Production Method 1

72-18-4

135544-68-2

96-81-1

Reaction Conditions

1.1 Reagents: Sodium bicarbonate Solvents: Acetone ,  Water ;  12 h, rt
1.2 Reagents: Hydrochloric acid Solvents: Water ;  pH 3, rt

Reference

Pyrrolobenzodiazepine antibody conjugates

, World Intellectual Property Organization, , ,

Production Method 2

72-18-4

96-81-1

Reaction Conditions

1.1 Solvents: Acetic acid ;  rt → 70 °C; 1 h, 70 °C; 5 h, 70 °C; 1 h, 70 °C; 0.08 MPa, 60 °C
1.2 Reagents: Water ;  12 h, cooled

Reference

Method for preparing n-acetylamino acid from amino acid, acetic anhydride, and acetic acid

, China, , ,

Production Method 3

72-18-4

96-81-1

Reaction Conditions

1.1 Catalysts: Sulfuric acid Solvents: Acetic anhydride ;  24 h, rt

Reference

Synthesis of Planar Chiral Phosphapalladacycles by N-Acyl Amino Acid Mediated Enantioselective Palladation

Gunay, M. Emin; Richards, Christopher J., Organometallics, 2009, 28(19), 5833-5836

Production Method 4

72-18-4

96-81-1

Reaction Conditions

1.1 Reagents: Sodium hydroxide Solvents: Water

Reference

Stereoselective synthesis of cyclobutanols by Yang photocyclization. Influence of hydrogen bridges on the efficiency and selectivity

Cygon, Peter, 2004, , ,

Production Method 5

72-18-4

96-81-1

Reaction Conditions

1.1 Solvents: Methanol ;  6 h, 70 °C

Reference

Combinatorial ligand design for transition metal catalysts featuring one coordinating and one non-coordinating building block wherein building blocks contain complementary functionalities to promote non-covalent bonding

, European Patent Organization, , ,

Production Method 6

72-18-4

96-81-1

Reaction Conditions

1.1 Reagents: Sodium hydroxide Solvents: Water ;  0 °C; rt
1.2 Reagents: Hydrochloric acid Solvents: Water ;  pH 2 - 3, rt

Reference

Bio- and medicinally compatible α-amino acid modification via merging photo-redox and N-heterocyclic carbene catalysis

Feng, Jie; Zhang, Kuili; Ma, Rui; Gao, Jian; Lu, Tao; et al, ChemRxiv, 2020, , 1-7

Production Method 7

156525-70-1

96-81-1

Reaction Conditions

1.1 Reagents: Hydrogen Catalysts: Palladium Solvents: Ethanol ;  16 h, rt

Reference

Preparation of hexahydro(di)azepino[3,2,1-hi]indole-, tetrahydro-7H-6-oxa-9a-azabenzo[cd]azulene- and tetrahydro-7H-6-thia-9a-azabenzo[cd]azulene-containing peptides as granzyme B directed imaging and therapy

, World Intellectual Property Organization, , ,

Production Method 8

60-35-5

96-81-1

Reaction Conditions

Reference

Preparation of N-acylamino acids from aldehydes, carboxamides, and carbon monoxide

, Federal Republic of Germany, , ,

Production Method 9

96-81-1

Reaction Conditions

Reference

Method for resolving enantiomers from racemic mixture having chiral carbon in alpha position of nitrogen

, World Intellectual Property Organization, , ,

Production Method 10

72-18-4

96-81-1

Reaction Conditions

1.1 Solvents: Water

Reference

Insight into β-hairpin stability: a structural and thermodynamic study of diastereomeric β-hairpin mimetics

Erdelyi, Mate; Langer, Vratislav; Karlen, Anders; Gogoll, Adolf, New Journal of Chemistry, 2002, 26(7), 834-843

Production Method 11

60-35-5

96-81-1

Reaction Conditions

1.1 Catalysts: Triphenylphosphine ,  Lithium bromide ,  Sulfuric acid ,  Di-μ-chlorobis[(1,2,5,6-η)-1,5-cyclooctadiene]diiridium Solvents: N-Methyl-2-pyrrolidone
1.2 -

Reference

Amidocarbonylation procedure and catalysts for the production of N-acylamino acids from the reaction of carbon monoxide with aldehydes and amides or nitriles

, Germany, , ,

Production Method 12

72-18-4

96-81-1

Reaction Conditions

1.1 1 h, 150 °C

Reference

N-acylation of amino acids and amines

, World Intellectual Property Organization, , ,

Production Method 13

72-18-4

96-81-1

Reaction Conditions

1.1 Reagents: Sodium hydroxide Solvents: Water ;  15 min, rt; 1 h, rt

Reference

A facile synthesis and IR-LD spectral elucidation of N-acetyl amino acid derivatives

Chapkanov, A. G.; Dzimbova, T. A.; Ivanova, B. B., Bulgarian Chemical Communications, 2012, 44(3), 228-232

Production Method 14

72-18-4

96-81-1

Reaction Conditions

1.1 Solvents: Methanol ;  6 h, 70 °C

Reference

"Cofactor"-Controlled Enantioselective Catalysis

Dydio, Pawel; Rubay, Christophe; Gadzikwa, Tendai; Lutz, Martin; Reek, Joost N. H., Journal of the American Chemical Society, 2011, 133(43), 17176-17179

Production Method 15

72-18-4

96-81-1

Reaction Conditions

1.1 Reagents: Sodium hydroxide Solvents: Water ;  0 °C; rt
1.2 Reagents: Hydrochloric acid Solvents: Water ;  pH 2 - 3, rt

Reference

Bio- and medicinally compatible α-amino-acid modification via merging photoredox and N-heterocyclic carbene catalysis

Du, Ding ; Zhang, Kuili; Ma, Rui; Chen, Lei; Gao, Jian ; et al, Organic Letters, 2020, 22(16), 6370-6375

Production Method 16

72-18-4

96-81-1

Reaction Conditions

1.1 Solvents: Water ;  4 min, rt

Reference

Antibodies conjugated with antitumor agent through novel peptidomimetic linkers for cancer prevention and therapy

, World Intellectual Property Organization, , ,

Production Method 17

72-18-4

96-81-1

Reaction Conditions

Reference

Palladium-Catalyzed [3 + 2] Annulation of Aromatic Amides with Maleimides through Dual C-H Activation

Naskar, Gouranga; Jeganmohan, Masilamani, Organic Letters, 2023, 25(13), 2190-2195

Production Method 18

72-18-4

96-81-1

Reaction Conditions

Reference

Ligand-Enabled [3+2] Annulation of Aromatic Acids with Maleimides by C(sp3)-H and C(sp2)-H Bond Activation

Naskar, Gouranga; Jeganmohan, Masilamani, Chemistry - A European Journal, 2022, 28(39),

Production Method 19

72-18-4

96-81-1

Reaction Conditions

Reference

Separation and indirect detection of amino acids as acetylated derivatives

Yuan, Dongxing; Pietrzyk, Donald J., Journal of Chromatography, 1991, 557(1-2), 315-24

Production Method 20

96-81-1

Reaction Conditions

Reference

Resolution of 3-aminoalkylnitriles

, World Intellectual Property Organization, , ,

N-Acetyl-L-valine Raw materials

• L-Valine
• N-Acetyl-L-valine phenylmethyl ester
• Aloc-OSu
• Acetamide

N-Acetyl-L-valine Preparation Products

• N-Acetyl-L-valine (96-81-1)

• 1. Alumina grafted SBA-15 sustainable bifunctional catalysts for direct cross-coupling of benzylic alcohols to diarylmethanes?
  Chandran Rajendran,Govindaswamy Satishkumar,Charlotte Lang,Eric M. Gaigneaux Catal. Sci. Technol., 2020,10, 2583-2592
• 2. An anti-ultrasonic-stripping effect in confined micro/nanoscale cavities and its applications for efficient multiscale metallic patterning?
  Quan Xiang,Yiqin Chen,Zhiqin Li,Kaixi Bi,Guanhua Zhang,Huigao Duan Nanoscale, 2016,8, 19541-19550
• 3. Acentric and chiral heterometallic inorganic–organic hybrid frameworks mediated by alkali or alkaline earth ions: synthesis and NLO properties
  Huabin Zhang,Shaowu Du CrystEngComm, 2014,16, 4059-4068
• 4. An asymmetric supercapacitor based on controllable WO3 nanorod bundle and alfalfa-derived porous carbon?
  Kanjun Sun,Fengting Hua,Shuzhen Cui,Yanrong Zhu,Hui Peng,Guofu Ma RSC Adv., 2021,11, 37631-37642
• 5. An alumina stabilized graphene oxide wrapped SnO2 hollow sphere LIB anode with improved lithium storage?
  Xiang Liu,Qian Sun,A. B. Djuri?i?,Maohai Xie,Baohu Dai,Jinyao Tang,Charles Surya,Changzhong Liao,Kaimin Shih RSC Adv., 2015,5, 100783-100789

• Solvents and Organic Chemicals Organic Compounds Organic acids and derivatives Carboxylic acids and derivatives Amino acids, peptides, and analogues Amino acids and derivatives
• Solvents and Organic Chemicals Organic Compounds Acids/Esters

• 102059-44-9(Ethyl,2-[(1-carboxy-2-methylpropyl)amino]-2-oxo- (9CI))
• 17916-88-0(N-Acetyl-D-valine)
• 114285-08-4(Propyl,3-(acetylamino)-3-carboxy-2-methyl- (9CI))
• 22146-58-3(2-Acetamido-3,3-dimethylbutanoic Acid)
• 20051-64-3(N-propanoyl-L-valine)
• 3067-19-4(N-Acetyl-DL-Valine)
• 73465-39-1((2R*,3S*)-N-acetyl-DL-alloisoleucine)
• 93839-03-3((2s)-2-acetamido-3-methylbutanoic Acid;2-(dimethylamino)ethanol)
• 101067-12-3(D-Valine-2-d, N-acetyl- (9CI))
• 22146-59-4((2S)-2-acetamido-3,3-dimethylbutanoic acid)