Cas no 98395-62-1 (2-(4-Nitrophenoxy)ethanamine hydrochloride)
2-(4-Nitrophenoxy)ethanamine hydrochloride Chemical and Physical Properties
Names and Identifiers
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- 2-(4-Nitrophenoxy)ethanamine hydrochloride
- 2-(4-nitrophenoxy)Ethanamine HCL
- 4-(2-Aminoethoxy)-1-nitrobenzene, HCl
- Ethanamine,2-(4-nitrophenoxy)-, hydrochloride (1:1)
- AKOS015888972
- AC7478
- DTXSID30656877
- 4-(2-Aminoethoxy)-1-nitrobenzene hydrochloride
- 98395-62-1
- 2-(4-Nitrophenoxy)ethylamine hydrochloride
- A858553
- MFCD09475842
- Ethanamine,2-(4-nitrophenoxy)-,hydrochloride(1:1)
- SCHEMBL3675177
- SY020486
- 2-(4-Nitrophenoxy)ethan-1-amine--hydrogen chloride (1/1)
- 2-(4-nitrophenoxy)ethan-1-amine hydrochloride
- Z2466331835
- 2-(4-nitrophenoxy)ethanamine;hydrochloride
- SB79244
- EN300-73729
- YDA39562
- BS-33432
- 2-(4-Nitrophenoxy)ethanamine, HCl
- 2-(4-nitrophenoxy)ethanaminehydrochloride
- 4-(2-Aminoethoxy)-1-nitrobenzene HCl
-
- MDL： MFCD09475842
- Inchi： 1S/C8H10N2O3.ClH/c9-5-6-13-8-3-1-7(2-4-8)10(11)12;/h1-4H,5-6,9H2;1H
- InChI Key： UIMOMIHYFRGWIG-UHFFFAOYSA-N
- SMILES： Cl.O(CCN)C1C=CC(=CC=1)[N+](=O)[O-]
Computed Properties
- Exact Mass: 218.04600
- Monoisotopic Mass: 218.046
- Isotope Atom Count: 0
- Hydrogen Bond Donor Count: 1
- Hydrogen Bond Acceptor Count: 2
- Heavy Atom Count: 14
- Rotatable Bond Count: 4
- Complexity: 161
- Covalently-Bonded Unit Count: 2
- Defined Atom Stereocenter Count: 0
- Undefined Atom Stereocenter Count : 0
- Defined Bond Stereocenter Count: 0
- Undefined Bond Stereocenter Count: 0
- Surface Charge: 0
- Tautomer Count: nothing
- XLogP3: nothing
- Topological Polar Surface Area: 81.1A^2
Experimental Properties
- Density: 1.7±0.1 g/cm3
- Boiling Point: 371.9°Cat760mmHg
- Flash Point: 178.7°C
- PSA: 81.07000
- LogP: 2.95780
2-(4-Nitrophenoxy)ethanamine hydrochloride Security Information
- Signal Word：warning
- Hazard Statement： Irritant
- Warning Statement： P264+P280+P305+P351+P338+P337+P313
- Safety Instruction： H303+H313+H333
-
Hazardous Material Identification：
- Storage Condition：storage at -4℃ (1-2weeks), longer storage period at -20℃ (1-2years)
2-(4-Nitrophenoxy)ethanamine hydrochloride Customs Data
- HS CODE：2922299090
- Customs Data：
China Customs Code:
2922299090Overview:
2922299090. Other amino groups(naphthol\phenol)And ether\Esters [including their salts, Except those containing more than one oxygen-containing group]. VAT:17.0%. Tax refund rate:13.0%. Regulatory conditions:nothing. MFN tariff:6.5%. general tariff:30.0%
Declaration elements:
Product Name, component content, use to, The color of ethanolamine and its salt should be reported, The package of ethanolamine and its salt shall be declared
Summary:
2922299090. other amino-naphthols and other amino-phenols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%
2-(4-Nitrophenoxy)ethanamine hydrochloride Pricemore >>
| Related Categories | No. | Product Name | Cas No. | Purity | Specification | Price | update time | Inquiry |
|---|---|---|---|---|---|---|---|---|
| Alichem | A019146317-10g |
2-(4-Nitrophenoxy)ethanamine hydrochloride |
98395-62-1 | 95% | 10g |
$158.40 | 2023-08-31 | |
| Apollo Scientific | OR11412-1g |
4-(2-Aminoethoxy)-1-nitrobenzene hydrochloride |
98395-62-1 | 98% | 1g |
￡52.00 | 2025-02-19 | |
| Apollo Scientific | OR11412-5g |
4-(2-Aminoethoxy)-1-nitrobenzene hydrochloride |
98395-62-1 | 98% | 5g |
￡195.00 | 2025-02-19 | |
| SHANG HAI SHAO YUAN SHI JI Co., Ltd. | SY020486-5g |
2-(4-Nitrophenoxy)ethylamine Hydrochloride |
98395-62-1 | ≥95% | 5g |
￥5500.00 | 2025-04-11 | |
| abcr | AB235724-1 g |
4-(2-Aminoethoxy)-1-nitrobenzene hydrochloride, 98%; . |
98395-62-1 | 98% | 1 g |
€110.00 | 2023-07-20 | |
| abcr | AB235724-5 g |
4-(2-Aminoethoxy)-1-nitrobenzene hydrochloride, 98%; . |
98395-62-1 | 98% | 5 g |
€297.00 | 2023-07-20 | |
| abcr | AB235724-10 g |
4-(2-Aminoethoxy)-1-nitrobenzene hydrochloride, 98%; . |
98395-62-1 | 98% | 10g |
€437.00 | 2022-09-28 | |
| TRC | N901420-100mg |
2-(4-Nitrophenoxy)ethanamine Hydrochloride |
98395-62-1 | 100mg |
$ 50.00 | 2022-06-03 | ||
| TRC | N901420-500mg |
2-(4-Nitrophenoxy)ethanamine Hydrochloride |
98395-62-1 | 500mg |
$ 70.00 | 2022-06-03 | ||
| TRC | N901420-1g |
2-(4-Nitrophenoxy)ethanamine Hydrochloride |
98395-62-1 | 1g |
$ 115.00 | 2022-06-03 |
2-(4-Nitrophenoxy)ethanamine hydrochloride Related Literature
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Kay S. McMillan,Anthony G. McCluskey,Annette Sorensen,Marie Boyd,Michele Zagnoni Analyst, 2016,141, 100-110
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Yi Cao,Yujiao Xiahou,Lixiang Xing,Xiang Zhang,Hong Li,ChenShou Wu,Haibing Xia Nanoscale, 2020,12, 20456-20466
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Jason Wan Lab Chip, 2020,20, 4528-4538
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Gaurav J. Shah,Eric P.-Y. Chiou,Ming C. Wu,Chang-Jin “CJ” Kim Lab Chip, 2009,9, 1732-1739
Additional information on 2-(4-Nitrophenoxy)ethanamine hydrochloride
2-(4-Nitrophenoxy)ethanamine Hydrochloride (CAS 98395-62-1): A Comprehensive Technical Profile
2-(4-Nitrophenoxy)ethanamine hydrochloride (CAS 98395-62-1) is an important organic compound with significant applications in pharmaceutical research and specialty chemical synthesis. This amine hydrochloride derivative features a unique molecular structure combining a nitrophenoxy group with an ethanamine moiety, making it valuable for various synthetic pathways.
The compound's molecular formula is C8H11N2O3·HCl, with a molecular weight of 218.64 g/mol. Its structural characteristics include a para-nitrophenoxy group attached to an ethylamine chain, which is protonated as a hydrochloride salt. This configuration provides both solubility advantages and enhanced stability compared to the free base form.
In pharmaceutical applications, 2-(4-nitrophenoxy)ethanamine HCl serves as a versatile building block for drug discovery. Researchers particularly value its nitroaromatic functionality, which can be selectively reduced to amino derivatives or participate in various nucleophilic substitution reactions. Recent studies highlight its potential in developing targeted therapies, especially in the context of enzyme inhibitors and receptor modulators.
The compound's physicochemical properties make it suitable for diverse synthetic applications. It typically appears as a yellow to orange crystalline powder with good solubility in polar solvents like water, methanol, and dimethyl sulfoxide (DMSO). These characteristics facilitate its use in high-throughput screening and combinatorial chemistry approaches that are currently trending in drug discovery programs.
From a synthetic chemistry perspective, CAS 98395-62-1 offers multiple reactive sites for modification. The primary amine group can undergo acylation, sulfonylation, or reductive amination, while the nitro group can be reduced to an amine or participate in cyclization reactions. This versatility explains why it's frequently mentioned in recent patent literature for novel compound development.
Quality control of 2-(4-nitrophenoxy)ethanamine hydrochloride typically involves HPLC analysis, with purity specifications often exceeding 98%. Advanced characterization techniques like LC-MS and NMR spectroscopy confirm its structural integrity. These analytical protocols align with current Good Manufacturing Practice (GMP) standards for pharmaceutical intermediates.
The global market for specialty chemical intermediates like 98395-62-1 has grown significantly, driven by increasing pharmaceutical R&D investments. Industry reports indicate particular demand in bioconjugation chemistry and proteomics research, where its bifunctional nature enables cross-linking applications and molecular probe development.
Storage recommendations for 2-(4-nitrophenoxy)ethanamine HCl include keeping the material in airtight containers at room temperature, protected from light and moisture. These conditions maintain stability for extended periods, an important consideration for research laboratories and chemical suppliers managing inventory.
Recent scientific literature highlights innovative applications of CAS 98395-62-1 in material science, particularly in developing functionalized polymers and smart materials. The compound's ability to introduce both aromatic character and amine functionality makes it valuable for creating advanced polymeric systems with tailored properties.
Environmental and safety assessments of 2-(4-nitrophenoxy)ethanamine hydrochloride follow standard laboratory safety protocols. While not classified as hazardous under normal handling conditions, researchers should employ proper personal protective equipment (PPE) including gloves and safety glasses when working with this chemical.
The synthesis of 98395-62-1 typically involves nucleophilic aromatic substitution of 4-nitrophenol with 2-chloroethylamine hydrochloride, followed by purification. Process optimization studies continue to improve yields and reduce byproducts, reflecting the green chemistry principles increasingly important in modern chemical manufacturing.
Analytical method development for 2-(4-nitrophenoxy)ethanamine HCl remains an active research area, with recent advances in UHPLC techniques enabling faster and more precise quantification. These methods support quality control in both bulk manufacturing and research-scale applications.
In the context of drug delivery systems, derivatives of CAS 98395-62-1 have shown promise as linker molecules for antibody-drug conjugates (ADCs). This application capitalizes on the compound's ability to connect biological targeting moieties with therapeutic payloads, a hot topic in precision medicine research.
The spectroscopic properties of 2-(4-nitrophenoxy)ethanamine hydrochloride, particularly its UV-Vis absorption characteristics, make it useful as a chromophoric tag in analytical chemistry. Researchers utilize these properties for assay development and molecular tracking applications.
Looking ahead, the demand for high-purity 98395-62-1 is expected to grow in parallel with advancements in biopharmaceuticals and diagnostic reagents. Suppliers are responding by offering customized packaging options and technical support services to meet diverse research needs.
98395-62-1 (2-(4-Nitrophenoxy)ethanamine hydrochloride) Related Products
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