Production Method 1

403-20-3

96047-32-4

Reaction Conditions

1.1 Reagents: Trimethyl borate ,  (Dimethyl sulfide)trihydroboron Solvents: Tetrahydrofuran ;  0 °C → rt; overnight, rt; rt → 0 °C
1.2 Solvents: Methanol

Reference

Preparation of quinoline compounds as antibacterial agents and uses thereof

, World Intellectual Property Organization, , ,

Production Method 2

351-54-2

96047-32-4

Reaction Conditions

1.1 Reagents: Sodium borohydride Solvents: Methanol ;  cooled; 60 min, rt

Reference

Design, synthesis and in vitro/vivo anticancer activity of 4-substituted 7-(3-fluoro-4-methoxybenzyl)-7H-pyrrolo[2,3-d]pyrimidines

Tsai, Pei-Yi; Hu, Gong-Siang; Huang, Po-Hsun; Jheng, Huei-Lin; Lan, Chi-Hsuan; et al, Journal of the Chinese Chemical Society (Weinheim, 2021, 68(9), 1761-1770

Production Method 3

369-30-2

96047-32-4

Reaction Conditions

1.1 Reagents: Aluminum chloride ,  Lithium aluminum hydride Solvents: Diethyl ether

Reference

Potential antidepressants: 3-methyl-6-dimethylamino-1,2-diphenylhexan-3-ol and related compounds

Cervena, Irena; Holubek, Jiri; Svatek, Emil; Valchar, Martin; Protiva, Miroslav, Collection of Czechoslovak Chemical Communications, 1987, 52(10), 2564-71

Production Method 4

351-54-2

96047-32-4

Reaction Conditions

Reference

Mechanochemical Palladium-Catalyzed Oxidative Esterification of Alcohols

van Bonn, Pit; Dressler, Daniela; Weitenhagen, Fabian; Bolm, Carsten, ACS Sustainable Chemistry & Engineering, 2022, 10(4), 1361-1366

Production Method 5

351-54-2

96047-32-4

Reaction Conditions

1.1 Reagents: Sodium borohydride Solvents: Methanol ;  2 h, rt

Reference

Synthesis and Biological Evaluation of 1,2,3-triazole tethered Pyrazoline and Chalcone Derivatives

Hussaini, Syed Mohammed Ali; Yedla, Poornachandra; Babu, Korrapati Suresh; Shaik, Thokhir B.; Chityal, Ganesh Kumar; et al, Chemical Biology & Drug Design, 2016, 88(1), 97-109

Production Method 6

351-54-2

96047-32-4

Reaction Conditions

1.1 Reagents: Sodium borohydride Solvents: Methanol ;  2 h, rt

Reference

Anti-tubercular agents. Part 8: synthesis, antibacterial and antitubercular activity of 5-nitrofuran based 1,2,3-triazoles

Kamal, Ahmed; Hussaini, Syed Mohammed Ali; Faazil, Shaikh; Poornachandra, Y.; Narender Reddy, G.; et al, Bioorganic & Medicinal Chemistry Letters, 2013, 23(24), 6842-6846

Production Method 7

351-54-2

96047-32-4

Reaction Conditions

1.1 Reagents: Diisobutylaluminum hydride Solvents: Tetrahydrofuran ;  30 min, 0 °C; 30 min, 0 °C
1.2 Reagents: Hydrochloric acid Solvents: Water ;  15 min

Reference

Preparation of pyridinylaminoalkoxybenzenes and pyridinylalkoxybenzenes as αvβ3 and/or αvβ5 integrin antagonists

, United States, , ,

Production Method 8

403-20-3

96047-32-4

Reaction Conditions

1.1 Reagents: Trimethyl borate ,  (Dimethyl sulfide)trihydroboron Solvents: Tetrahydrofuran ;  0 °C → rt; overnight, rt; rt → 0 °C
1.2 Reagents: Methanol ;  0 °C

Reference

3,5-Dialkoxypyridine analogues of bedaquiline are potent antituberculosis agents with minimal inhibition of the hERG channel

Sutherland, Hamish S.; Tong, Amy S. T.; Choi, Peter J.; Blaser, Adrian ; Conole, Daniel; et al, Bioorganic & Medicinal Chemistry, 2019, 27(7), 1292-1307

Production Method 9

1197231-80-3

96047-32-4

Reaction Conditions

1.1 Reagents: Lithium aluminum hydride Solvents: Tetrahydrofuran ;  30 min, 0 °C; 5 h, rt; rt → 0 °C
1.2 Reagents: Sodium hydroxide Solvents: Diethyl ether ,  Water ;  15 min, 0 °C

Reference

Pharmaceutical compositions containing sulfonamides as transient receptor potential channel 8 (TRPM8) blockers or their prodrugs

, Japan, , ,

Production Method 10

351-54-2

96047-32-4

Reaction Conditions

1.1 Reagents: Sodium borohydride Solvents: Isopropanol ;  12 h, rt
1.2 Reagents: Hydrochloric acid Solvents: Water ;  neutralized

Reference

Stereoselective synthesis of bromine- and fluorine-substituted (S)-tyrosines and N-BOC-protected derivatives

Sagiyan, A. S.; Babayan, E. P.; Geolchanyan, A. V.; Oganesyan, A. M.; Pripadchev, D. A.; et al, Hayastani Kimiakan Handes, 2007, 60(1), 61-72

Production Method 11

351-54-2

96047-32-4

Reaction Conditions

1.1 Reagents: Diisobutylaluminum hydride Solvents: Tetrahydrofuran ;  30 min, 0 °C; 30 min, 0 °C
1.2 Reagents: Hydrochloric acid Solvents: Water ;  15 min

Reference

Preparation of pyridinylaminoalkoxybenzenes and pyridinylalkoxybenzenes as αvβ3 integrin antagonists

, World Intellectual Property Organization, , ,

Production Method 12

351-54-2

96047-32-4

Reaction Conditions

1.1 Reagents: Sodium borohydride Solvents: Ethanol ,  Tetrahydrofuran ;  2 h, 0 °C

Reference

Benzimidazolone derivatives, method of preparation and their use as phosphodiesterase inhibitors

, World Intellectual Property Organization, , ,

Production Method 13

96047-32-4

Reaction Conditions

Reference

Preparation of hydroxyethoxybenzamide derivatives as dopamine D2 receptor blocker and 5-HT4 receptor stimulator

, World Intellectual Property Organization, , ,

Production Method 14

96047-32-4

Reaction Conditions

Reference

Preparation process and effect of pyrimidine-5-carboxamides as cGMP phosphodiesterase inhibitors for circulatory and allergic diseases and sexual dysfunction remedies

, World Intellectual Property Organization, , ,

Production Method 15

96047-32-4

Reaction Conditions

Reference

Preparation of N-(3-fluorobenzyl)heterocyclic derivatives and their use as pesticides.

, European Patent Organization, , ,

Production Method 16

96047-32-4

Reaction Conditions

Reference

Phenol derivatives

, European Patent Organization, , ,

3-Fluoro-4-methoxybenzyl Alcohol Raw materials

• 3-Fluoro-4-methoxybenzaldehyde
• 3-Fluoro-4-methoxybenzoic acid
• Methyl 3-fluoro-4-methoxybenzoate
• 3-Fluoro-4-(trifluoromethoxy)benzoic Acid Ethyl Ester

3-Fluoro-4-methoxybenzyl Alcohol Preparation Products

• 3-Fluoro-4-methoxybenzyl Alcohol (96047-32-4)

• 1. Evolved polymerases facilitate selection of fully 2′-OMe-modified aptamers?
  Zhixia Liu,Tingjian Chen,Floyd E. Romesberg Chem. Sci., 2017,8, 8179-8182
• 2. Fe/Fe3C@C nanoparticles encapsulated in N-doped graphene–CNTs framework as an efficient bifunctional oxygen electrocatalyst for robust rechargeable Zn–air batteries?
  Zhiyan Chen,Nan Wu,Yaobing Wang,Bing Wang,Yingde Wang J. Mater. Chem. A, 2018,6, 516-526
• 3. Empowering microfluidics by micro-3D printing and solution-based mineral coating?
  Hongxia Li,Aikifa Raza,Qiaoyu Ge,Jin-You Lu,TieJun Zhang Soft Matter, 2020,16, 6841-6849
• 4. Emerging investigators series: ultraviolet and free chlorine aqueous-phase advanced oxidation process: kinetic simulations and experimental validation?
  Divya Kamath,Daisuke Minakata Environ. Sci.: Water Res. Technol., 2018,4, 1231-1238
• 5. Distribution characteristics of nitrogen and the related microbial community in the surface sediments of the Songhua River?
  Congyu Li,Wenfu Wang,Haiyan Wang,Guokai Yan,Weiyang Dong,Zhaosheng Chu,Huan Wang,Yang Chang RSC Adv., 2021,11, 26721-26731

• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Benzyl alcohols

• 1017779-35-9(4-Ethoxy-3,5-difluorobenzyl alcohol)
• 128495-45-4((4-Fluoro-3-methoxyphenyl)methanol)
• 368-21-8(1-Benzyloxy-2-fluoro-benzene)
• 706786-41-6(3,5-Difluoro-4-methoxybenzyl alcohol)
• 152434-86-1(1-Benzyloxy-2,4-difluoro-benzene)
• 536974-94-4((4-(Benzyloxy)-3-fluorophenyl)methanol)
• 918629-67-1(Benzenemethanol, 3-fluoro-4-(4-fluorophenoxy)-)
• 147803-47-2(4-(4-Benzyloxyphenyl)-2-fluorophenol)
• 68359-53-5((4-Fluoro-3-phenoxyphenyl)methanol)
• 887585-14-0((3,4-difluoro-5-methoxyphenyl)methanol)