplifies dosing regimens. The compound's broad receptor activity may also offer benefits in managing both motor and non-motor symptoms of Parkinson's disease.
Rotigotine structure
Product Name:Rotigotine
CAS No:99755-59-6
MF:C19H25NOS
MW:315.472903966904
MDL:MFCD00870193
CID:62103
PubChem ID:59227
Update Time:2025-06-09
Rotigotine Chemical and Physical Properties
Names and Identifiers
-
- Rotigotine
- (-)-(S)-5,6,7,8-Tetrahydro-6-(propyl(2-(2-thienyl)ethyl)amino)-1-naphthol
- (S)-6-(Propyl(2-(thiophen-2-yl)ethyl)amino)-5,6,7,8-tetrahydronaphthalen-1-ol
- [14C]-Rotigotine
- 1-Naphthalenol, 5,6,7,8-tetrahydro-6-[propyl[2-(2-thienyl)ethyl]amino]-,(6S)-
- (S)-6-[Propyl[2-(thiophen-2-yl)ethyl]amino]-5,6,7,8-tetrahydronaphthalen-1-ol
- (S)-5,6,7,8-Tetrahydro-6-(propyl(2-(2-thienyl)ethyl)amino)-1-naphthol
- Neupro
- Leganto
- Rotigotine CDS Patch
- SPM 962
- (6S)-rotigotine
- N 0923
- C19H25NOS
- 87T4T8BO2E
- (6S)-6-[propyl(2-thiophen-2-ylethyl)amino]-5,6,7,8-tetrahydronaphthalen-1-ol
- (6S)-6-(Propyl(2-(2-thienyl)ethyl)amino)-5,6,7,8-tetrahydro-1-naphthalenol
- DSSTox_RID_81893
- DSSTox_CID_26772
- D
- Q411985
- ROTIGOTINE [ORANGE BOOK]
- (-)-N-0437
- R0220
- s4274
- (6s)-5,6,7,8-tetrahydro-6-[propyl[2-(2-thienyl)ethyl]amino]-1-naphthalenol
- UNII-5QTR54Z0E1
- SPM-936
- AC-3547
- UNII-87T4T8BO2E
- Rotigotine [INN]
- MFCD00870193
- ROTIGOTINE [MART.]
- ROTIGOTINE [VANDF]
- SPM-937
- 99755-59-6 (free base)
- 6-(Propyl(2-(2-thienyl)ethyl)amino)-5,6,7,8-tetrahydro-1-naphthalenol
- Neupro (TN)
- BDBM50123626
- ROTIGOTINE [USP MONOGRAPH]
- CS-0376
- 1-NAPHTHALENOL, 5,6,7,8-TETRAHYDRO-6-(PROPYL(2-(2-THIENYL)ETHYL)AMINO-(6S)-
- EN300-26189697
- Tox21_112627_1
- ROTIGOTINE (MART.)
- (6S)-6-(propyl-(2-thiophen-2-ylethyl)amino)-5,6,7,8-tetrahydronaphthalen-1-ol
- (6~{S})-6-[propyl(2-thiophen-2-ylethyl)amino]-5,6,7,8-tetrahydronaphthalen-1-ol
- ROTIGOTINE [USAN]
- SS-4572
- N-0437
- Rotigotina
- 1-naphthalenol, 5,6,7,8-tetrahydro-6-(propyl (2-(2-thienyl)ethyl)amino-(6S)-
- 99755-59-6
- EX-A1164
- ROTIGOTINE [WHO-DD]
- CCG-267650
- (2S)-2-[propyl-[2-(2-thienyl)ethyl]amino]tetralin-5-ol
- ROTIGOTINE (USP-RS)
- CAS-99755-59-6
- Rotigotine [USAN:INN:BAN]
- SPM-962
- rotigotinum
- AKOS016340728
- ROTIGOTINE [EP MONOGRAPH]
- SCHEMBL1088585
- DTXSID5046772
- CHEBI:135351
- ROTIGOTINE [EMA EPAR]
- GTPL941
- (6S)-6-(Propyl(2-(thiophen-2-yl)ethyl)amino)-5,6,7,8-tetrahydronaphthalen-1-ol
- Rotigotine CDS
- SW220014-1
- (6S)-6-{propyl[2-(thiophen-2-yl)ethyl]amino}-5,6,7,8-tetrahydronaphthalen-1-ol
- KFQYTPMOWPVWEJ-INIZCTEOSA-N
- NS00122814
- CHEMBL1303
- ROTIGOTINE [JAN]
- HY-75502
- HMS3885D17
- D05768
- HSDB 8254
- NCGC00168748-01
- Tox21_112627
- Rotigotine (JAN/USAN/INN)
- ROTIGOTINE (USP MONOGRAPH)
- R5F
- ROTIGOTINE [MI]
- N04BC09
- J-502471
- (S)-5,6,7,8-tetrahydro-6-[propyl[2-(2-thienyl)ethyl]amino]-1-naphthol
- NCGC00168748-02
- DB05271
- DTXCID3026772
- ROTIGOTINE [USP-RS]
- F13103
- ROTIGOTINE (EP MONOGRAPH)
- A846076
- (S)-6-[Propyl-(2-thiophen-2-yl-ethyl)-amino]-5,6,7,8-tetrahydro-naphthalen-1-ol
- N-0923
- Rotigotine?
- BRD-K91111634-001-01-2
- HY-75502R
- Rotigotine (Standard)
- FT76640
-
- MDL： MFCD00870193
- Inchi： 1S/C19H25NOS/c1-2-11-20(12-10-17-6-4-13-22-17)16-8-9-18-15(14-16)5-3-7-19(18)21/h3-7,13,16,21H,2,8-12,14H2,1H3/t16-/m0/s1
- InChI Key： KFQYTPMOWPVWEJ-INIZCTEOSA-N
- SMILES： S1C=CC=C1CCN(CCC)[C@@H]1CC2C=CC=C(C=2CC1)O
Computed Properties
- Exact Mass: 315.165685
- Monoisotopic Mass: 315.165685
- Isotope Atom Count: 0
- Hydrogen Bond Donor Count: 1
- Hydrogen Bond Acceptor Count: 3
- Heavy Atom Count: 22
- Rotatable Bond Count: 6
- Complexity: 337
- Covalently-Bonded Unit Count: 1
- Defined Atom Stereocenter Count: 1
- Undefined Atom Stereocenter Count : 0
- Defined Bond Stereocenter Count: 0
- Undefined Bond Stereocenter Count: 0
- Topological Polar Surface Area: 51.7
- XLogP3: 4.9
Experimental Properties
- Color/Form: No data available
- Density: 1.15
- Melting Point: 78°C(lit.)
- Boiling Point: 470.1±45.0 °C at 760 mmHg
- Flash Point: 238.1±28.7 °C
- Refractive Index: 1.611
- PSA: 51.71000
- LogP: 4.26570
Rotigotine Security Information
-
Symbol:
- Signal Word：Warning
- Hazard Statement： H302
- Warning Statement： P264+P280+P305+P351+P338+P337+P313
- WGK Germany：2
- Hazard Category Code： 22
- Safety Instruction： H302
- RTECS：QK4252968
-
Hazardous Material Identification：
- Storage Condition：Powder -20°C 3 years ? 4°C 2 years In solvent -80°C 6 months ? -20°C 1 month
Rotigotine Pricemore >>
| Related Categories | No. | Product Name | Cas No. | Purity | Specification | Price | update time | Inquiry |
|---|---|---|---|---|---|---|---|---|
| SHANG HAI YI EN HUA XUE JI SHU Co., Ltd. | R027296-10mg |
Rotigotine |
99755-59-6 | 98% | 10mg |
￥614 | 2024-07-19 | |
| SHANG HAI YI EN HUA XUE JI SHU Co., Ltd. | R027296-50mg |
Rotigotine |
99755-59-6 | 98% | 50mg |
￥2052 | 2024-07-19 | |
| SHANG HAI TAO SHU Biotechnology Co., Ltd. | T6647-5 mg |
Rotigotine |
99755-59-6 | 99.59% | 5mg |
￥410.00 | 2021-09-23 | |
| SHANG HAI TAO SHU Biotechnology Co., Ltd. | T6647-10 mg |
Rotigotine |
99755-59-6 | 99.59% | 10mg |
￥647.00 | 2021-09-23 | |
| SHANG HAI TAO SHU Biotechnology Co., Ltd. | T6647-25 mg |
Rotigotine |
99755-59-6 | 99.59% | 25mg |
￥1353.00 | 2021-09-23 | |
| SHANG HAI TAO SHU Biotechnology Co., Ltd. | T6647-50 mg |
Rotigotine |
99755-59-6 | 99.59% | 50mg |
￥2443.00 | 2021-09-23 | |
| SHANG HAI TAO SHU Biotechnology Co., Ltd. | T6647-100 mg |
Rotigotine |
99755-59-6 | 99.59% | 100MG |
￥3772.00 | 2021-09-23 | |
| SHANG HAI TAO SHU Biotechnology Co., Ltd. | T6647-200 mg |
Rotigotine |
99755-59-6 | 99.59% | 200mg |
￥6642.00 | 2021-09-23 | |
| SHANG HAI TAO SHU Biotechnology Co., Ltd. | T6647-1 mL * 10 mM (in DMSO) |
Rotigotine |
99755-59-6 | 99.59% | 1 mL * 10 mM (in DMSO) |
￥410.00 | 2021-09-23 | |
| WU HAN AN JIE KAI Biomedical Technology Co., Ltd. | ajci5470-10mg |
Rotigotine |
99755-59-6 | 98% | 10mg |
￥617.00 | 2023-09-10 |
Rotigotine Suppliers
Suzhou Senfeida Chemical Co., Ltd
Gold Member
Audited Supplier
(CAS:99755-59-6)ROTIGOTINE
Order Number:sfd17611
Stock Status:in Stock
Quantity:200kg
Purity:99.9%
Pricing Information Last Updated:Friday, 19 July 2024 14:37
Price ($):discuss personally
Email:[email protected]
Amadis Chemical Company Limited
Gold Member
Audited Supplier
(CAS:99755-59-6)Rotigotine
Order Number:A846076
Stock Status:in Stock
Quantity:250mg/1g/25mg/50mg/100mg/200mg/500mg
Purity:99%
Pricing Information Last Updated:Friday, 30 August 2024 07:08
Price ($):2515.0/6286.0/158.0/291.0/411.0/588.0/905.0
Email:[email protected]
Tiancheng Chemical (Jiangsu) Co., Ltd
Gold Member
Audited Supplier
(CAS:99755-59-6)羅替戈汀
Order Number:LE25955617
Stock Status:in Stock
Quantity:25KG,200KG,1000KG
Purity:99%
Pricing Information Last Updated:Friday, 20 June 2025 12:54
Price ($):discuss personally
Email:[email protected]
Rotigotine Related Literature
-
Xiaoming Liu,Zachary D. Hood,Wangda Li,Donovan N. Leonard,Arumugam Manthiram,Miaofang Chi J. Mater. Chem. A, 2021,9, 2111-2119
-
Olga Guselnikova,Gérard Audran,Jean-Patrick Joly,Andrii Trelin,Evgeny V. Tretyakov,Vaclav Svorcik,Oleksiy Lyutakov,Sylvain R. A. Marque Chem. Sci., 2021,12, 4154-4161
-
Domenico Lombardo,Gianmarco Munaò,Pietro Calandra,Luigi Pasqua,Maria Teresa Caccamo Phys. Chem. Chem. Phys., 2019,21, 11983-11991
-
Hanie Hashtroudi,Ian D. R. Mackinnon J. Mater. Chem. C, 2020,8, 13108-13126
-
Guiying Zhang,Maosheng Cheng,Yanni Li,Keliang Liu,Lifeng Cai Chem. Commun., 2013,49, 11086-11088
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Recommended suppliers
Suzhou Senfeida Chemical Co., Ltd
(CAS:99755-59-6)ROTIGOTINE
Purity:99.9%
Quantity:200kg
Price ($):Inquiry
Amadis Chemical Company Limited
(CAS:99755-59-6)Rotigotine
Purity:99%/99%/99%/99%/99%/99%/99%
Quantity:250mg/1g/25mg/50mg/100mg/200mg/500mg
Price ($):2515.0/6286.0/158.0/291.0/411.0/588.0/905.0