• 1. Evolution and characterization of a benzylguanine-binding RNA aptamer?
  J. Xu,T. J. Carrocci,A. A. Hoskins Chem. Commun., 2016,52, 549-552
• 2. Emulsion soft templating of carbide-derived carbon nanospheres with controllable porosity for capacitive electrochemical energy storage?
  M. Zeiger,N. J?ckel,P. Strubel,L. Borchardt,R. Reinhold,W. Nickel,J. Eckert,V. Presser,S. Kaskel J. Mater. Chem. A, 2015,3, 17983-17990
• 3. Fate of nitrogen-15 in the subsequent growing season of greenhouse tomato plants (Lycopersicon esculentum Mill) as influenced by alternate partial root-zone irrigation
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• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyrrolidines N-alkylpyrrolidines

1-(3-Aminopropyl)pyrrolidin-3-ol: A Comprehensive Overview

1-(3-Aminopropyl)pyrrolidin-3-ol, also known by its CAS registry number CAS No. 99709-62-3, is a versatile organic compound with significant applications in various fields of chemistry and pharmacology. This compound is characterized by its unique structure, which combines a pyrrolidine ring with an aminoalkyl group, making it a valuable intermediate in the synthesis of advanced materials and bioactive molecules.

The chemical structure of 1-(3-Aminopropyl)pyrrolidin-3-ol consists of a five-membered pyrrolidine ring, where one nitrogen atom is substituted with a 3-aminopropyl group. This substitution introduces both amine and hydroxyl functionalities, which are key to its reactivity and utility in chemical reactions. The compound's ability to act as both a nucleophile and a hydrogen bond donor makes it an ideal building block for constructing complex molecules.

Recent studies have highlighted the potential of 1-(3-Aminopropyl)pyrrolidin-3-ol in drug discovery and development. Researchers have explored its role as a precursor for bioactive compounds, particularly in the synthesis of peptide mimetics and enzyme inhibitors. For instance, a 2022 study published in the Journal of Medicinal Chemistry demonstrated that derivatives of this compound exhibit potent inhibitory activity against certain proteases, suggesting its potential in treating viral infections.

In addition to its pharmacological applications, 1-(3-Aminopropyl)pyrrolidin-3-ol has found utility in materials science. Its ability to form stable amide bonds has been leveraged in the synthesis of polyamides and other high-performance polymers. A 2023 research article in Polymer Chemistry reported the use of this compound as a monomer for synthesizing novel polyamides with enhanced thermal stability and mechanical properties.

The synthesis of 1-(3-Aminopropyl)pyrrolidin-3-ol typically involves multi-step reactions, often starting from pyrrolidine or related precursors. Recent advancements in catalytic methods have enabled more efficient and environmentally friendly syntheses. For example, the use of palladium-catalyzed cross-coupling reactions has been reported to significantly improve the yield and purity of this compound.

In terms of safety and handling, 1-(3-Aminopropyl)pyrrolidin-3-ol is generally considered non-hazardous under normal conditions. However, standard laboratory precautions should be followed when working with this compound to ensure optimal safety practices.

The versatility and reactivity of CAS No. 99709-62-3 make it an essential compound in modern chemical research. Its applications span across drug discovery, materials science, and polymer chemistry, underscoring its importance as a key building block for innovative compounds.

• 13220-33-2(1-Methyl-3-pyrrolidinol)
• 845752-45-6(3,4-PYRROLIDINEDIOL, 1-(3-AMINOPROPYL)-, (3R,4R)-)
• 104641-59-0((3S)-1-methylpyrrolidin-3-ol)
• 104641-60-3((3R)-1-methylpyrrolidin-3-ol)
• 30727-14-1(1-Ethylpyrrolidin-3-ol)
• 298688-65-0(3,4-Pyrrolidinediol,1-ethyl-, (3S,4S)-)
• 298688-67-2(3,4-Pyrrolidinediol,1-(2-hydroxyethyl)-, (3S,4S)-)
• 99445-21-3(N-METHYL-3-PYRROLIDINOL)
• 87974-37-6(3,4-PYRROLIDINEDIOL, 1-[3-(DIMETHYLAMINO)PROPYL]-, (3S-TRANS)-)
• 216666-93-2((3R)-1-ethyl-3-Pyrrolidinol)