Cas no 98599-84-9 (4'-Demethyl Homoharringtonine)
4'-Demethyl Homoharringtonine is a bioactive alkaloid derived from cephalotaxus species, structurally related to homoharringtonine. It exhibits potent antineoplastic activity, particularly in inhibiting protein synthesis by targeting the ribosomal A-site. This compound is of interest in oncology research due to its potential efficacy against hematologic malignancies and solid tumors, with studies emphasizing its mechanism of action and therapeutic applications.
4'-Demethyl Homoharringtonine structure
Product Name:4'-Demethyl Homoharringtonine
CAS No:98599-84-9
MF:C28H37NO9
MW:531.594689130783
CID:801961
PubChem ID:26499229
Update Time:2025-06-20
4'-Demethyl Homoharringtonine Chemical and Physical Properties
Names and Identifiers
-
- Cephalotaxine,4-hydrogen (2R)-2-hydroxy-2-(4-hydroxy-4-methylpentyl)butanedioate (ester)(9CI)
- 4′-Demethyl Homoharringtonine
- 4?-Demethyl Homoharringtonine
- 4'-DeMethyl HoMoharringtonine
- 5'-Des-O-methylhomoharringtonine
- 98599-84-9
- Homoharringtonine acid
- (3R)-3,7-Dihydroxy-3-[[(2S,3S,6R)-4-methoxy-16,18-dioxa-10-azoniapentacyclo[11.7.0.02,6.06,10.015,19]icosa-1(20),4,13,15(19)-tetraen-3-yl]oxycarbonyl]-7-methyloctanoate
- O~3~-[(2R)-2-(Carboxymethyl)-2,6-dihydroxy-6-methylheptanoyl]cephalotaxine
- DTXSID90650139
- SCHEMBL15827510
- (3R)-3,7-dihydroxy-3-[[(2S,3S,6R)-4-methoxy-16,18-dioxa-10-azapentacyclo[11.7.0.02,6.06,10.015,19]icosa-1(20),4,13,15(19)-tetraen-3-yl]oxycarbonyl]-7-methyloctanoic acid
- LRNKGNYRSLLFRU-KSZYUSJVSA-N
- 4'-Demethyl Homoharringtonine
-
- Inchi： 1S/C28H37NO9/c1-26(2,33)7-4-9-28(34,15-22(30)31)25(32)38-24-21(35-3)14-27-8-5-10-29(27)11-6-17-12-19-20(37-16-36-19)13-18(17)23(24)27/h12-14,23-24,33-34H,4-11,15-16H2,1-3H3,(H,30,31)/t23-,24-,27+,28-/m1/s1
- InChI Key： LRNKGNYRSLLFRU-KSZYUSJVSA-N
- SMILES： O(C([C@](CC(=O)O)(CCCC(C)(C)O)O)=O)[C@@H]1C(=C[C@]23CCCN2CCC2C=C4C(=CC=2[C@@H]31)OCO4)OC
Computed Properties
- Exact Mass: 531.24700
- Monoisotopic Mass: 531.24683176g/mol
- Isotope Atom Count: 0
- Hydrogen Bond Donor Count: 3
- Hydrogen Bond Acceptor Count: 10
- Heavy Atom Count: 38
- Rotatable Bond Count: 10
- Complexity: 953
- Covalently-Bonded Unit Count: 1
- Defined Atom Stereocenter Count: 4
- Undefined Atom Stereocenter Count : 0
- Defined Bond Stereocenter Count: 0
- Undefined Bond Stereocenter Count: 0
- XLogP3: -1.8
- Topological Polar Surface Area: 135?2
Experimental Properties
- PSA: 134.99000
- LogP: 2.43020
4'-Demethyl Homoharringtonine Pricemore >>
| Related Categories | No. | Product Name | Cas No. | Purity | Specification | Price | update time | Inquiry |
|---|---|---|---|---|---|---|---|---|
| TRC | D231150-25mg |
4'-Demethyl Homoharringtonine |
98599-84-9 | 25mg |
$ 800.00 | 2023-09-08 | ||
| TRC | D231150-2.5mg |
4'-Demethyl Homoharringtonine |
98599-84-9 | 2.5mg |
$523.00 | 2023-05-18 | ||
| TRC | D231150-10mg |
4'-Demethyl Homoharringtonine |
98599-84-9 | 10mg |
$1671.00 | 2023-05-18 |
4'-Demethyl Homoharringtonine Related Literature
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Adeline Huiling Loo,Alessandra Bonanni,Martin Pumera Analyst, 2013,138, 467-471
-
Yaqing Liu,Jiangtao Ren,Jing Li,Jiyang Liu,Erkang Wang Chem. Commun., 2012,48, 802-804
-
Christian K. Rank,Alexander W. Jones,Tatjana Wall,Patrick Di Martino-Fumo,Sarah Schr?ck,Markus Gerhards,Frederic W. Patureau Chem. Commun., 2019,55, 13749-13752
-
Patricia A. A. M. Vaz,Jo?o Rocha,Artur M. S. Silva New J. Chem., 2016,40, 8198-8201
-
Inês S. Albuquerque,Hélia F. Jeremias,Miguel Chaves-Ferreira,Dijana Matak-Vinkovic,Omar Boutureira,Carlos C. Rom?o Chem. Commun., 2015,51, 3993-3996
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