Production Method 1

765-30-0

58986-28-0

96568-08-0

Reaction Conditions

1.1 Solvents: Diisopropyl ether ;  rt → reflux; 1.5 h, reflux; 4.5 h, reflux

Reference

Process for preparation of β-(cyclopropylamino)acrylic acid esters

, China, , ,

Production Method 2

623-47-2

765-30-0

96568-08-0

Reaction Conditions

Reference

Synthesis of ethyl 3-cyclopropylaminoacrylate

Yang, Yongzheng; Gao, Yun; Li, Shaoxin, Zhongguo Yiyao Gongye Zazhi, 1992, 23(12),

Production Method 3

109-94-4

5687-85-4

765-30-0

96568-08-0

Reaction Conditions

1.1 Reagents: Sodium ethoxide Solvents: Toluene ;  6 h, 8 atm, 70 °C; 70 °C → 0 °C
1.2 Solvents: Toluene ;  35 min, 2 °C

Reference

Process for preparation of 2-substituted-3-(N,N-disubstituted-amino)acrylates

, World Intellectual Property Organization, , ,

Production Method 4

109-94-4

765-30-0

96568-08-0

Reaction Conditions

1.1 Reagents: Carbon dioxide ;  1 - 2 atm, 60 °C
1.2 Reagents: Sodium ethoxide Solvents: Toluene ;  8 atm, rt → 70 °C; 6 h, 8 atm, 70 °C; 70 °C → 0 °C
1.3 Solvents: Toluene ;  35 min, 2 °C

Reference

Process for preparation of 2-substituted-3-(N,N-disubstituted-amino)acrylates

, China, , ,

Production Method 5

623-47-2

765-30-0

96568-08-0

Reaction Conditions

Reference

Synthesis of 4H-1,4-benzothiazine 1-oxide and 1,1-dioxide. Analogs of quinoline antibacterial agents

Culbertson, Townley P., Journal of Heterocyclic Chemistry, 1991, 28(7), 1701-3

Production Method 6

96568-08-0

Reaction Conditions

Reference

Quinoline derivatives of β-lactams as antimicrobial compounds

, World Intellectual Property Organization, , ,

2-Propenoic acid,3-(cyclopropylamino)-, ethyl ester Raw materials

• Ethyl formate
• Carbamic acid, cyclopropyl-
• ethyl propiolate
• cyclopropanamine
• sodium;ethyl 3-oxopropanoate

2-Propenoic acid,3-(cyclopropylamino)-, ethyl ester Preparation Products

• 2-Propenoic acid,3-(cyclopropylamino)-, ethyl ester (96568-08-0)

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• 3. Evidence that the availability of an allylic hydrogen governs the regioselectivity of the Wacker oxidation
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