Production Method 1

111842-06-9

96562-58-2

Reaction Conditions

1.1 Reagents: Hydrochloric acid Solvents: Methanol

Reference

Preparation of (R)- and (S)-2-(4-acylphenoxy)propanoates by Friedel-Crafts acylation of (R)- or (S)-2-phenoxypropanoates.

, World Intellectual Property Organization, , ,

Production Method 2

73246-45-4

96562-58-2

Reaction Conditions

1.1 Reagents: Sodium hydroxide Solvents: Water ;  25 °C
1.2 25 °C

Reference

Process for the preparation of methyl (R)-(+)-2-(4-hydroxyphenoxy)propionate

, China, , ,

Production Method 3

71283-66-4

96562-58-2

Reaction Conditions

1.1 Reagents: Sodium methoxide Solvents: Methanol ;  30 min, rt
1.2 Solvents: Methanol ;  rt; rt → 40 °C; 24 h, 40 °C
1.3 Reagents: Hydrochloric acid Solvents: Water ;  pH 1

Reference

Synthesis and crystal structure of R-(+)-2-(4-hydroxyphenoxy)-propionate derivatives

Han, Cui-ping; Sun, Jie; Huang, Tong-hui, Huaxue Shiji, 2015, 37(4), 354-356

Production Method 4

63696-98-0

96562-58-2

Reaction Conditions

1.1 Reagents: Potassium carbonate Solvents: Dimethylformamide ;  12 h, 60 °C

Reference

Method for preparing compound

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Production Method 5

96562-58-2

Reaction Conditions

Reference

Preparation of (d)-2-(4-hydroxyphenoxy)propionic acid esters

, Japan, , ,

Production Method 6

96562-58-2

Reaction Conditions

Reference

Preparation of optically active α-(4-hydroxyphenoxy)propionate esters as intermediates for herbicides

, Japan, , ,

Production Method 7

96562-58-2

Reaction Conditions

Reference

Optically active 2-(4-hydroxyphenoxy)propionic acid as herbicide intermediate

, Japan, , ,

Production Method 8

94050-90-5

96562-58-2

Reaction Conditions

1.1 Reagents: Hydrochloric acid Solvents: Methanol

Reference

Preparation of 2-(4-hydroxyphenoxy)propionic acid esters

, European Patent Organization, , ,

Production Method 9

20047-41-0

96562-58-2

Reaction Conditions

1.1 Reagents: Potassium carbonate Solvents: Dimethylformamide ;  8 h, rt → 70 °C

Reference

Preparation of high efficiency flufenoxapyr

, China, , ,

Production Method 10

94050-90-5

96562-58-2

Reaction Conditions

1.1 Catalysts: Dimethyl sulfate ;  4 - 6 h, reflux

Reference

Preparation method of (R)-(+)-methyl 2-(4-hydroxyphenoxy)propanoate

, China, , ,

Production Method 11

2761874-79-5

96562-58-2

Reaction Conditions

1.1 Reagents: Hydrogen Catalysts: Palladium Solvents: Methanol ;  1.0 - 2.0 MPa, rt → 55 °C; 6 h, 45 - 55 °C

Reference

Method for synthesizing R-(+)-2-(4-hydroxyphenoxy) methyl propionate by nucleophilic addition reaction

, China, , ,

Production Method 12

73246-45-4

96562-58-2

Reaction Conditions

1.1 Reagents: Potassium carbonate Solvents: Dimethylformamide ;  80 °C; 3 h, 80 - 90 °C

Reference

Preparation of methyl (R)-(+)-2-(4-hydroxyphenoxy) propionate

, China, , ,

Production Method 13

94050-90-5

96562-58-2

Reaction Conditions

1.1 Catalysts: Tetrachloropalladic acid Solvents: Methanol ,  Toluene ;  2 h, 110 °C

Reference

Method for preparing R-(+)-2-(4-hydroxyphenoxy)propionate

, China, , ,

Production Method 14

94050-90-5

96562-58-2

Reaction Conditions

1.1 Solvents: Methanol ;  65 °C; 5 h, 65 °C

Reference

Asymmetrical synthesis of R-(+)-methyl-2-(4-hydroxyphenoxy)propionate

Qin, Yonghua; Mo, Weimin; Sun, Nan; Wang, Wei, Nongyao, 2004, 43(12), 555-556

Production Method 15

71283-66-4

96562-58-2

Reaction Conditions

1.1 Reagents: Sodium hydroxide Solvents: Methanol ;  40 °C; 24 h, 40 °C
1.2 Reagents: Hydrochloric acid Solvents: Water ;  acidified; 2 h, reflux

Reference

Synthesis and herbicidal activity of new substituted 2- and 4-pyrimidinyloxyphenoxypropionate derivatives

Huang, Tong-Hui; Tu, Hai-Yang; Aibibu, Zumureti; Hou, Chang-Jian; Zhang, Ai-Dong, ARKIVOC (Gainesville, 2011, (2), 1-17

Production Method 16

60075-04-9

96562-58-2

Reaction Conditions

1.1 Reagents: Sodium hydroxide Catalysts: Hydrolase Solvents: Dimethyl sulfoxide ,  Water ;  2 h, pH 7, 30 °C

Reference

Manufacture of R-2-(4-hydroxy phenoxy)propionate with Aspergillus oryzae by resolution

, China, , ,

Production Method 17

109579-04-6

96562-58-2

Reaction Conditions

1.1 Reagents: Potassium carbonate Solvents: Dimethylformamide ;  30 min, 60 - 70 °C
1.2 Solvents: Dimethylformamide ;  60 - 70 °C; 4 h, 60 - 70 °C

Reference

Design and synthesis of quinoxaline derivatives and their antitumor activities

Zhao, Cuihua; Chen, Yi; Ding, Jian; Duan, Wenhu, Yaoxue Xuebao, 2005, 40(9), 814-819

Production Method 18

96562-58-2

Reaction Conditions

Reference

Preparation of 3-fluoro-5-chloropyridinoxyphenoxypropionamide as herbicides

, China, , ,

Production Method 19

96562-58-2

Reaction Conditions

Reference

Preparation of highly-pure 2-(4-hydroxyphenoxy)propionate esters as intermediates for herbicides

, Japan, , ,

Production Method 20

96562-58-2

Reaction Conditions

Reference

Process for the preparation of optically active 2-(4-methoxyphenoxy)propionic acid

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Methyl (R)-(+)-2-(4-Hydroxyphenoxy)propanoate Raw materials

• (-)-Methyl Alpha-Chloropropionate
• methyl (2R)-2-bromopropanoate
• Methyl 2-(4-Hydroxyphenoxy)propionate
• Propanoic acid,2-[[(4-methylphenyl)sulfonyl]oxy]-, methyl ester, (2R)-
• Methyl (2R)-2-[(4-oxo-2,5-cyclohexadien-1-yl)oxy]propanoate
• Propanoic acid, 2-[(methylsulfonyl)oxy]-, methyl ester, (2S)-
• Propanoic acid, 2-[[(4-methylphenyl)sulfonyl]oxy]-, methyl ester, (S)-
• methyl (R)-2-(4-acetoxyphenoxy)propionate
• (R)-(+)-2-(4-Hydroxyphenoxy)propionic Acid

Methyl (R)-(+)-2-(4-Hydroxyphenoxy)propanoate Preparation Products

• Methyl (R)-(+)-2-(4-Hydroxyphenoxy)propanoate (96562-58-2)

• 1. Dissolution of cork biopolymers in biocompatible ionic liquids
  Helga Garcia,Rui Ferreira,Marija Petkovic,Jamie L. Ferguson,Maria C. Leit?o,H. Q. Nimal Gunaratne,Luís Paulo N. Rebelo Green Chem., 2010,12, 367-369
• 2. Evolution in surface coverage of CH3NH3PbI3?XClXvia heat assisted solvent vapour treatment and their effects on photovoltaic performance of devices
  Dhirendra K. Chaudhary,Pramendra Kumar,Lokendra Kumar RSC Adv., 2016,6, 94731-94738
• 3. Enabling shape memory and healable effects in a conjugated polymer by incorporating siloxane via dynamic imine bond?
  Yaling Zhang,Chunhui Dai,Shiwei Zhou,Bin Liu Chem. Commun., 2018,54, 10092-10095
• 4. Dissolved oxygen sensor based on fluorescence quenching of oxygen-sensitive ruthenium complexes immobilized in sol–gel-derived porous silica coatings
  Analyst, 1996,121, 785-788
• 5. Fe(iii)-mediated isomerization of α,α-diarylallylic alcohols to ketones via radical 1,2-aryl migration?
  Ziyang Deng,Changwei Chen,Sunliang Cui RSC Adv., 2016,6, 93753-93755

• Solvents and Organic Chemicals Organic Compounds Acids/Esters

• 60075-04-9(Methyl 2-(4-Hydroxyphenoxy)propionate)
• 115880-50-7(Propanoic acid, 2-phenoxy-, methyl ester, (R)-)
• 5420-69-9(2-phenoxyethyl 2-acetyloxypropanoate)
• 55846-00-9
• 69033-92-7(Propanoic acid, 2-(4-methoxyphenoxy)-, methyl ester)
• 153472-86-7(Propanoic acid,2-(4-phenoxyphenoxy)-, methyl ester)
• 115880-48-3(Propanoic acid, 2-phenoxy-, methyl ester, (S)-)
• 76671-57-3(Propanoic acid, 2-phenoxy-, ethyl ester, (S)-)
• 2065-24-9(Methyl 2-Phenoxypropanoate)
• 790260-09-2(Propanedioic acid, phenoxy-, monomethyl ester)