Production Method 1

1457-58-5

97602-72-7

Reaction Conditions

1.1 Reagents: Sulfuric acid Solvents: Methanol ;  > 1 min, rt; rt → reflux; 24 h, reflux
1.2 Reagents: Sulfuric acid ;  reflux; 24 h, reflux; reflux → rt
1.3 Reagents: Sodium hydroxide Solvents: Water ;  pH 9, rt

Reference

Preparation of heterocyclyl-butanamide derivatives as Tankyrase inhibitors

, World Intellectual Property Organization, , ,

Production Method 2

1457-58-5

97602-72-7

Reaction Conditions

1.1 Reagents: Hydrochloric acid Solvents: Methanol ;  12 h, 80 °C
1.2 Reagents: Sodium bicarbonate Solvents: Water ;  pH 8

Reference

Preparation of carboxamides as calpain modulators and therapeutic uses thereof

, World Intellectual Property Organization, , ,

Production Method 3

22059-22-9

922-67-8

97602-72-7

Reaction Conditions

1.1 Solvents: Methanol ;  4 h, reflux

Reference

Imidazotriazine derivatives as PDE10 inhibitors and their preparation

, World Intellectual Property Organization, , ,

Production Method 4

586966-00-9

97602-72-7

Reaction Conditions

Reference

Product class 3: imidazoles

Grimmett, M. R., Science of Synthesis, 2002, 12, 325-528

Production Method 5

97602-58-9

97602-72-7

Reaction Conditions

1.1 Solvents: Methanol

Reference

Two-step synthesis of imidazoles from activated alkynes

Casey, Michael; Moody, Christopher J.; Rees, Charles W.; Young, Richard G., Journal of the Chemical Society, 1985, (1985), 741-5

Production Method 6

97602-72-7

Reaction Conditions

Reference

Preparation of bicyclic heteroaromatic amide compounds and uses thereof

, World Intellectual Property Organization, , ,

Methyl 2-methyl-1H-imidazole-5-carboxylate Raw materials

• N-hydroxyethanimidamide
• 2-methyl-1H-imidazole-5-carboxylic acid
• methyl prop-2-ynoate
• 1H-Tetrazole-1-aceticacid,5-methyl-alpha-methylene-,methylester(9CI)
• 2-Propenoic acid, 3-(5-methyl-1H-tetrazol-1-yl)-, methyl ester, (E)-

Methyl 2-methyl-1H-imidazole-5-carboxylate Preparation Products

• Methyl 2-methyl-1H-imidazole-5-carboxylate (97602-72-7)

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• 87326-25-8(2-Methyl-1H-imidazole-4-carboxylic acid ethyl ester)
• 102625-28-5(1H-Imidazole-5-carboxylicacid, 2-(methoxymethyl)-)
• 144167-57-7(1H-Imidazole-2,5-dicarboxylicacid, 2-ethyl 5-methyl ester)
• 127607-71-0(methyl 1H-imidazole-5-carboxylate;hydrochloride)
• 17325-26-7(Methyl 1H-imidazole-5-carboxylate)
• 23785-21-9(ethyl 1H-imidazole-5-carboxylate)
• 500890-03-9(ethyl 2,5-dimethyl-1H-imidazole-4-carboxylate)
• 65611-53-2(1H-Imidazole-4,5-dicarboxylic acid, 2-methyl-, diethyl ester)
• 701292-71-9(1H-Imidazole-5-carboxylicacid, 2-(methoxymethyl)-, methyl ester)
• 773138-27-5(1H-Imidazole-5-carboxylicacid, 2-ethyl-, ethyl ester)