• 1. An investigation on the second-order nonlinear optical response of cationic bipyridine or phenanthroline iridium(iii) complexes bearing cyclometallated 2-phenylpyridines with a triphenylamine substituent?
  David B. Cordes,Alexandra M. Z. Slawin,Stefania Righetto,Denis Jacquemin,Eli Zysman-Colman,Véronique Guerchais Dalton Trans., 2018,47, 8292-8300
• 2. An investigation of surface properties, local elastic modulus and interaction with simulated pulmonary surfactant of surface modified inhalable voriconazole dry powders using atomic force microscopy
  Michael Kappl,Paul M. Young,Daniela Traini,Sanyog Jain RSC Adv., 2016,6, 25789-25798
• 3. Acetyl protected thiol methacrylic polymers as effective ligands to keep quantum dots in luminescent standby mode?
  Marta Liras,Isabel Quijada-Garrido,Marta Palacios-Cuesta,Sonia Mu?oz-Durieux,Olga García Polym. Chem., 2014,5, 433-442
• 4. An integrated digital microfluidic chip for multiplexed proteomic sample preparation and analysis by MALDI-MS?
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• Solvents and Organic Chemicals Organic Compounds Organic oxygen compounds Organooxygen compounds Ketones
• Solvents and Organic Chemicals Organic Compounds Organic oxygen compounds Organooxygen compounds Carbonyl compounds Ketones
• Solvents and Organic Chemicals Organic Compounds Aldehyde/Ketone

Exploring the Versatile Applications and Properties of 1-(2-fluoro-4-hydroxyphenyl)ethan-1-one (CAS No. 98619-07-9)

1-(2-fluoro-4-hydroxyphenyl)ethan-1-one (CAS No. 98619-07-9) is a fluorinated aromatic ketone that has garnered significant attention in pharmaceutical and material science research. This compound, also known as 2'-fluoro-4'-hydroxyacetophenone, features a unique molecular structure combining a hydroxyl group and a fluorine atom on the phenyl ring, making it a valuable intermediate in organic synthesis. Researchers and industry professionals frequently search for "98619-07-9 applications" or "1-(2-fluoro-4-hydroxyphenyl)ethan-1-one synthesis," reflecting its growing importance in specialized chemical processes.

The physicochemical properties of 1-(2-fluoro-4-hydroxyphenyl)ethan-1-one contribute to its versatility. With a molecular weight of 154.14 g/mol, this pale yellow crystalline solid exhibits moderate solubility in organic solvents like ethanol and acetone, while being less soluble in water. Its melting point typically ranges between 85-88°C, and the presence of both fluorine and hydroxyl groups creates interesting electronic effects that influence its reactivity. These characteristics make it particularly useful in designing "fluorinated pharmaceutical intermediates" – a hot topic in drug development circles.

In pharmaceutical applications, 1-(2-fluoro-4-hydroxyphenyl)ethan-1-one serves as a crucial building block for various drug candidates. The "fluoro-hydroxyphenyl" moiety is increasingly important in medicinal chemistry, as evidenced by rising searches for "fluorinated drug scaffolds 2024." This structural motif appears in compounds targeting neurological disorders and metabolic diseases, where the fluorine atom enhances metabolic stability and the hydroxyl group provides a handle for further derivatization. Recent patent literature suggests its utility in developing next-generation kinase inhibitors and GPCR modulators.

The material science sector has discovered innovative uses for 98619-07-9 in advanced polymer systems. As interest grows in "high-performance fluorinated polymers," this compound's ability to introduce both fluorine and phenolic functionality makes it valuable for creating specialty resins with enhanced thermal stability and chemical resistance. Industry reports indicate its experimental use in photoresist formulations for semiconductor manufacturing – a field experiencing rapid growth due to demands in "AI chip fabrication materials."

Synthetic approaches to 1-(2-fluoro-4-hydroxyphenyl)ethan-1-one typically involve Friedel-Crafts acylation of fluorophenol derivatives or selective fluorination of hydroxyphenyl ketones. Modern "green chemistry" trends have spurred development of catalytic methods that reduce waste, aligning with searches for "sustainable fluorination methods." Recent publications highlight microwave-assisted and continuous flow syntheses that improve yield and purity while minimizing environmental impact – key considerations for manufacturers facing tightening regulations.

Analytical characterization of 1-(2-fluoro-4-hydroxyphenyl)ethan-1-one employs standard techniques including HPLC, GC-MS, and NMR spectroscopy. The 19F NMR signal typically appears around -110 ppm, providing a distinct fingerprint for quality control. Purity standards have become more stringent, driven by pharmaceutical industry demands for "high-purity fluorinated intermediates" – a search term showing increased activity in chemical databases. Advanced users often look for "98619-07-9 spectroscopic data" when verifying compound identity.

Market dynamics for 2'-fluoro-4'-hydroxyacetophenone reflect broader trends in fine chemicals. While comprehensive production data remains proprietary, industry analysts note growing demand from Asian pharmaceutical manufacturers, particularly in India and China. The global market for "fluorinated building blocks" is projected to expand at 6-8% annually through 2026, with compounds like 98619-07-9 benefiting from this trend. Current pricing intelligence suggests moderate costs for research quantities, with bulk pricing available for commercial-scale purchasers.

Handling and storage recommendations for 1-(2-fluoro-4-hydroxyphenyl)ethan-1-one follow standard laboratory practices for aromatic ketones. The material should be kept in tightly sealed containers under inert atmosphere at room temperature, protected from light. While not classified as hazardous under standard regulations, proper PPE including gloves and eye protection is recommended when handling – a prudent approach that aligns with modern "laboratory safety best practices" frequently searched by chemical professionals.

Future research directions for 98619-07-9 may explore its potential in emerging fields like "metal-organic frameworks" (MOFs) or "covalent organic polymers" (COPs), where its bifunctional nature could enable novel material designs. The compound's utility in "PET tracer development" represents another promising avenue, given the fluorine-18 isotope's importance in medical imaging. These applications correspond to trending searches in "advanced fluorinated materials" and "molecular imaging probes," indicating where scientific interest is heading.

For researchers seeking 1-(2-fluoro-4-hydroxyphenyl)ethan-1-one, multiple specialty chemical suppliers offer the compound in various purities. Technical specifications typically include ≥97% purity by HPLC, with some vendors providing analytical certificates meeting "pharmaceutical grade standards." Custom synthesis options are available for users requiring specific isotopic labeling or derivative forms – services increasingly important for drug discovery teams working on "next-generation therapeutics."

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• 1208078-35-6(1-(2-Fluoro-4-hydroxyphenyl)-2-methylpropan-1-one)
• 101969-75-9(2-Fluoro-4'-hydroxybenzophenone)
• 8039-09-6(1-(2-Fluoro-5-methoxyphenyl)ethanone)
• 1378820-19-9(1-(2,6-Difluoro-4-hydroxyphenyl)ethanone)
• 74457-86-6(1-(2-fluoro-4-methoxyphenyl)ethan-1-one)
• 886498-84-6(1-(2,6-difluoro-4-methoxyphenyl)ethan-1-one)
• 145300-04-5(1-(2-fluoro-5-hydroxyphenyl)ethan-1-one)