Production Method 1

676-58-4

775-16-6

96567-93-0

Reaction Conditions

1.1 Solvents: Diethyl ether ,  Tetrahydrofuran ;  rt → -70 °C; 2 min, -70 °C; -70 °C → rt; overnight, rt
1.2 Reagents: Ammonium chloride Solvents: Water

Reference

Piperidinyl pyrrolidinyl methanone compounds as renin inhibitors and their preparation, pharmaceutical compositions and use in the treatment of diseases associated with aspartic protease activity

, World Intellectual Property Organization, , ,

Production Method 2

775-16-6

96567-93-0

Reaction Conditions

1.1 Solvents: Tetrahydrofuran ;  -20 °C; -20 °C → rt
1.2 Reagents: Water

Reference

Triazolopyridine compounds as PIM kinase inhibitors and their preparation

, World Intellectual Property Organization, , ,

Production Method 3

775-16-6

96567-93-0

Reaction Conditions

1.1 Solvents: Tetrahydrofuran ;  0 °C

Reference

Pharmacophore modal-based design and synthesis of new structure small molecule CCR2 inhibitors

Qin, Lihuai; Li, Xiaoguang; Wang, Zhilong; Yao, Wenbo; Wang, Hui; et al, Huaxue Xuebao, 2015, 73(7), 679-684

Production Method 4

676-58-4

775-16-6

96567-93-0

Reaction Conditions

Reference

Preparation of substituted pyrazole derivatives for use as CCR-2 and CCR-5 receptor antagonists

, World Intellectual Property Organization, , ,

Production Method 5

775-16-6

96567-93-0

Reaction Conditions

1.1 Solvents: Diethyl ether ,  Tetrahydrofuran ;  3 h, -20 °C; -20 °C → 0 °C

Reference

Preparation of 1-(hetero)aryl-3-amino-pyrrolidine derivatives as mGluR3 receptor antagonists

, World Intellectual Property Organization, , ,

Production Method 6

96567-93-0

Reaction Conditions

Reference

On the Ritter reaction of cyclic hydroxyamines: synthesis of conformationally-restricted reduced amide dipeptide isosteres

Taylor, G. Mark; Baker, Stewart J.; Gedney, Andrea; Pearson, David J.; Sibley, Graham E. M., Tetrahedron Letters, 1996, 37(8), 1297-300

Production Method 7

96567-93-0

Reaction Conditions

Reference

1,8-Naphthyridine derivatives

, European Patent Organization, , ,

Production Method 8

676-58-4

775-16-6

96567-93-0

Reaction Conditions

1.1 Solvents: Diethyl ether ,  Tetrahydrofuran ;  rt → -70 °C; 2 min, -70 °C; overnight, rt
1.2 Reagents: Ammonium chloride Solvents: Water

Reference

Acylpiperidine compounds as renin inhibitors and their preparation, pharmaceutical compositions and use in the treatment of diseases associated with aspartic protease activity

, World Intellectual Property Organization, , ,

Production Method 9

775-16-6

96567-93-0

Reaction Conditions

1.1 Solvents: Tetrahydrofuran ;  3 h, -20 °C

Reference

1,4-Dihydropyridine-3,5-dicarboxylate derivatives as calcium channel blockers and their preparation, pharmaceutical compositions and use in the treatment of diseases

, World Intellectual Property Organization, , ,

Production Method 10

775-16-6

96567-93-0

Reaction Conditions

1.1 Solvents: Tetrahydrofuran ;  0 °C; 1 h, 0 °C
1.2 Reagents: Ammonium chloride Solvents: Water

Reference

Discovery of Fragment-Derived Small Molecules for in Vivo Inhibition of Ketohexokinase (KHK)

Huard, Kim ; Ahn, Kay; Amor, Paul; Beebe, David A.; Borzilleri, Kris A.; et al, Journal of Medicinal Chemistry, 2017, 60(18), 7835-7849

Production Method 11

775-16-6

96567-93-0

Reaction Conditions

1.1 Solvents: Diethyl ether ,  Toluene ,  Tetrahydrofuran ;  1.5 h, 0 °C
1.2 Reagents: Water

Reference

[(Pyrimidinylhydrazino)-3-oxopropyl]hydroxyformamide derivatives as bacterial peptide deformylase inhibitors and preparation, pharmaceutical compositions and use in the treatment of bacterial infections

, World Intellectual Property Organization, , ,

Production Method 12

775-16-6

96567-93-0

Reaction Conditions

1.1 Solvents: Diethyl ether ,  Tetrahydrofuran ;  0 °C; 40 min, 0 °C
1.2 Reagents: Ammonium chloride Solvents: Water

Reference

Aminopyrimidine derivatives as kinase inhibitors and their preparation, pharmaceutical compositions and use in the treatment of cancer

, World Intellectual Property Organization, , ,

Production Method 13

775-16-6

96567-93-0

Reaction Conditions

1.1 Solvents: Diethyl ether ,  Tetrahydrofuran ;  rt → -70 °C; 5 min, -70 °C; -70 °C → rt; overnight, rt
1.2 Reagents: Ammonium chloride Solvents: Water

Reference

Preparation of adamantylpyrrolidinecarboxylate derivatives and analogs for use as 11-beta-hydroxysteroid dehydrogenase 1 inhibitors

, World Intellectual Property Organization, , ,

Production Method 14

775-16-6

96567-93-0

Reaction Conditions

1.1 Solvents: Diethyl ether ,  Tetrahydrofuran ;  0 °C; 1 h, 0 °C
1.2 Reagents: Water Solvents: Diethyl ether

Reference

Preparation of quinolinecarboxyamide derivatives for use in the treatment of inflammatory diseases

, World Intellectual Property Organization, , ,

1-Benzyl-3-methylpyrrolidin-3-ol Raw materials

• Methylmagnesium Chloride (3M in THF)
• 1-benzylpyrrolidin-3-one

1-Benzyl-3-methylpyrrolidin-3-ol Preparation Products

• 1-Benzyl-3-methylpyrrolidin-3-ol (96567-93-0)

• 1. Exceptional activity of sub-nm Pt clusters on CdS for photocatalytic hydrogen production: a combined experimental and first-principles study?
  Qiyuan Wu,Shangmin Xiong,Peichuan Shen,Shen Zhao,Alexander Orlov Catal. Sci. Technol., 2015,5, 2059-2064
• 2. Establishment and implications of a characterization method for magnetic nanoparticle using cell tracking velocimetry and magnetic susceptibility modified solutions
  Huading Zhang,Lee R. Moore,Maciej Zborowski,P. Stephen Williams,Shlomo Margel,Jeffrey J. Chalmers Analyst, 2005,130, 514-527
• 3. Excellent kinetics of single-phase Gd-doped ceria fuel electrodes in solid oxide cells?
  Andreas Nenning,Manuel Holzmann,Jürgen Fleig,Alexander K. Opitz Mater. Adv., 2021,2, 5422-5431
• 4. Excess electrons in lithium–ethylamine solutions—density, electrical conductivity and EPR studies
  Phys. Chem. Chem. Phys., 1999,1, 3561-3565
• 5. Exchanged ligands on the surface of a giant cluster: [(MoO3)176(H2O)63(CH3OH)17Hn](32 – n)–
  Chem. Commun., 1998, 1501-1502

• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Phenylmethylamines

• 144043-26-5(3-Pyrrolidinol, 4,4-dimethyl-1-(phenylmethyl)-, (3S)-)
• 137172-64-6((3R,4S)-1-benzyl-4-methylpyrrolidin-3-ol)
• 620536-51-8(3-Pyrrolidinol,3-ethyl-4-methyl-1-(phenylmethyl)-,(3R,4S)-rel-(9CI))
• 637038-98-3(3-Pyrrolidinol, 3-[[(2-hydroxyethyl)amino]methyl]-1-(phenylmethyl)-)
• 143728-93-2(trans-1-Benzyl-4-methyl-pyrrolidin-3-ol)
• 125033-36-5(3-(Aminomethyl)-1-benzylpyrrolidin-3-ol)
• 151096-94-5(4-PIPERIDINOL, 1-(PHENYLMETHYL)-4-[[(PHENYLMETHYL)AMINO]METHYL]-)
• 1393732-45-0(1-Benzyl-3-(hydroxymethyl)pyrrolidin-3-ol)
• 144124-87-8(3-Pyrrolidinol, 4-methyl-1-(phenylmethyl)-, trans-(±)-)
• 137172-65-7((3S,4R)-1-benzyl-4-methylpyrrolidin-3-ol)