- Practical Synthesis of Structurally Important Spirodiamine TemplatesTang, F.-Y.; Qu, L.-Q.; Xu, Y.; Ma, R.-J.; Chen, Shu-Hui; et al, Synthetic Communications, 2007, 37(21), 3793-3799
Cas no 960294-18-2 (Tert-butyl 1,8-diazaspiro[5.5]undecane-1-carboxylate)
![Tert-butyl 1,8-diazaspiro[5.5]undecane-1-carboxylate structure](https://ossimg.kuujia.com/scimg/960500/960294-18-2x500.png)
960294-18-2 structure
Product Name:Tert-butyl 1,8-diazaspiro[5.5]undecane-1-carboxylate
CAS No:960294-18-2
MF:C14H26N2O2
MW:254.368443965912
MDL:MFCD10700119
CID:832184
PubChem ID:24740465
Update Time:2024-10-25
Tert-butyl 1,8-diazaspiro[5.5]undecane-1-carboxylate Chemical and Physical Properties
Names and Identifiers
-
- tert-Butyl 1,8-diazaspiro[5.5]undecane-1-carboxylate
- : TERT-BUTYL 1,8-DIAZASPIRO[5.5]UNDECANE-1-CARBOXYLATE
- 1,8-DIAZASPIRO[5.5]UNDECANE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
- 1,8-Diazaspiro[5.5]undecane-1-carboxylic acid, 1,1-dimethylethyl ester
- 1-Boc-1,8-diazaspiro[5.5]undecane
- WT1165
- 1,8-Diazaspiro[5.5]undecane-1-carboxylic acidtert-butyl ester
- VPLODDZAJNYXTC-UHFFFAOYSA-N
- DT2156
- FCH1627800
- PB26579
- 1-N-Boc-1,8-diazaspiro[5.5]undecane
- OR312322
- AM804621
- SY025410
- 1,1-Dimethylethyl 1,8-diazaspiro[5.5]undecane-1-carboxylate (ACI)
- Tert-butyl 1,8-diazaspiro[5.5]undecane-1-carboxylate
-
- MDL： MFCD10700119
- Inchi： 1S/C14H26N2O2/c1-13(2,3)18-12(17)16-10-5-4-7-14(16)8-6-9-15-11-14/h15H,4-11H2,1-3H3
- InChI Key： VPLODDZAJNYXTC-UHFFFAOYSA-N
- SMILES： O=C(N1C2(CCCNC2)CCCC1)OC(C)(C)C
Computed Properties
- Exact Mass: 254.19900
- Hydrogen Bond Donor Count: 1
- Hydrogen Bond Acceptor Count: 3
- Heavy Atom Count: 18
- Rotatable Bond Count: 2
- Complexity: 311
- Topological Polar Surface Area: 41.6
Experimental Properties
- Density: 1.05
- Boiling Point: 354 oC
- Flash Point: 168 oC
- PSA: 41.57000
- LogP: 2.79630
Tert-butyl 1,8-diazaspiro[5.5]undecane-1-carboxylate Customs Data
- HS CODE：2933990090
- Customs Data：
China Customs Code:
2933990090Overview:
2933990090. Other heterocyclic compounds containing only nitrogen heteroatoms. VAT:17.0%. Tax refund rate:13.0%. Regulatory conditions:nothing. MFN tariff:6.5%. general tariff:20.0%
Declaration elements:
Product Name, component content, use to, Please indicate the appearance of Urotropine, 6- caprolactam please indicate the appearance, Signing date
Summary:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
Tert-butyl 1,8-diazaspiro[5.5]undecane-1-carboxylate Pricemore >>
| Related Categories | No. | Product Name | Cas No. | Purity | Specification | Price | update time | Inquiry |
|---|---|---|---|---|---|---|---|---|
| SHANG HAI XIAN DING Biotechnology Co., Ltd. | ST-D6014-250mg |
Tert-butyl 1,8-diazaspiro[5.5]undecane-1-carboxylate |
960294-18-2 | 97.0% | 250mg |
2137CNY | 2021-05-07 | |
| SHANG HAI XIAN DING Biotechnology Co., Ltd. | ST-D6014-500mg |
Tert-butyl 1,8-diazaspiro[5.5]undecane-1-carboxylate |
960294-18-2 | 97.0% | 500mg |
4275CNY | 2021-05-07 | |
| SHANG HAI XIAN DING Biotechnology Co., Ltd. | ST-D6014-1g |
Tert-butyl 1,8-diazaspiro[5.5]undecane-1-carboxylate |
960294-18-2 | 97.0% | 1g |
6270CNY | 2021-05-07 | |
| SHANG HAI XIAN DING Biotechnology Co., Ltd. | B-SE592-100mg |
Tert-butyl 1,8-diazaspiro[5.5]undecane-1-carboxylate |
960294-18-2 | 95% | 100mg |
644CNY | 2021-05-07 | |
| SHANG HAI XIAN DING Biotechnology Co., Ltd. | B-SE592-250mg |
Tert-butyl 1,8-diazaspiro[5.5]undecane-1-carboxylate |
960294-18-2 | 95% | 250mg |
1466CNY | 2021-05-07 | |
| Alichem | A289000042-1g |
tert-Butyl 1,8-diazaspiro[5.5]undecane-1-carboxylate |
960294-18-2 | 95% | 1g |
$580.95 | 2023-08-31 | |
| ChemScence | CS-0000448-100mg |
tert-Butyl 1,8-diazaspiro[5.5]undecane-1-carboxylate |
960294-18-2 | 100mg |
$56.0 | 2022-04-26 | ||
| ChemScence | CS-0000448-250mg |
tert-Butyl 1,8-diazaspiro[5.5]undecane-1-carboxylate |
960294-18-2 | 250mg |
$84.0 | 2022-04-26 | ||
| ChemScence | CS-0000448-1g |
tert-Butyl 1,8-diazaspiro[5.5]undecane-1-carboxylate |
960294-18-2 | 1g |
$229.0 | 2022-04-26 | ||
| Chemenu | CM109234-1g |
tert-butyl 1,8-diazaspiro[5.5]undecane-1-carboxylate |
960294-18-2 | 97% | 1g |
$385 | 2021-08-06 |
Tert-butyl 1,8-diazaspiro[5.5]undecane-1-carboxylate Production Method
Production Method 1
Reaction Conditions
1.1 Reagents: Lithium diisopropylamide Solvents: Tetrahydrofuran ; 45 min, -78 °C
1.2 -78 °C; -78 °C → rt; overnight, rt
1.3 Reagents: Ammonium chloride Solvents: Water ; rt
1.4 Reagents: Hydrogen , Ammonium hydroxide Catalysts: Nickel Solvents: Methanol ; 6 h, 50 °C
1.2 -78 °C; -78 °C → rt; overnight, rt
1.3 Reagents: Ammonium chloride Solvents: Water ; rt
1.4 Reagents: Hydrogen , Ammonium hydroxide Catalysts: Nickel Solvents: Methanol ; 6 h, 50 °C
Reference
Production Method 2
Reaction Conditions
Reference
- Azacarbazoles as Btk inhibitors and their preparation, pharmaceutical compositions and use in the treatment of diseases, World Intellectual Property Organization, , ,
Production Method 3
Reaction Conditions
1.1 Reagents: Hydrogen , Ammonium hydroxide Catalysts: Nickel Solvents: Methanol , Water ; 16 h, 35 psi, 45 °C
Reference
- Process for preparation of α-azospiro compounds, China, , ,
Production Method 4
Reaction Conditions
1.1 Reagents: Acetic acid , Ammonium formate Catalysts: Palladium Solvents: Methanol ; 5 h, reflux
Reference
- Design, synthesis, and protein methyltransferase activity of a unique set of constrained amine containing compoundsZhou, Hao ; Che, Xin; Bao, Guochen; Wang, Na; Peng, Li; et al, Bioorganic & Medicinal Chemistry Letters, 2016, 26(18), 4436-4440
Production Method 5
Reaction Conditions
Reference
- Azacarbazoles as Btk inhibitors and their preparation, World Intellectual Property Organization, , ,
Tert-butyl 1,8-diazaspiro[5.5]undecane-1-carboxylate Raw materials
- tert-Butyl 2-(3-chloropropyl)-2-cyanopiperidine-1-carboxylate
- 1,1-Dimethylethyl 8-(phenylmethyl)-1,8-diazaspiro[5.5]undec-3-ene-1-carboxylate
- tert-Butyl 2-(2-chloroethyl)-2-cyanopiperidine-1-carboxylate
Tert-butyl 1,8-diazaspiro[5.5]undecane-1-carboxylate Preparation Products
Tert-butyl 1,8-diazaspiro[5.5]undecane-1-carboxylate Related Literature
-
Xiao Liu,Jun Xu,Yinyun Lv,Wenyu Wu,Weisheng Liu,Yu Tang Dalton Trans., 2013,42, 9840-9846
-
Juan J. Sánchez,Miguel López-Haro,Juan C. Hernández-Garrido,Ginesa Blanco,Miguel A. Cauqui,José M. Rodríguez-Izquierdo,José A. Pérez-Omil,José J. Calvino,María P. Yeste J. Mater. Chem. A, 2019,7, 8993-9003
-
Yang Chen,Di Zhou,Zheyi Meng,Jin Zhai Chem. Commun., 2016,52, 10020-10023
-
Wenjie Zhao,Hua Hou,Yuchun Jin,Zhixiang Zeng,Xuedong Wu,Qunji Xue RSC Adv., 2014,4, 60307-60315
-
Hailing Chen,Lu Yin,Meng Liu,Laibing Wang,Michiya Fujiki,Wei Zhang RSC Adv., 2019,9, 4849-4856
960294-18-2 (Tert-butyl 1,8-diazaspiro[5.5]undecane-1-carboxylate) Related Products
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