Production Method 1

5398-44-7

98027-80-6

Reaction Conditions

1.1 Reagents: 1,3-Dibromo-5,5-dimethylhydantoin ,  Pyridinium, 1-fluoro-2,4,6-trimethyl-, tetrafluoroborate(1-) (1:1) Catalysts: Tetrakis(acetonitrile)copper(1+) tetrafluoroborate Solvents: Acetonitrile ;  4 h, rt

Reference

Unified Approach to Decarboxylative Halogenation of (Hetero)aryl Carboxylic Acids

Chen, Tiffany Q.; Pedersen, P. Scott; Dow, Nathan W.; Fayad, Remi; Hauke, Cory E.; et al, Journal of the American Chemical Society (2022, 2022, 144(18), 8296-8305

4-Bromo-2,6-dichloropyridine Raw materials

• 2,6-dichloropyridine-4-carboxylic acid

4-Bromo-2,6-dichloropyridine Preparation Products

• 4-Bromo-2,6-dichloropyridine (98027-80-6)

• 1. An automated in-chip-catalytic–spectrophotometric method for determination of copper(ii) using a multisyringe flow injection analysis-multipumping flow system?
  Camelia Henríquez,Edwin Palacio,Víctor Cerdà Anal. Methods, 2014,6, 8494-8504
• 2. Aggregated-fluorescent detection of PFAS with a simple chip
  Cheng Fang,Jinjian Wu,Zahra Sobhani,Md. Al Amin,Youhong Tang Anal. Methods, 2019,11, 163-170
• 3. An apparatus for determining small amounts of alchohol in sour milk and urine
  Analyst, 1964,89, 272-275
• 4. An amphipathic trans-acting phosphorothioate RNA element delivers an uncharged phosphorodiamidate morpholino sequence in mdx mouse myotubes?
  H. V. Jain,D. Verthelyi,S. L. Beaucage RSC Adv., 2017,7, 42519-42528
• 5. Aggregation-induced emission based on a fluorinated macrocycle: visualizing spontaneous and ultrafast solid-state molecular motions at room temperature via F?F interactions?
  Mei Zhang,Jingjing Guo,Tingting Liu,Zhanyu He,Majeed Irfan,Zujin Zhao,Zhuo Zeng J. Mater. Chem. C, 2020,8, 14919-14924

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyridines and derivatives Halopyridines Polyhalopyridines
• Solvents and Organic Chemicals Organic Compounds

4-Bromo-2,6-Dichloropyridine: A Comprehensive Overview

4-Bromo-2,6-dichloropyridine (CAS No. 98027-80-6) is a heterocyclic aromatic compound with significant applications in various fields of chemistry. This compound, also referred to as 4-bromo-2,6-dichloropyridine, is characterized by its pyridine ring structure with bromine and chlorine substituents at specific positions. The unique electronic properties of this compound make it a valuable intermediate in the synthesis of diverse organic compounds, including agrochemicals, pharmaceuticals, and advanced materials.

Recent studies have highlighted the importance of 4-bromo-2,6-dichloropyridine in the development of novel herbicides. Researchers have explored its role as a precursor in the synthesis of pyridine-based herbicides, which are known for their effectiveness in controlling a wide range of weeds. For instance, a 2023 study published in the *Journal of Agricultural and Food Chemistry* demonstrated that derivatives of 4-bromo-2,6-dichloropyridine exhibit potent inhibitory activity against key enzymes involved in plant growth. This finding underscores the potential of this compound in sustainable agriculture practices.

In the field of materials science, 4-bromo-2,6-dichloropyridine has been utilized as a building block for the synthesis of advanced polymers and organic semiconductors. A 2023 paper in *Advanced Materials* reported that derivatives of this compound can be incorporated into polymer frameworks to enhance their electronic properties. These materials show promise for applications in flexible electronics and organic light-emitting diodes (OLEDs). The ability of 4-bromo-2,6-dichloropyridine to act as a versatile precursor makes it an indispensable tool in modern materials research.

The synthesis of 4-bromo-2,6-dichloropyridine involves a multi-step process that typically begins with the chlorination of pyridine derivatives. Recent advancements in catalytic methods have enabled more efficient and environmentally friendly routes to this compound. For example, researchers have employed palladium-catalyzed coupling reactions to achieve higher yields and better selectivity in its production. These improvements not only enhance the economic viability of large-scale production but also align with global sustainability goals.

From a pharmacological perspective, 4-bromo-2,6-dichloropyridine has been investigated for its potential as an intermediate in drug discovery. A 2023 study published in *Drug Discovery Today* highlighted its role in the synthesis of bioactive compounds targeting various disease states, including cancer and infectious diseases. The compound's ability to modulate cellular pathways makes it a valuable asset in medicinal chemistry.

In conclusion, 4-bromo-2,6-dichloropyridine (CAS No. 98027-80-6) is a versatile compound with far-reaching applications across multiple disciplines. Its role as an intermediate in agrochemicals, materials science, and pharmaceuticals underscores its importance in contemporary chemical research. As new studies continue to emerge, this compound is expected to contribute even more significantly to scientific advancements and technological innovations.

• 205055-63-6(6-Bromo-1-chloroisoquinoline)
• 552331-05-2(6-Bromo-1,3-dichloroisoquinoline)
• 924271-40-9(7-Bromo-1,3-dichloroisoquinoline)
• 73583-37-6(4-Bromo-2-chloropyridine)
• 1184917-16-5(4-bromo-2,5-dichloro-pyridine)
• 1029720-67-9(5-Bromo-3-chloroisoquinoline)
• 1233025-78-9(8-bromo-1-chloro-isoquinoline)
• 552331-06-3(6-Bromo-3-chloroisoquinoline)
• 53939-30-3(5-Bromo-2-chloropyridine)
• 215453-51-3(7-Bromo-1-Chloroisoquinoline)