• 1. Acetylcholinesterase amperometric detection system based on a cobalt(II) tetraphenylporphyrin-modified electrode
  Analyst, 1996,121, 1123-1126
• 2. An integrated process of CO2 capture and in situ hydrogenation to formate using a tunable ethoxyl-functionalized amidine and Rh/bisphosphine system?
  Yu-Nong Li,Liang-Nian He,Xian-Dong Lang,Xiao-Fang Liu,Shuai Zhang RSC Adv., 2014,4, 49995-50002
• 3. Aggregated-fluorescent detection of PFAS with a simple chip
  Cheng Fang,Jinjian Wu,Zahra Sobhani,Md. Al Amin,Youhong Tang Anal. Methods, 2019,11, 163-170
• 4. An antimonate pyrochlore (H1.23Sr0.45SbO3.48) for photocatalytic oxidation of benzene: effective oxygen usage and excellent activity?
  Jing Chen,Yu Shao,Danzhen Li J. Mater. Chem. A, 2017,5, 937-941
• 5. An integrated chip for immunofluorescence and its application to analyze lysosomal storage disorders
  Jie Shen,Ying Zhou,Tu Lu,Junya Peng,Zhixiang Lin,Yuhong Pang,Li Yu Lab Chip, 2012,12, 317-324

Introduction to 5-Bromopyridine-2,3-dicarboxylic acid (CAS No. 98555-51-2)

5-Bromopyridine-2,3-dicarboxylic acid, identified by its Chemical Abstracts Service (CAS) number 98555-51-2, is a specialized organic compound that has garnered significant attention in the field of pharmaceutical and chemical research. This heterocyclic compound features a pyridine core substituted with two carboxylic acid groups and a bromine atom, making it a versatile intermediate in the synthesis of various bioactive molecules.

The structure of 5-Bromopyridine-2,3-dicarboxylic acid consists of a six-membered aromatic ring containing nitrogen, which is a key feature for its reactivity and biological activity. The presence of two carboxylic acid functionalities at the 2 and 3 positions enhances its utility as a building block in medicinal chemistry. Additionally, the bromine atom at the 5-position provides a handle for further functionalization via cross-coupling reactions, such as Suzuki-Miyaura or Buchwald-Hartwig couplings, which are widely employed in the construction of complex molecular architectures.

In recent years, 5-Bromopyridine-2,3-dicarboxylic acid has been extensively studied for its potential applications in drug discovery and material science. Its unique structural motifs have made it a valuable scaffold for designing novel therapeutic agents targeting various diseases. For instance, researchers have explored its derivatives as inhibitors of kinases and other enzymes involved in cancer progression. The pyridine ring serves as a pharmacophore that can interact with biological targets, while the carboxylic acid groups allow for solubility and further derivatization.

One of the most compelling aspects of 5-Bromopyridine-2,3-dicarboxylic acid is its role in the development of metal-organic frameworks (MOFs). MOFs are porous materials composed of metal ions or clusters connected by organic ligands, and they have applications in gas storage, separation, and catalysis. The dicarboxylic acid functionality of this compound makes it an excellent ligand for constructing MOFs with tailored properties. Recent studies have demonstrated the use of 5-Bromopyridine-2,3-dicarboxylic acid to create MOFs with high surface areas and selective binding capabilities for small molecules.

The pharmaceutical industry has also leveraged 5-Bromopyridine-2,3-dicarboxylic acid in the synthesis of antiviral and antibacterial agents. Its structural features allow for the design of molecules that can disrupt viral replication or inhibit bacterial growth. For example, derivatives of this compound have been investigated as potential inhibitors of viral proteases, which are critical enzymes for virus replication. Additionally, its incorporation into drug-like molecules has led to the development of novel antibiotics with improved efficacy against resistant strains.

Another area where 5-Bromopyridine-2,3-dicarboxylic acid has shown promise is in the field of agrochemicals. Researchers have utilized this compound to synthesize new herbicides and pesticides that are more environmentally friendly compared to traditional agrochemicals. The ability to modify its structure allows for the creation of compounds with enhanced selectivity and reduced toxicity to non-target organisms.

The synthesis of 5-Bromopyridine-2,3-dicarboxylic acid typically involves multi-step organic reactions starting from commercially available precursors. One common synthetic route involves the bromination of pyridine followed by carboxylation at the 2 and 3 positions. Advances in synthetic methodologies have improved the efficiency and yield of these reactions, making 5-Bromopyridine-2,3-dicarboxylic acid more accessible for research purposes.

In conclusion,5-Bromopyridine-2,3-dicarboxylic acid (CAS No. 98555-51-2) is a multifunctional compound with broad applications in pharmaceuticals, materials science, and agrochemicals. Its unique structural features make it an invaluable intermediate for synthesizing bioactive molecules and advanced materials. As research continues to uncover new uses for this compound,5-Bromopyridine-2,3-dicarboxylic acid is poised to play an increasingly important role in addressing global challenges in health and sustainability.

• 89-00-9(Quinolinic acid)
• 213771-32-5(methyl 5-bromo-3-methylpyridine-2-carboxylate)
• 886365-43-1(5-Bromo-3-methylpyridine-2-carboxylic acid)
• 138946-42-6(2,3-Pyridinedicarboxylic Acid-d3 (Major))
• 521980-82-5(Dimethyl 5-bromopyridine-2,3-dicarboxylate)
• 339155-13-4(2,3-Pyridinedicarboxylic acid)
• 28605-84-7(Pyridinedicarboxylicacid)
• 87314-99-6(2,3-Pyridinedicarboxylic acid, strontium salt)
• 351003-02-6(5-Bromo-2-methylnicotinic acid)
• 1215916-40-7(methyl 5-bromo-2-methylpyridine-3-carboxylate)