Production Method 1

87-65-0

97608-49-6

Reaction Conditions

1.1 Reagents: Hydrofluoric acid ;  rt → 150 °C; 15 h, 150 °C

Reference

Process for preparation of 2,6-dihalo-3-nitro-1-(trifluoromethoxy)benzene

, China, , ,

Production Method 2

2211018-01-6

97608-49-6

451-85-4

Reaction Conditions

1.1 Catalysts: Tris(2,2′-bipyridine)ruthenium(2+) bis(hexafluorophosphate) Solvents: Acetonitrile ;  16 h, rt

Reference

Catalytic C-H Trifluoromethoxylation of Arenes and Heteroarenes

Zheng, Weijia ; Morales-Rivera, Cristian A.; Lee, Johnny W. ; Liu, Peng ; Ngai, Ming-Yu, Angewandte Chemie, 2018, 57(31), 9645-9649

Production Method 3

97608-48-5

97608-49-6

Reaction Conditions

1.1 Reagents: Hydrofluoric acid

Reference

A safe and economical synthesis of 3-(trifluoromethoxy)aniline from 2-chlorophenol

Langlois, Bernard; Soula, Gerard, Bulletin de la Societe Chimique de France, 1986, (6), 925-9

Production Method 4

97608-48-5

97608-49-6

Reaction Conditions

1.1 Reagents: Hydrofluoric acid

Reference

Synthesis and properties of aryl polyfluoromethyl ethers and thio ethers

Langlois, B.; Desbois, M., Annales de Chimie (Paris, 1984, 9(6), 729-41

Production Method 5

97608-49-6

Reaction Conditions

Reference

m-Substituted anilines

, European Patent Organization, , ,

Production Method 6

2211018-01-6

97608-49-6

451-85-4

Reaction Conditions

1.1 Catalysts: Tris(2,2′-bipyridine)ruthenium(2+) bis(hexafluorophosphate) Solvents: Acetonitrile ;  16 h, rt

Reference

Preparation of redox-active reagents for the ruthenium-catalyzed difluoromethoxylation and trifluoromethoxylation of arenes and heteroarenes under visible light

, World Intellectual Property Organization, , ,

1,3-Dichloro-2-(trifluoromethoxy)benzene Raw materials

• Benzene, 1,3-dichloro-2-(trichloromethoxy)-
• 2,6-Dichlorophenol
• 1H-Benzimidazole, 2-[3,5-bis(trifluoromethyl)phenyl]-4-nitro-1-(trifluoromethoxy)-6-(trifluoromethyl)-

1,3-Dichloro-2-(trifluoromethoxy)benzene Preparation Products

• 2,4-Dichloro-1-(trifluoromethoxy)benzene (451-85-4)
• 1,3-Dichloro-2-(trifluoromethoxy)benzene (97608-49-6)

• 1. Acentric and chiral heterometallic inorganic–organic hybrid frameworks mediated by alkali or alkaline earth ions: synthesis and NLO properties
  Huabin Zhang,Shaowu Du CrystEngComm, 2014,16, 4059-4068
• 2. An atmosphere and light tuned highly diastereoselective synthesis of cyclobuta/penta[b]indoles from aniline-tethered alkylidenecyclopropanes with alkynes?
  Bo Cao,Yin Wei Chem. Commun., 2018,54, 2870-2873
• 3. An ionic liquid loaded magnetically confined polymeric mesoporous adsorbent for extraction of parabens from environmental and cosmetic samples?
  Masrudin Md Yusoff,Muggundha Raoov,Noorfatimah Yahaya,Noorashikin Md Salleh RSC Adv., 2017,7, 35832-35844
• 4. An artificial enzyme cascade amplification strategy for highly sensitive and specific detection of breast cancer-derived exosomes?
  Huiying Xu,Lu Zheng,Yu Zhou,Bang-Ce Ye Analyst, 2021,146, 5542-5549
• 5. An approach to C–N activation: coupling of arenesulfonyl hydrazides and arenesulfonyl chlorides with tert-amines via a metal-, oxidant- and halogen-free anodic oxidation??
  M. Sheykhan,S. Khani,S. Shaabanzadeh,M. Joafshan Green Chem., 2017,19, 5940-5948

• 886500-85-2(4-Chloro-3-(trifluoromethoxy)phenol)
• 451-85-4(2,4-Dichloro-1-(trifluoromethoxy)benzene)
• 653578-81-5(Phenol, 2-chloro-3-(trifluoromethoxy)-)
• 1034669-92-5(2-Chloro-4-methoxy-1-(trifluoromethoxy)benzene)
• 63165-19-5(BENZENE, 1,3-DICHLORO-2,4-BIS(TRIFLUOROMETHOXY)-)
• 1000339-94-5(3-Chloro-4-(trifluoromethoxy)phenol)
• 450-96-4(1-Chloro-2-(trifluoromethoxy)benzene)
• 772-23-6(Benzene, 2,4-dichloro-1-(difluoromethoxy)-)
• 63165-14-0(Benzene, 1,4-dichloro-2,5-bis(trifluoromethoxy)-)
• 151276-11-8(Benzene, 1,4-dichloro-2-(trifluoromethoxy)-)