Production Method 1

197507-22-5

96740-92-0

Reaction Conditions

1.1 Reagents: Lithium aluminum hydride Solvents: Tetrahydrofuran ;  45 min, rt
1.2 Reagents: Ethyl acetate ,  Hydrochloric acid ,  Water

Reference

Synthesis and structure-activity relationship studies of derivatives of the dual aromatase-sulfatase inhibitor 4-{[(4-cyanophenyl)(4H-1,2,4-triazol-4-yl)amino]methyl}phenyl sulfamate

Woo, L. W. Lawrence; Wood, Paul M.; Bubert, Christian; Thomas, Mark P.; Purohit, Atul; et al, ChemMedChem, 2013, 8(5), 779-799

Production Method 2

348-27-6

96740-92-0

Reaction Conditions

1.1 Reagents: Sodium borohydride Solvents: Methanol ;  2 h, rt

Reference

Circumventing Seizure Activity in a Series of G Protein Coupled Receptor 119 (GPR119) Agonists

Scott, James S.; Bowker, Suzanne S.; Brocklehurst, Katy J.; Brown, Hayley S.; Clarke, David S.; et al, Journal of Medicinal Chemistry, 2014, 57(21), 8984-8998

Production Method 3

65145-13-3

96740-92-0

Reaction Conditions

1.1 Reagents: Lithium aluminum hydride Solvents: Tetrahydrofuran ;  0 °C; 3 h, 0 °C
1.2 Reagents: Sodium hydroxide Solvents: Ethyl acetate ,  Water ;  0 °C

Reference

Piperidine compound containing 1-oxido-thiazole moiety as GPR119 agonist and preparation method thereof

, Korea, , ,

Production Method 4

65145-13-3

96740-92-0

Reaction Conditions

1.1 Reagents: Lithium aluminum hydride Solvents: Tetrahydrofuran ;  0 °C; > 3 h, rt

Reference

Substituted piperidine derivatives as a GPR119 agonist useful in treatment of metabolism related diseases and their preparation

, World Intellectual Property Organization, , ,

Production Method 5

348-27-6

96740-92-0

Reaction Conditions

1.1 Reagents: Sodium borohydride Solvents: Methanol ;  10 min, rt

Reference

Electronically modified polymer-supported cinchona phase-transfer catalysts for asymmetric synthesis of α-alkyl-α-amino acid derivatives

Shi, Qinghua; Lee, Yeon-Ju; Song, Hongrui; Cheng, Maosheng; Jew, Sang-sup; et al, Chemistry Letters, 2008, 37(4), 436-437

Production Method 6

65145-13-3

96740-92-0

Reaction Conditions

1.1 Reagents: (Dimethyl sulfide)trihydroboron Solvents: Tetrahydrofuran ;  rt
1.2 Reagents: Methanol

Reference

Compounds directed against pilus biogenesis and activity in pathogenic bacteria; methods and compositions for synthesis

, World Intellectual Property Organization, , ,

Production Method 7

65145-13-3

96740-92-0

Reaction Conditions

1.1 Reagents: Trimethyl borate Solvents: Tetrahydrofuran
1.2 Solvents: Methanol

Reference

Preparation of Fluorinated Linkers: Use of 19F NMR Spectroscopy to Establish Conditions for Solid-Phase Synthesis of Pilicide Libraries

Svensson, Anette; Fex, Tomas; Kihlberg, Jan, Journal of Combinatorial Chemistry, 2000, 2(6), 736-748

Production Method 8

372-20-3

96740-92-0

Reaction Conditions

1.1 Reagents: Potassium hydroxide Solvents: Water ;  1 h, 60 °C
1.2 Solvents: Water ;  60 °C → 40 °C; 18 h, 40 °C; 40 °C → rt
1.3 Reagents: Hydrochloric acid Solvents: Water

Reference

Preparation of piperazines for treating disorders associated with the 5-HT2 receptor

, World Intellectual Property Organization, , ,

Production Method 9

65145-13-3

96740-92-0

Reaction Conditions

1.1 Reagents: Lithium aluminum hydride Solvents: Tetrahydrofuran ;  rt → 0 °C; 0 °C → rt; 3 h, rt

Reference

Piperazine derivative as GPR119 activator and method for the preparation thereof

, Korea, , ,

Production Method 10

65145-13-3

96740-92-0

Reaction Conditions

1.1 Reagents: Lithium aluminum hydride Solvents: Tetrahydrofuran ;  0 °C; > 3 h, rt

Reference

Preparation of substituted piperidine derivatives as GPR119 agonists

, Korea, , ,

Production Method 11

96740-92-0

Reaction Conditions

Reference

Fluorinated linkers for monitoring solid-phase synthesis using gel-phase 19F NMR spectroscopy

Svensson, Anette; Bergquist, Karl-Erik; Fex, Tomas; Kihlberg, Jan, Tetrahedron Letters, 1998, 39(39), 7193-7196

2-Fluoro-4-hydroxybenzenemethanol Raw materials

• 2-Fluoro-4-hydroxybenzoic Acid
• 2-Fluoro-4-hydroxybenzaldehyde
• 3-Fluorophenol
• Methyl 2-fluoro-4-hydroxybenzoate

2-Fluoro-4-hydroxybenzenemethanol Preparation Products

• 2-Fluoro-4-hydroxybenzenemethanol (96740-92-0)

• 1. An amphipathic trans-acting phosphorothioate RNA element delivers an uncharged phosphorodiamidate morpholino sequence in mdx mouse myotubes?
  H. V. Jain,D. Verthelyi,S. L. Beaucage RSC Adv., 2017,7, 42519-42528
• 2. An asymmetric supercapacitor based on controllable WO3 nanorod bundle and alfalfa-derived porous carbon?
  Kanjun Sun,Fengting Hua,Shuzhen Cui,Yanrong Zhu,Hui Peng,Guofu Ma RSC Adv., 2021,11, 37631-37642
• 3. An Assessment of the Laminar Hypersonic Double-Cone Experiments in the LENS-XX Tunnel
  JaideepRay,PatrickBlonigan,EricT.Phipps,KathrynMaupin
• 4. An integrated droplet-digital microfluidic system for on-demand droplet creation, mixing, incubation, and sorting?
  Lab Chip, 2019,19, 524-535
• 5. An amorphous carbon nitride/NiO/CoN-based composite: a highly efficient nonprecious electrode for supercapacitors and the oxygen evolution reaction?
  Huifang Yang,Haoran Guo,Peidong Fan,Xinpan Li,Wenlu Ren,Rui Song Nanoscale, 2020,12, 7024-7034

• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Benzyl alcohols

• 89735-30-8(1,2-Benzenediol, 4-fluoro-5-(hydroxymethyl)-)
• 79538-27-5(2,6-Difluoro-4-methoxybenzyl alcohol)
• 161643-29-4(2-Fluoro-5-methoxybenzyl Alcohol)
• 405-09-4((2-Fluoro-4-methoxyphenyl)methanol)
• 61596-38-1(Benzenemethanol, 2,3,5,6-tetrafluoro-4-hydroxy-)
• 504414-33-9(Benzenemethanol, 2-fluoro-4-(phenylmethoxy)-)
• 452-78-8(3-Fluoro-4-methylphenol)
• 253166-66-4(Benzenemethanol,2-fluoro-4-hydroxy-a-methyl-)
• 438049-36-6(2,6-Difluoro-4-hydroxybenzyl alcohol)
• 89735-28-4(1,2-Benzenediol, 3-fluoro-4-(hydroxymethyl)-)