• 1. An amide probe as a selective Al3+ and Fe3+ sensor inside the HeLa and a549 cell lines: Pictet–Spengler reaction for the rapid detection of tryptophan amino acid?
  Bidyut Kumar Kundu,Rinky Singh,Ritudhwaj Tiwari,Debasis Nayak New J. Chem., 2019,43, 4867-4877
• 2. An approach to 7-aza-1-phosphanorbornane complexes: strain promoted rearrangement of 1-iminylphosphirane complexes and cycloaddition with olefins?
  Yang Xu,Min Wang,Donghui Wei,Rongqiang Tian,Zheng Duan,Fran?ois Mathey Dalton Trans., 2019,48, 5523-5526
• 3. An atlas of endohedral Sc2S cluster fullerenes?
  Li-Hua Gan,Rui Wu,Jian-Lei Tian,Patrick W. Fowler Phys. Chem. Chem. Phys., 2017,19, 419-425
• 4. An analysis of the WTC fires using CIB correlations and simple modeling
  JGQuintiere
• 5. An algal process treatment combined with the Fenton reaction for high concentrations of amoxicillin and cefradine
  Haitao Li,Yu Pan,Zhizhi Wang,Shan Chen,Ruixin Guo,Jianqiu Chen RSC Adv., 2015,5, 100775-100782

• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Sulfanilides

N-(2-Fluorophenyl)Methanesulfonamide: An Overview of a Versatile Compound (CAS No. 98611-90-6)

N-(2-Fluorophenyl)methanesulfonamide, also known as 2-fluorobenzyl sulfonamide, is a compound with the CAS number 98611-90-6. This molecule has garnered significant attention in the fields of medicinal chemistry and pharmaceutical research due to its unique properties and potential applications. The compound is characterized by a methanesulfonamide group attached to a 2-fluorophenyl ring, which imparts specific chemical and biological activities.

The chemical structure of N-(2-Fluorophenyl)methanesulfonamide consists of a benzene ring with a fluorine atom at the 2-position and a methanesulfonamide group attached to the benzene ring. The presence of the fluorine atom and the sulfonamide group provides this compound with distinct electronic and steric properties, making it an attractive candidate for various chemical and biological studies.

Recent research has highlighted the potential of N-(2-Fluorophenyl)methanesulfonamide in several areas, including its use as an intermediate in the synthesis of more complex molecules, its role in drug discovery, and its biological activities. One notable application is its use as a building block in the development of new pharmaceuticals. The sulfonamide moiety is known for its ability to form hydrogen bonds and interact with biological targets, which can enhance the binding affinity and selectivity of drug candidates.

In the context of medicinal chemistry, N-(2-Fluorophenyl)methanesulfonamide has been explored for its potential as an inhibitor of various enzymes and receptors. For instance, studies have shown that derivatives of this compound can act as potent inhibitors of carbonic anhydrase, an enzyme involved in various physiological processes such as pH regulation and ion transport. The ability to modulate carbonic anhydrase activity has implications for treating conditions like glaucoma and epilepsy.

Moreover, N-(2-Fluorophenyl)methanesulfonamide has been investigated for its anti-inflammatory properties. Inflammation is a key factor in many diseases, including arthritis and inflammatory bowel disease. Research has demonstrated that certain derivatives of this compound can inhibit pro-inflammatory cytokines and reduce inflammation in animal models. This suggests that N-(2-Fluorophenyl)methanesulfonamide could serve as a lead compound for developing new anti-inflammatory drugs.

Another area where N-(2-Fluorophenyl)methanesulfonamide shows promise is in cancer research. Some studies have reported that this compound can induce apoptosis (programmed cell death) in cancer cells by disrupting specific signaling pathways. This property makes it a potential candidate for developing new anticancer agents. Additionally, the fluorine atom in the molecule can enhance its metabolic stability and improve its pharmacokinetic profile, which are crucial factors for effective drug delivery.

The synthesis of N-(2-Fluorophenyl)methanesulfonamide typically involves reacting 2-fluorobenzylamine with methanesulfonyl chloride in the presence of a base such as triethylamine. This reaction yields high purity product with good yield, making it suitable for large-scale production. The synthetic route is well-documented in the literature and can be adapted to produce various derivatives by modifying the starting materials or reaction conditions.

In terms of safety and handling, N-(2-Fluorophenyl)methanesulfonamide should be handled with care due to its reactivity and potential health effects. Proper personal protective equipment (PPE) should be used when handling this compound, and it should be stored in a well-ventilated area away from incompatible materials. Safety data sheets (SDS) provide detailed information on handling, storage, and disposal procedures.

Overall, N-(2-Fluorophenyl)methanesulfonamide (CAS No. 98611-90-6) is a versatile compound with significant potential in medicinal chemistry and pharmaceutical research. Its unique chemical structure and biological activities make it an attractive candidate for developing new drugs targeting various diseases. Ongoing research continues to uncover new applications and optimize its properties for therapeutic use.

• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)
• 1270529-38-8(1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol)
• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)
• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)
• 1444113-98-7(N-(3-cyanothiolan-3-yl)-2-[(2,2,2-trifluoroethyl)sulfanyl]pyridine-4-carboxamide)
• 941977-17-9(N'-(3-chloro-2-methylphenyl)-N-2-(dimethylamino)-2-(naphthalen-1-yl)ethylethanediamide)
• 2138166-62-6(2,2-Difluoro-3-[methyl(2-methylbutyl)amino]propanoic acid)
• 89640-58-4(2-Iodo-4-nitrophenylhydrazine)
• 1449132-38-0(3-Fluoro-5-(2-fluoro-5-methylbenzylcarbamoyl)benzeneboronic acid)
• 2034271-14-0(2-(1H-indol-3-yl)-N-{[6-(thiophen-2-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]methyl}acetamide)