Exploring the scope of the isothiourea-mediated synthesis of dihydropyridinones?
Organic & Biomolecular Chemistry Pub Date: 2015-01-02 DOI: 10.1039/C4OB02408G
Abstract
The exploration and expansion of the scope of the isothiourea-mediated synthesis of dihydropyridinones is presented. The use of ketimines derived from α,β-unsaturated γ-ketoesters as the Michael acceptor in a Michael addition/lactamisation cascade gives access to a range of dihydropyridinones with high enantioselectivity. The nature of the N-sulfonyl group present on the ketimine is extensively investigated, with further studies into derivatisation of the dihydropyridinone core also reported.
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Journal Name：Organic & Biomolecular Chemistry
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CAS no.: 89640-58-4
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