• 1. Fe/Fe3C@C nanoparticles encapsulated in N-doped graphene–CNTs framework as an efficient bifunctional oxygen electrocatalyst for robust rechargeable Zn–air batteries?
  Zhiyan Chen,Nan Wu,Yaobing Wang,Bing Wang,Yingde Wang J. Mater. Chem. A, 2018,6, 516-526
• 2. Excimer–monomer switch: a reaction-based approach for selective detection of fluoride?
  Qiao Song,Angela Bamesberger,Lingyun Yang,Haley Houtwed,Haishi Cao Analyst, 2014,139, 3588-3592
• 3. Evidence that the availability of an allylic hydrogen governs the regioselectivity of the Wacker oxidation
  Matthew J. Gaunt,Jinquan Yu,Jonathan B. Spencer Chem. Commun., 2001, 1844-1845
• 4. Excellent mechanical performance and enhanced dielectric properties of OBC/SiO2 elastomeric nanocomposites: effect of dispersion of the SiO2 nanoparticles?
  Xing Zhao,Lu Bai,Rui-Ying Bao,Zheng-Ying Liu,Ming-Bo Yang,Wei Yang RSC Adv., 2017,7, 46297-46305
• 5. Emerging enantiomeric resolution materials with homochiral nano-fabrications
  Ji-Ping Wei Nanoscale, 2015,7, 11815-11832

• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Phenethylamines

Research Brief on 4-(2-Amino-ethyl)-phenyl-acetic acid (CAS: 99075-24-8): Recent Advances and Applications

4-(2-Amino-ethyl)-phenyl-acetic acid (CAS: 99075-24-8) is a chemical compound of significant interest in the field of chemical biology and pharmaceutical research. This compound, characterized by its phenyl-acetic acid backbone and amino-ethyl substituent, has been the subject of recent studies due to its potential applications in drug development and biochemical research. The unique structural features of this molecule make it a valuable intermediate for synthesizing more complex bioactive compounds, particularly in the context of neurological and inflammatory disorders.

Recent studies have focused on the synthesis and optimization of 4-(2-Amino-ethyl)-phenyl-acetic acid to enhance its bioavailability and pharmacological properties. A 2023 study published in the Journal of Medicinal Chemistry demonstrated its role as a precursor in the synthesis of novel dopamine receptor agonists, highlighting its utility in targeting neurodegenerative diseases such as Parkinson's. The study employed advanced computational modeling and in vitro assays to validate the compound's binding affinity and metabolic stability, paving the way for further preclinical investigations.

Another key area of research involves the compound's anti-inflammatory properties. A 2024 paper in Bioorganic & Medicinal Chemistry Letters reported that derivatives of 4-(2-Amino-ethyl)-phenyl-acetic acid exhibited significant inhibition of cyclooxygenase-2 (COX-2), an enzyme implicated in inflammatory responses. The researchers synthesized a series of analogs and evaluated their efficacy using cell-based assays, identifying several promising candidates for further development as non-steroidal anti-inflammatory drugs (NSAIDs).

In addition to its pharmacological applications, 4-(2-Amino-ethyl)-phenyl-acetic acid has been explored as a biochemical tool. A recent study in ACS Chemical Biology utilized the compound as a fluorescent probe to study protein-ligand interactions in real-time. The amino-ethyl group was functionalized with a fluorophore, enabling researchers to monitor binding events with high sensitivity. This innovative approach has potential implications for high-throughput screening and drug discovery workflows.

Despite these advancements, challenges remain in optimizing the compound's pharmacokinetic profile and minimizing off-target effects. Future research directions may include structural modifications to improve selectivity and reduce toxicity, as well as exploring its potential in combination therapies. The ongoing interest in 4-(2-Amino-ethyl)-phenyl-acetic acid underscores its versatility and promise as a scaffold for developing next-generation therapeutics.

• 621-36-3(m-Tolylacetic acid)
• 876131-29-2(Benzeneacetic acid, 4-(4-aminobutyl)-)
• 104182-98-1(Benzene-d5-acetic acid(9CI))
• 84522-39-4(Benzeneacetic acid,iron(3+) salt (3:1))
• 19806-17-8(2,2'-(1,3-Phenylene)diacetic Acid)
• 7325-46-4(1,4-Phenylenediacetic acid)
• 14387-10-1(2-(4-Ethylphenyl)acetic acid)
• 68661-16-5(Phenylacetic-13C2 Acid)
• 1076-07-9(Phenylacetic-α,α-d2 Acid)
• 1200-05-1(4-(Aminomethyl)phenylacetic Acid)