Production Method 1

960294-15-9

960294-16-0

Reaction Conditions

1.1 Reagents: Hydrogen ,  Ammonium hydroxide Catalysts: Nickel Solvents: Methanol ,  Water ;  40 psi, 65 °C

Reference

Process for preparation of α-azospiro compounds

, China, , ,

Production Method 2

153749-89-4

960294-16-0

Reaction Conditions

1.1 Reagents: Lithium diisopropylamide Solvents: Tetrahydrofuran ;  45 min, -78 °C
1.2 -78 °C; -78 °C → rt; overnight, rt
1.3 Reagents: Ammonium chloride Solvents: Water ;  rt
1.4 Reagents: Hydrogen ,  Ammonium hydroxide Catalysts: Nickel Solvents: Methanol ;  6 h, 50 °C

Reference

Practical Synthesis of Structurally Important Spirodiamine Templates

Tang, F.-Y.; Qu, L.-Q.; Xu, Y.; Ma, R.-J.; Chen, Shu-Hui; et al, Synthetic Communications, 2007, 37(21), 3793-3799

Production Method 3

960294-15-9

960294-16-0

Reaction Conditions

1.1 Reagents: Lithium aluminum hydride
1.2 Reagents: Ammonia Solvents: Water

Reference

Synthesis of 8-oxa-2-azaspiro[4.5]decane

Ogurtsov, V. A.; Rakitin, O. A., Russian Chemical Bulletin, 2020, 69(10), 2017-2019

tert-butyl 2,6-diazaspiro[4.5]decane-6-carboxylate Raw materials

• tert-Butyl 2-cyanopiperidine-1-carboxylate
• tert-Butyl 2-(2-chloroethyl)-2-cyanopiperidine-1-carboxylate

tert-butyl 2,6-diazaspiro[4.5]decane-6-carboxylate Preparation Products

• tert-butyl 2,6-diazaspiro[4.5]decane-6-carboxylate (960294-16-0)

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• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Azaspirodecane derivatives Azaspirodecane derivatives
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Azaspirodecane derivatives

• 1407522-01-3(tert-butyl 2,6-diazaspiro[4.5]decane-6-carboxylate;hydrochloride)
• 939793-21-2(tert-butyl 1,7-diazaspiro[4.5]decane-7-carboxylate)
• 960294-14-8(Tert-Butyl 1,7-diazaspiro[4.5]decane-1-carboxylate)
• 2323066-69-7(tert-butyl (5S)-1,7-diazaspiro[4.4]nonane-1-carboxylate)
• 159877-36-8(tert-butyl 2,3,4,4a,5,6,7,7a-octahydropyrrolo[3,4-b]pyridine-1-carboxylate)
• 646055-63-2(tert-butyl 1,7-diazaspiro[4.4]nonane-7-carboxylate)
• 1086394-55-9(Tert-butyl 2,6-diazaspiro[4.5]decane-2-carboxylate)
• 885268-47-3(Tert-butyl 1,7-diazaspiro[4,4]nonane-1-carboxylate)
• 1086394-76-4(2,6-Diazaspiro[4.5]decane-6-carboxylic acid, phenylMethyl ester)
• 1058737-47-5(tert-butyl (1R,5S)-3,6-diazabicyclo[3.2.1]octane-6-carboxylate)