Production Method 1

96558-73-5

Reaction Conditions

1.1 Reagents: Hydrochloric acid Solvents: Ethanol ,  Water ;  rt → reflux; 5 - 6 h, reflux; reflux → rt
1.2 Solvents: Ethyl acetate ,  Water ;  rt
1.3 Reagents: Sodium hydroxide Solvents: Water ;  neutralized, rt

Reference

Approaches to the Synthesis of 2,3-Dihaloanilines. Useful Precursors of 4-Functionalized-1H-indoles

Guilarte, Veronica; Castroviejo, M. Pilar; Garcia-Garcia, Patricia; Fernandez-Rodriguez, Manuel A.; Sanz, Roberto, Journal of Organic Chemistry, 2011, 76(9), 3416-3437

Production Method 2

19128-48-4

96558-73-5

Reaction Conditions

1.1 Reagents: Hydrazine ,  Iron chloride (FeCl3) Solvents: Methanol ;  80 °C; overnight, 80 °C

Reference

Synthesis of Anthranylaldoxime Derivatives as Estrogen Receptor Ligands and Computational Prediction of Binding Modes

Tuccinardi, Tiziano; Bertini, Simone; Martinelli, Adriano; Minutolo, Filippo; Ortore, Gabriella; et al, Journal of Medicinal Chemistry, 2006, 49(16), 5001-5012

Production Method 3

19128-48-4

96558-73-5

Reaction Conditions

1.1 Reagents: Iron ,  Hydrochloric acid Solvents: Methanol ,  Water ;  2 h, rt → reflux; reflux → rt
1.2 Reagents: Sodium hydroxide Solvents: Water ;  neutralized

Reference

Substituted dihydropyrazinediones as modulators of the NMDA receptor and their preparation

, World Intellectual Property Organization, , ,

Production Method 4

96558-73-5

Reaction Conditions

Reference

Preparation of deactivated anilines

, European Patent Organization, , ,

Production Method 5

1463053-89-5

96558-73-5

Reaction Conditions

1.1 Reagents: Trifluoroacetic acid Solvents: Dichloromethane ;  3 h, rt

Reference

Preparation of cinnolinecarboxamides as BKT inhibitors

, World Intellectual Property Organization, , ,

Production Method 6

56961-26-3

96558-73-5

Reaction Conditions

1.1 Reagents: Triethylamine ,  Diphenylphosphoryl azide Solvents: tert-Butanol ,  Toluene ;  2 h, 80 °C; 18 h, 100 °C

Reference

Preparation of isoindole and isoquinoline dicarboxamides as coagulation factor Xa inhibitors

, World Intellectual Property Organization, , ,

Production Method 7

96558-73-5

Reaction Conditions

Reference

Bromination of 3-haloanilines with 2,4,4,6-tetrabromo-2,5-cyclohexadien-1-one

Markgraf, J. Hodge; Marshall, G. Thomas; Greeley, Michael A., Chemistry & Industry (London, 1987, (8),

Production Method 8

96558-73-5

Reaction Conditions

Reference

Copper(I)-induced bromine-hydrogen exchange of 2,3-dibromoanilines

Liedholm, Brita, Acta Chemica Scandinavica, 1984, 38(10), 877-84

Production Method 9

96558-73-5

21402-26-6

823-57-4

Reaction Conditions

1.1 Reagents: N-Bromosuccinimide Solvents: 1,2-Dichloroethane ;  rt

Reference

Electrophilic bromination of meta-substituted anilines with N-bromosuccinimide: regioselectivity and solvent effect

Bartoli, Sandra; Cipollone, Amalia; Squarcia, Antonella; Madami, Andrea; Fattori, Daniela, Synthesis, 2009, (8), 1305-1308

2-Bromo-3-chloroaniline Raw materials

• Tert-butyl 2-bromo-3-chlorophenylcarbamate
• 2-Bromo-3-chlorobenzoic acid
• 2-Bromo-1-chloro-3-nitrobenzene

2-Bromo-3-chloroaniline Preparation Products

• 4-Bromo-3-chloroaniline (21402-26-6)
• 2-Bromo-5-chloroaniline (823-57-4)
• 2-Bromo-3-chloroaniline (96558-73-5)

• 1. An artificial photosynthetic system for photoaccumulation of two electrons on a fused dipyridophenazine (dppz)–pyridoquinolinone ligand?
  Philipp Traber,Stephan Kupfer,Stefanie Gr?fe,Isabelle Baussanne,Martine Demeunynck,Jean-Marie Mouesca,Serge Gambarelli,Vincent Artero,Murielle Chavarot-Kerlidou Chem. Sci., 2018,9, 4152-4159
• 2. An amphoteric reactivity of a mixed-valent bis(μ-oxo)dimanganese(iii,iv) complex acting as an electrophile and a nucleophile?
  Muniyandi Sankaralingam,So Hyun Jeon,Yong-Min Lee,Mi Sook Seo,Wonwoo Nam Dalton Trans., 2016,45, 376-383
• 3. An apparatus for determining small amounts of alchohol in sour milk and urine
  Analyst, 1964,89, 272-275
• 4. An all-solid-state imprinted polymer-based potentiometric sensor for determination of bisphenol S?
  Rongning Liang,Tanji Yin,Ruiqing Yao,Wei Qin RSC Adv., 2016,6, 73308-73312
• 5. An amino group functionalized metal–organic framework as a luminescent probe for highly selective sensing of Fe3+ ions?
  Zhonghua Xiang,Chuanqi Fang,Sanhua Leng,Dapeng Cao J. Mater. Chem. A, 2014,2, 7662-7665

• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Aniline and substituted anilines 2-bromoanilines
• Solvents and Organic Chemicals Organic Compounds Amines/Sulfonamides

• 873-38-1(2-Bromo-4-chloroaniline)
• 21402-26-6(4-Bromo-3-chloroaniline)
• 89324-52-7(2-Bromo-5-chlorobenzenamine hydrochloride)
• 27761-65-5(2,4-Dibromo-3,6-dichloroaniline)
• 823-57-4(2-Bromo-5-chloroaniline)
• 73-38-1(2-Bromo-4-chloroaniline)
• 823-54-1(3-BROMO-4-CHLOROANILINE)
• 874-17-9(2,6-Dibromo-4-chloroaniline)
• 330809-33-1(Benzenamine, 2-bromo-5-chloro-, hydrobromide (1:1))
• 71642-17-6(Benzenamine, 2,6-dibromo-3,4-dichloro-)