Production Method 1

155988-07-1

96557-30-1

Reaction Conditions

1.1 Reagents: Sodium hydroxide Solvents: Ethanol ;  10 min, 25 °C
1.2 Reagents: Sulfuric acid Solvents: Pentane ,  Water ;  1 h, 0 °C; 0 °C → 25 °C; 3 h, 25 °C

Reference

Total Synthesis of (±)-Armepavines and (±)-Nuciferines From (2-Nitroethenyl)benzene Derivatives

Chang, Chia-Fu; Huang, Chu-Yun; Huang, Yu-Chao; Lin, Kuan-Yu; Lee, Yean-Jang; et al, Synthetic Communications, 2010, 40(23), 3452-3466

Production Method 2

6630-33-7

4525-33-1

96557-30-1

Reaction Conditions

1.1 Reagents: Potassium tert-butoxide Solvents: Tetrahydrofuran
1.2 Reagents: Ammonium chloride
1.3 Solvents: Diethyl ether
1.4 Reagents: Formic acid Solvents: Dichloromethane
1.5 Solvents: Water
1.6 Solvents: Dichloromethane

Reference

A Novel Straightforward Synthesis of Enantiopure Tetrahydroisoquinoline Alkaloids

Pedrosa, Rafael; Andres, Celia; Iglesias, Jesus M., Journal of Organic Chemistry, 2001, 66(1), 243-250

Production Method 3

57486-69-8

96557-30-1

Reaction Conditions

1.1 Reagents: Diisobutylaluminum hydride Solvents: Toluene ;  -78 °C; 2 h, -78 °C
1.2 Solvents: Methanol ;  -78 °C; 1 h, -78 °C; -78 °C → rt; 30 min, rt

Reference

Catalyst for aromatic or vinylic C-O, C-N, and C-C bond formation

, World Intellectual Property Organization, , ,

Production Method 4

96557-30-1

Reaction Conditions

1.1 Reagents: Sodium nitrite ,  Hydrochloric acid Solvents: Acetone ,  Water ;  1.3 min, 0 °C
1.2 Catalysts: Ferrocene Solvents: Acetone ;  8.5 min, 0 °C
1.3 Reagents: Sodium bicarbonate Solvents: Water ;  neutralized, cooled

Reference

Continuous-Flow Synthesis of Monoarylated Acetaldehydes Using Aryldiazonium Salts

Chernyak, Natalia; Buchwald, Stephen L., Journal of the American Chemical Society, 2012, 134(30), 12466-12469

Production Method 5

4009-98-7

6630-33-7

96557-30-1

Reaction Conditions

1.1 Reagents: Potassium tert-butoxide Solvents: Tetrahydrofuran ;  20 min, 0 °C; 45 min, 0 °C
1.2 10 min, 0 °C; 1 h, rt
1.3 Reagents: Hydrochloric acid Solvents: Tetrahydrofuran ;  4 h, reflux

Reference

One-Pot Synthesis of Aminoenone via Direct Reaction of the Chloroalkyl Enone with NaN3 - Rapid Access to Polycyclic Alkaloids

Zhao, Yu-Ming; Gu, Peiming; Tu, Yong-Qiang; Zhang, Hai-Jun; Zhang, Qing-Wei; et al, Journal of Organic Chemistry, 2010, 75(15), 5289-5295

Production Method 6

1074-16-4

96557-30-1

Reaction Conditions

1.1 Reagents: Pyridinium chlorochromate Solvents: Dichloromethane ;  5 h, rt

Reference

Copper(I)-catalyzed asymmetric [3 + 2] cycloaddition of N-ester acylhydrazones and β-trifluoromethyl-α,β-unsaturated ketones

Zhu, Bo; Fan, Huihui; Ding, Yanan; Zhai, Yubing; Wang, Le; et al, Organic Chemistry Frontiers, 2022, 9(20), 5544-5550

Production Method 7

130089-22-4

96557-30-1

Reaction Conditions

Reference

A new method for the preparation of 3-alkoxy- and 3-hydroxy-3,4-dihydro-1H-2-benzopyrans

Wuensch, Bernhard, Archiv der Pharmazie (Weinheim, 1990, 323(8), 493-9

Production Method 8

130089-23-5

96557-30-1

Reaction Conditions

1.1 Solvents: Tetrahydrofuran ,  Water

Reference

Studies on the development of synthetic routes to enediynes

Comanita, Bogdan Mihai, 1997, , 58(10),

Production Method 9

1074-16-4

96557-30-1

Reaction Conditions

1.1 Reagents: Pyridinium chlorochromate Solvents: Dichloromethane ;  15 h, rt

Reference

(Benzofuranyl)aminoalkyl-substituted boronic acid derivatives and their preparation and use for the treatment of viral infections

, World Intellectual Property Organization, , ,

Production Method 10

57486-69-8

96557-30-1

Reaction Conditions

1.1 Reagents: Diisobutylaluminum hydride Solvents: Toluene

Reference

Air stable, sterically hindered ferrocenyl dialkylphosphines for palladium-catalyzed C-C, C-N, and C-O bond-forming cross-couplings

Kataoka, Noriyasu; Shelby, Quinetta; Stambuli, James P.; Hartwig, John F., Journal of Organic Chemistry, 2002, 67(16), 5553-5566

Production Method 11

130089-22-4

96557-30-1

Reaction Conditions

1.1 180 - 250 °C

Reference

Synthesis of 1'-(carbo-t-butoxy) spiro[isochroman-1,4'-piperidinyl]-3-carboxylic acid

Anjaneyulu, K.; Ram, B.; Wagh, P. B.; Zubaidha, Pudukulathan, Chemistry Journal, 2012, 2(3), 111-117

Production Method 12

1074-16-4

96557-30-1

Reaction Conditions

1.1 Reagents: Dess-Martin periodinane Solvents: Dichloromethane ;  overnight, rt

Reference

Preparation of 1,2,3,4-tetrahydro-1,8-naphthyridine derivatives as inhibitors of (alpha-v)(beta-6) integrin

, World Intellectual Property Organization, , ,

Production Method 13

57486-69-8

96557-30-1

Reaction Conditions

1.1 Reagents: Diisobutylaluminum hydride Solvents: Toluene ;  -78 °C; 4 h, -78 °C
1.2 Reagents: Monopotassium monosodium tartrate tetrahydrate Solvents: Water ;  -78 °C → rt; overnight, rt

Reference

Intramolecular Anti-Carbolithiation of Alkynes: Stereo-Directing Effect of Lithium-Coordinating Substituents

Ly, Kim Uyen; Boussonniere, Anne; Castanet, Anne-Sophie, European Journal of Organic Chemistry, 2022, 2022(2),

Production Method 14

4009-98-7

6630-33-7

96557-30-1

Reaction Conditions

1.1 Reagents: Butyllithium Solvents: Tetrahydrofuran ,  Hexane ;  0 °C; 30 min, 0 °C
1.2 0 °C; 24 h, rt
1.3 Reagents: Ammonium chloride Solvents: Water ;  rt
1.4 Reagents: Hydrochloric acid Solvents: Tetrahydrofuran ,  Water ;  2 - 6 h, reflux

Reference

Indoles Synthesized from Amines via Copper Catalysis

Besandre, Ronald; Jaimes, Miguel; May, Jeremy A., Organic Letters, 2013, 15(7), 1666-1669

Production Method 15

1074-16-4

96557-30-1

Reaction Conditions

1.1 Reagents: Dess-Martin periodinane Solvents: Dichloromethane ;  15 min, rt
1.2 1 h, rt

Reference

Facile synthesis of 4,5,6a,7-tetrahydrodibenzo[de,g]chromene heterocycles and their transformation to phenanthrene alkaloids

Kapadia, Nirav; Harding, Wayne, Tetrahedron, 2013, 69(42), 8914-8920

Production Method 16

1074-16-4

96557-30-1

Reaction Conditions

1.1 Solvents: Dichloromethane

Reference

Silicon-terminated Domino-Heck-Reaktions and Enantioselective Syntheses

Raschke, Thomas, 1996, , ,

2-(2-bromophenyl)acetaldehyde Raw materials

• Benzene, 1-bromo-2-(2-methoxyethenyl)-, (E)- (9CI)
• (Methoxy)methyltriphenylphosphonium Chloride
• 2-Bromobenzaldehyde
• Methyl 2-(2-bromophenyl)acetate
• methoxycarbonyl methyl carbonate
• 3-(2-Bromophenyl)oxirane-2-carboxylic acid
• 2-(2-bromophenyl)ethan-1-ol
• Benzene, 1-bromo-2-(2-nitroethyl)-

2-(2-bromophenyl)acetaldehyde Preparation Products

• 2-(2-bromophenyl)acetaldehyde (96557-30-1)

• 1. An aptamer-based keypad lock system?
  Yaqing Liu,Jiangtao Ren,Jing Li,Jiyang Liu,Erkang Wang Chem. Commun., 2012,48, 802-804
• 2. Acetylcholinesterase amperometric detection system based on a cobalt(II) tetraphenylporphyrin-modified electrode
  Analyst, 1996,121, 1123-1126
• 3. An approach towards the synthesis of novel fused nitrogen tricyclic heterocyclic scaffolds via GBB reaction?
  Sandip Gangadhar Balwe,Yeon Tae Jeong Org. Biomol. Chem., 2018,16, 1287-1296
• 4. An Appraisal of pH triggered Bacitracin drug release, through composite hydrogel systems
  RabailGul,MariamMir,MurtazaNAli
• 5. An asymmetric supercapacitor based on controllable WO3 nanorod bundle and alfalfa-derived porous carbon?
  Kanjun Sun,Fengting Hua,Shuzhen Cui,Yanrong Zhu,Hui Peng,Guofu Ma RSC Adv., 2021,11, 37631-37642

• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Phenylacetaldehydes

• 279245-82-8(1-Bromo-2-naphthaleneacetaldehyde)
• 1057670-77-5(2-(2-bromophenyl)propanedial)
• 1806418-95-0(1-(2,6-Dibromophenyl)propan-2-one)
• 1804252-71-8(1-(3-Bromo-4-ethylphenyl)propan-2-one)
• 21906-31-0(1-(2-bromophenyl)propan-2-one)
• 1806380-96-0(1-(4-Bromo-3-ethylphenyl)propan-2-one)
• 1803842-93-4(2-Bromo-5-ethylphenylpropanal)
• 75554-15-3(2-PROPANONE, 1,3-BIS(2-BROMOPHENYL)-)
• 1806351-11-0(1-(2-Bromo-3-ethylphenyl)propan-2-one)
• 636599-17-2(1-(2-bromo-3-methylphenyl)propan-2-one)