• 1. Examination of the hydrogen-bonding networks in small water clusters (n = 2–5, 13, 17) using absolutely localized molecular orbital energy decomposition analysis?
  Erika A. Cobar,Paul R. Horn,Robert G. Bergman,Martin Head-Gordon Phys. Chem. Chem. Phys., 2012,14, 15328-15339
• 2. Evolution study of photo-synthesized gold nanoparticles by spectral deconvolution model: a quantitative approach
  Chung-Sung Yang,Mong-Shian Shih,Fang-Yi Chang New J. Chem., 2006,30, 729-735
• 3. Emergence of microfluidic wearable technologies
  Joo Chuan Yeo,Kenry Lab Chip, 2016,16, 4082-4090
• 4. Fate of single walled carbon nanotubes in wetland ecosystems?
  Joseph H. Bisesi,Tara Sabo-Attwood Environ. Sci.: Nano, 2014,1, 574-583
• 5. Essential effect of the electrolyte on the mechanical and chemical degradation of LiNi0.8Co0.15Al0.05O2 cathodes upon long-term cycling??
  Xiaoming Liu,Zachary D. Hood,Wangda Li,Donovan N. Leonard,Arumugam Manthiram,Miaofang Chi J. Mater. Chem. A, 2021,9, 2111-2119

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyridines and derivatives Pyridinecarboxylic acids
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyridines and derivatives Pyridinecarboxylic acids and derivatives Pyridinecarboxylic acids

Dimethyl 5-bromopyridine-2,3-dicarboxylate (CAS No. 521980-82-5): A Key Intermediate in Modern Pharmaceutical Synthesis

Dimethyl 5-bromopyridine-2,3-dicarboxylate, identified by its CAS number 521980-82-5, is a versatile and highly valuable intermediate in the realm of pharmaceutical synthesis. This compound, featuring a brominated pyridine core with two esterified carboxyl groups, has garnered significant attention due to its utility in the development of novel therapeutic agents. The unique structural attributes of Dimethyl 5-bromopyridine-2,3-dicarboxylate make it an indispensable building block for chemists and pharmacologists working on complex molecular architectures.

The compound's molecular structure consists of a pyridine ring substituted with a bromine atom at the 5-position and ester groups at the 2 and 3 positions. This configuration provides multiple reactive sites, enabling diverse chemical transformations that are crucial for drug discovery and development. The presence of the bromine atom, in particular, makes it a suitable candidate for cross-coupling reactions such as Suzuki-Miyaura and Buchwald-Hartwig couplings, which are widely employed in constructing biaryl systems found in many active pharmaceutical ingredients (APIs).

In recent years, there has been a surge in research focusing on heterocyclic compounds due to their prevalence in biologically active molecules. Pyridine derivatives, including Dimethyl 5-bromopyridine-2,3-dicarboxylate, have been extensively studied for their potential pharmacological properties. For instance, studies have demonstrated the efficacy of pyridine-based scaffolds in targeting various diseases, including cancer, infectious diseases, and neurological disorders. The ester functionalities in this compound allow for further derivatization, enabling the synthesis of analogs with tailored biological activities.

The pharmaceutical industry has increasingly relied on advanced synthetic methodologies to streamline the production of complex molecules. Dimethyl 5-bromopyridine-2,3-dicarboxylate plays a pivotal role in these processes by serving as a precursor for more intricate structures. Researchers have leveraged its reactivity to develop novel inhibitors and activators of enzymes and receptors. For example, recent studies have highlighted its use in synthesizing small-molecule modulators of protein-protein interactions, which are critical for understanding disease mechanisms and developing targeted therapies.

One notable application of Dimethyl 5-bromopyridine-2,3-dicarboxylate is in the field of antiviral drug development. The pyridine core is a common motif in antiviral agents due to its ability to interact with viral enzymes and proteins. By modifying the substituents on the pyridine ring, chemists can fine-tune the pharmacokinetic and pharmacodynamic properties of potential drug candidates. The ester groups provide additional flexibility for chemical manipulation, allowing for the introduction of various functional moieties that enhance binding affinity and reduce toxicity.

The synthesis of Dimethyl 5-bromopyridine-2,3-dicarboxylate typically involves multi-step organic reactions that require precise control over reaction conditions. Advanced catalytic systems have been developed to improve yields and selectivity, making the process more efficient and sustainable. For instance, palladium-catalyzed cross-coupling reactions have been optimized for the introduction of bromine atoms into pyridine derivatives, ensuring high purity and minimizing byproduct formation.

The growing demand for high-quality intermediates like Dimethyl 5-bromopyridine-2,3-dicarboxylate has led to advancements in manufacturing technologies. Continuous flow chemistry has emerged as a powerful tool for producing complex molecules with greater efficiency and scalability. This approach allows for better control over reaction parameters, reducing waste and improving reproducibility. As a result, pharmaceutical companies are increasingly adopting flow chemistry techniques to synthesize key intermediates such as this one.

In conclusion, Dimethyl 5-bromopyridine-2,3-dicarboxylate (CAS No. 521980-82-5) is a cornerstone intermediate in modern pharmaceutical synthesis. Its unique structural features enable a wide range of chemical transformations that are essential for developing novel therapeutic agents. The ongoing research into pyridine derivatives underscores their significance in addressing global health challenges. As synthetic methodologies continue to evolve, compounds like this will remain at the forefront of drug discovery efforts.

• 98555-51-2(5-Bromopyridine-2,3-dicarboxylic acid)
• 892874-36-1(Diethyl 6-bromoquinoline-2,3-dicarboxylate)
• 213771-32-5(methyl 5-bromo-3-methylpyridine-2-carboxylate)
• 129477-21-0(ethyl 5-bromo-2-methylpyridine-3-carboxylate)
• 886365-43-1(5-Bromo-3-methylpyridine-2-carboxylic acid)
• 605-38-9(2,3-dimethyl pyridine-2,3-dicarboxylate)
• 135338-27-1(dimethyl 6-methylpyridine-2,3-dicarboxylate)
• 24195-07-1(2-(methoxycarbonyl)pyridine-3-carboxylic acid)
• 1215916-40-7(methyl 5-bromo-2-methylpyridine-3-carboxylate)
• 112110-16-4(Dimethyl 5-methylpyridine-2,3-dicarboxylate)