Production Method 1

1009-36-5

97459-72-8

Reaction Conditions

1.1 Reagents: Sodium carbonate Catalysts: Polyethylene glycol (polymer-supported)

Reference

Application of polystyrene-supported polyethylene glycol in organic synthesis (II).

Yu, Shanxin; Liu, Wenqi, Lizi Jiaohuan Yu Xifu, 1992, 8(3), 211-16

Production Method 2

454-16-0

97459-72-8

Reaction Conditions

1.1 Reagents: Potassium carbonate Solvents: Dimethylformamide ;  6 h, 80 °C

Reference

Preparation of imidazopyridazine compounds useful as IRAK4 inhibitors

, China, , ,

Production Method 3

1009-36-5

97459-72-8

Reaction Conditions

1.1 15 h, 120 °C

Reference

Preparation of N-acylazetidine MEK inhibitors and 4-aryl-2-aminopyrimidine or 4-aryl-2-aminoalkylpyrimidine JAK-2 inhibitors and their combinations useful for treating neoplasm

, World Intellectual Property Organization, , ,

Production Method 4

1009-36-5

97459-72-8

Reaction Conditions

1.1 15 h, 120 °C

Reference

4-Aryl-2-aminopyrimidines or 4-aryl-2-aminoalkylpyrimidines as JAK-2 modulators and their preparation, pharmaceutical compositions and use in the treatment of diseases

, World Intellectual Property Organization, , ,

Production Method 5

77337-82-7

97459-72-8

Reaction Conditions

1.1 Reagents: Potassium carbonate Solvents: Dimethylformamide

Reference

Synthesis of heterocyclic spleen tyrosine kinase inhibitors treating cancers, inflammatory, allergic or autoimmune diseases

, World Intellectual Property Organization, , ,

Production Method 6

1009-36-5

97459-72-8

Reaction Conditions

1.1 Solvents: Dimethyl sulfoxide ;  overnight, 100 °C

Reference

Preparation of oxazolidinone derivatives as anticoagulants

, Japan, , ,

Production Method 7

77337-82-7

97459-72-8

Reaction Conditions

1.1 Reagents: Sodium tert-butoxide Catalysts: Tris(dibenzylideneacetone)dipalladium ,  BINAP Solvents: Toluene ;  10 min, 20 °C; 3 h, 80 °C

Reference

Preparation of 2-amino-4-heteroarylaminopyrimidine derivatives as IGF-1R kinase inhibitors for use in the treatment of cancer

, World Intellectual Property Organization, , ,

Production Method 8

77337-82-7

97459-72-8

Reaction Conditions

1.1 Reagents: Sodium tert-butoxide Catalysts: Tris(dibenzylideneacetone)dipalladium ,  (+)-BINAP Solvents: Toluene ;  10 min, 20 °C

Reference

Preparation of 2,4-disubstituted amino pyrimidinyl derivatives for use as anticancer agents

, World Intellectual Property Organization, , ,

Production Method 9

77337-82-7

97459-72-8

Reaction Conditions

1.1 overnight, 130 °C

Reference

Preparation of morpholinylanilino quinazoline derivatives for use as antiviral agents

, World Intellectual Property Organization, , ,

Production Method 10

77337-82-7

97459-72-8

Reaction Conditions

1.1 Reagents: Potassium carbonate Solvents: Dimethylformamide ;  48 h, 110 °C

Reference

Pyrrolones and pyrrolidinones as melanin concentrating hormone receptor-1 antagonists and their preparation

, World Intellectual Property Organization, , ,

Production Method 11

454-16-0

97459-72-8

Reaction Conditions

1.1 Reagents: Potassium carbonate Solvents: Dimethylformamide ;  6 h, 80 °C

Reference

Preparation of FLT3 kinase inhibitor for treating FLT3 mediated diseases

, China, , ,

Production Method 12

1009-36-5

97459-72-8

Reaction Conditions

1.1 15 h, 120 °C

Reference

Pyrimidine derivatives as JAK-2 inhibitors in combination with other agents and their preparation and use in the treatment of diseases

, World Intellectual Property Organization, , ,

Production Method 13

77337-82-7

97459-72-8

Reaction Conditions

1.1 Reagents: Sodium tert-butoxide Catalysts: Tris(dibenzylideneacetone)dipalladium ,  BINAP Solvents: Toluene ;  3 h, 80 °C

Reference

Discovery of 2,4-bis-arylamino-1,3-pyrimidinebis-arylamino-1,3-pyrimidines as insulin-like growth factor-1 receptor (IGF-1R) inhibitors

Buchanan, John L.; Newcomb, John R.; Carney, David P.; Chaffee, Stuart C.; Chai, Lilly; et al, Bioorganic & Medicinal Chemistry Letters, 2011, 21(8), 2394-2399

Production Method 14

77337-82-7

97459-72-8

Reaction Conditions

1.1 Reagents: Sodium tert-butoxide Catalysts: Bis(dibenzylideneacetone)palladium ,  BINAP Solvents: Toluene ;  rt; 7 h, 80 °C

Reference

Preparation of thieno[3,2-d]pyrimidine-2,4-diamine derivatives as Syk kinase inhibitors

, Japan, , ,

Production Method 15

1009-36-5

97459-72-8

Reaction Conditions

1.1 rt → 120 °C; 15 h, 120 °C

Reference

preparation of pyrimidine derivatives as LRRK2 inhibitors

, World Intellectual Property Organization, , ,

Production Method 16

1009-36-5

97459-72-8

Reaction Conditions

1.1 4 h, rt → 100 °C; 100 °C → rt

Reference

Preparation of thiazolopyridinones as MCH receptor antagonists for treating and preventing symptoms associated with obesity and related diseases

, World Intellectual Property Organization, , ,

Production Method 17

454-16-0

97459-72-8

Reaction Conditions

1.1 Reagents: Potassium carbonate Solvents: Dimethylformamide ;  4 h, 80 °C

Reference

Preparation of imidazopyrazine Syk inhibitors

, World Intellectual Property Organization, , ,

Production Method 18

454-16-0

97459-72-8

Reaction Conditions

1.1 Reagents: Potassium carbonate Solvents: Dimethylformamide ;  48 h, rt

Reference

Preparation of fused bicyclic derivatives of 2,4-diaminopyrimidine as ALK and c-Met kinase inhibitors

, World Intellectual Property Organization, , ,

4-(2-Methoxy-4-nitrophenyl)morpholine Raw materials

• 1-fluoro-2-methoxy-4-nitro-benzene
• 2-Bromo-5-nitroanisole
• 2-Chloro-5-nitroanisole

4-(2-Methoxy-4-nitrophenyl)morpholine Preparation Products

• 4-(2-Methoxy-4-nitrophenyl)morpholine (97459-72-8)

• 1. Emulsifier-free, organotellurium-mediated living radical emulsion polymerization (emulsion TERP) of styrene: poly(dimethylaminoethyl methacrylate) macro-TERP agent?
  Yukiya Kitayama Polym. Chem., 2014,5, 2784-2792
• 2. Fe3O4/PEG-SO3H as a heterogeneous and magnetically-recyclable nanocatalyst for the oxidation of sulfides to sulfones or sulfoxides
  Saeideh Mirfakhraei,Malak Hekmati,Fereshteh Hosseini Eshbala,Hojat Veisi New J. Chem., 2018,42, 1757-1761
• 3. Excellent mechanical performance and enhanced dielectric properties of OBC/SiO2 elastomeric nanocomposites: effect of dispersion of the SiO2 nanoparticles?
  Xing Zhao,Lu Bai,Rui-Ying Bao,Zheng-Ying Liu,Ming-Bo Yang,Wei Yang RSC Adv., 2017,7, 46297-46305
• 4. Evidence of CO2 molecule acting as an electron acceptor on a nanoporous metal–organic-framework MIL-53 or Cr3+(OH)(O2C–C6H4–CO2)?
  Alexandre Vimont,Arnaud Travert,Philippe Bazin,Jean-Claude Lavalley,Marco Daturi,Christian Serre,Gérard Férey,Sandrine Bourrelly,Philip L. Llewellyn Chem. Commun., 2007, 3291-3293
• 5. Fe3O4 nanoparticle chains with N-doped carbon coating: magnetotactic bacteria assisted synthesis and high-rate lithium storage?
  Dan Yang,Yanping Zhou,Xianhong Rui,Jixin Zhu,Ziyang Lu,Eileen Fong,Qingyu Yan RSC Adv., 2013,3, 14960-14962

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Oxazinanes Phenylmorpholines
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Oxazinanes Morpholines Phenylmorpholines

• 86-15-7(Morpholine,4-(2,5-dibutoxy-4-nitrophenyl)-)
• 383870-96-0(4-(4-Methoxy-3-nitrophenyl)morpholine)
• 66095-81-6(2-[(2-methoxy-4-nitrophenyl)amino]ethanol)
• 86-16-8(4-(2,5-Diethoxy-4-nitrophenyl)morpholine)
• 59411-71-1(4-(2,5-dimethoxy-4-nitrophenyl)morpholine)
• 6950-88-5(Morpholine,4-(3-methoxy-4-nitrophenyl)-)
• 175135-19-0(5-Morpholino-2-nitrophenol)
• 68400-49-7(4-[2,5-bis(1-methylethoxy)-4-nitrophenyl]morpholine)
• 113342-99-7(Ethanol, 2,2'-[(2-methoxy-4-nitrophenyl)imino]bis-)
• 120711-93-5(2H-1,4-Benzoxazine, 3,4-dihydro-4-methyl-7-nitro-)