• 1. Organocatalytic Michael addition–lactonisation of carboxylic acids using α,β-unsaturated trichloromethyl ketones as α,β-unsaturated ester equivalents
  Louis C. Morrill,Daniel G. Stark,James E. Taylor,Siobhan R. Smith,James A. Squires,Agathe C. A. D'Hollander,Carmen Simal,Peter Shapland,Timothy J. C. O'Riordan,Andrew D. Smith Org. Biomol. Chem. 2014 12 9016
• 2. 50. Syntheses in the phenanthrene series. Part IV. 1-Methoxy-2-methylphenanthrene and the preparation of substituted phenylacetic acids
  Peter Hill,W. F. Short J. Chem. Soc. 1937 260
• 3. Exploring the scope of the isothiourea-mediated synthesis of dihydropyridinones
  Pei-Pei Yeh,David S. B. Daniels,Charlene Fallan,Eoin Gould,Carmen Simal,James E. Taylor,Alexandra M. Z. Slawin,Andrew D. Smith Org. Biomol. Chem. 2015 13 2177
• 4. Anomalous Schmidt reaction products of phenylacetic acid and derivatives
  Carolyn C. Woodroofe,Boyu Zhong,Xingliang Lu,Richard B. Silverman J. Chem. Soc. Perkin Trans. 2 2000 55
• 5. FeCl3-catalyzed oxidative decarboxylation of aryl/heteroaryl acetic acids: preparation of selected API impurities
  Chinnakuzhanthai Gangadurai,Giri Teja Illa,D. Srinivasa Reddy Org. Biomol. Chem. 2020 18 8459

• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Toluenes
• Solvents and Organic Chemicals Organic Compounds Acids/Esters

Comprehensive Overview of m-Tolylacetic acid (CAS No. 621-36-3): Properties, Applications, and Market Insights

m-Tolylacetic acid (CAS No. 621-36-3), also known as 3-methylphenylacetic acid, is an organic compound belonging to the class of aromatic carboxylic acids. This white crystalline solid is widely utilized in pharmaceutical intermediates, fragrance synthesis, and specialty chemical applications. With the increasing demand for fine chemicals in the pharmaceutical industry and flavor & fragrance sector, m-Tolylacetic acid has gained significant attention from researchers and manufacturers alike.

The molecular structure of m-Tolylacetic acid features a methyl group at the meta position of the phenyl ring, which influences its chemical reactivity and physical properties. This structural characteristic makes it particularly valuable for creating derivatives used in drug development and perfume formulations. Recent studies in green chemistry have explored more sustainable production methods for this compound, aligning with the global trend toward environmentally friendly manufacturing processes.

In pharmaceutical applications, m-Tolylacetic acid serves as a key building block for non-steroidal anti-inflammatory drugs (NSAIDs) and other therapeutic agents. The compound's versatility stems from its ability to undergo various chemical transformations, including esterification, amidation, and halogenation. These properties make it particularly valuable in medicinal chemistry, where researchers are constantly seeking novel drug candidates to address emerging health challenges.

The fragrance industry extensively uses m-Tolylacetic acid and its derivatives as synthetic aroma chemicals. When properly formulated, these compounds contribute to floral and honey-like notes in perfumes and cosmetic products. With consumers increasingly demanding long-lasting fragrances and unique scent profiles, the market for specialized aromatic chemicals like m-Tolylacetic acid continues to expand.

From a commercial perspective, the global market for m-Tolylacetic acid has shown steady growth, particularly in regions with strong pharmaceutical and cosmetic manufacturing sectors. Asia-Pacific has emerged as both a major producer and consumer, driven by growing healthcare expenditure and personal care product demand. Industry analysts project continued expansion as applications in specialty chemicals and advanced materials continue to develop.

Recent advancements in analytical chemistry have improved the characterization and quality control of m-Tolylacetic acid. Modern techniques such as high-performance liquid chromatography (HPLC) and nuclear magnetic resonance (NMR) spectroscopy enable precise measurement of purity and identification of impurities. These developments are particularly important for pharmaceutical-grade material, where stringent quality standards must be met.

Environmental considerations have become increasingly important in the production and use of m-Tolylacetic acid. Manufacturers are adopting green synthesis methods that reduce waste generation and energy consumption. This shift responds to both regulatory pressures and consumer demand for sustainable chemicals across various industries. Researchers are also investigating the compound's biodegradation pathways to better understand its environmental fate.

Storage and handling of m-Tolylacetic acid require standard precautions for organic acids. The compound should be kept in tightly sealed containers away from strong oxidizers and bases. While not classified as hazardous under normal conditions, proper laboratory safety practices should always be followed when working with this chemical. Material safety data sheets provide detailed guidance for specific handling scenarios.

The future outlook for m-Tolylacetic acid appears promising, with potential applications emerging in advanced material science and biotechnology. Researchers are exploring its use in polymer modification and as a precursor for functional materials. Additionally, its derivatives may find applications in agricultural chemistry as researchers develop new crop protection agents with improved environmental profiles.

For purchasers and researchers seeking high purity m-Tolylacetic acid, it's essential to verify specifications including assay percentage, melting point range, and impurity profiles. Reputable suppliers typically provide comprehensive analytical data and can offer custom synthesis services for specialized applications. The compound is available in various packaging options ranging from laboratory-scale quantities to bulk industrial amounts.

In conclusion, m-Tolylacetic acid (CAS No. 621-36-3) represents an important intermediate in modern chemical industries. Its diverse applications spanning pharmaceuticals, fragrances, and specialty chemicals ensure continued relevance in various sectors. As research progresses and new applications emerge, this versatile compound will likely maintain its position as a valuable building block in organic synthesis and industrial chemistry.

• 17283-16-8(2-(3,4-Dimethylphenyl)acetic acid)
• 104182-98-1(Benzene-d5-acetic acid(9CI))
• 19806-17-8(2,2'-(1,3-Phenylene)diacetic Acid)
• 7325-46-4(1,4-Phenylenediacetic acid)
• 42288-46-0(3,5-Dimethylphenylacetic acid)
• 622-47-9(2-(p-tolyl)acetic acid)
• 14387-10-1(2-(4-Ethylphenyl)acetic acid)
• 4435-67-0(H3BTA)
• 114-70-5(Sodium 2-phenylacetate)
• 1076-07-9(Phenylacetic-α,α-d2 Acid)