Production Method 1

27258-33-9

959986-66-4

Reaction Conditions

1.1 Reagents: N-Iodosuccinimide Solvents: Trifluoroacetic acid ;  1.5 h, rt
1.2 Reagents: Water

Reference

Preparation of fused polycyclic 2-pyridinone antibacterial compounds

, World Intellectual Property Organization, , ,

Production Method 2

39806-90-1

959986-66-4

Reaction Conditions

1.1 Reagents: Lithium diisopropylamide Solvents: Tetrahydrofuran ;  -20 °C; 2 h, -20 °C
1.2 overnight, -20 °C → rt
1.3 Reagents: Ammonium chloride Solvents: Water ;  rt

Reference

Rapid Access to Pyrazolo[3,4-c]pyridines via Alkyne Annulation: Limitations of Steric Control in Nickel-Catalyzed Alkyne Insertions

Heller, Stephen T.; Natarajan, Swaminathan R., Organic Letters, 2007, 9(24), 4947-4950

Production Method 3

27258-33-9

959986-66-4

Reaction Conditions

1.1 Reagents: N-Iodosuccinimide Solvents: Trifluoroacetic acid ;  0 °C; 16 h, rt

Reference

Preparation of thieno[3,2-b]pyrrole[3,2-d]pyridazinone derivatives and their use as PKM2 modulators for the treatment of cancer, obesity and diabetes-related disorders

, World Intellectual Property Organization, , ,

Production Method 4

27258-33-9

959986-66-4

Reaction Conditions

1.1 Reagents: N-Iodosuccinimide Solvents: Trifluoroacetic acid ;  1 h, rt

Reference

Preparation of heteroaryl-pyrazole derivatives as group II mGlu receptor antagonists

, World Intellectual Property Organization, , ,

Production Method 5

27258-33-9

959986-66-4

Reaction Conditions

1.1 Reagents: Sodium acetate ,  Iodine chloride Solvents: Acetic acid ;  rt; 4 h, rt

Reference

Preparation of ethynyl-pyrazole derivatives as group II mGlu receptor antagonists

, World Intellectual Property Organization, , ,

4-Iodo-1-Methyl-1H-pyrazole-5-carbaldehyde Raw materials

• 4-iodo-1-methyl-pyrazole
• 1-Methyl-1H-pyrazole-5-carbaldehyde

4-Iodo-1-Methyl-1H-pyrazole-5-carbaldehyde Preparation Products

• 4-Iodo-1-Methyl-1H-pyrazole-5-carbaldehyde (959986-66-4)

• 1. Achieving crystal-induced room temperature phosphorescence and reversible photochromic properties by strong intermolecular interactions?
  Fuming Xiao,Mengzhu Wang,Yunxiang Lei,Wenbo Dai,Yunbing Zhou,Miaochang Liu,Wenxia Gao,Xiaobo Huang,Huayue Wu J. Mater. Chem. C, 2020,8, 17410-17416
• 2. Achieving Efficient Uranium Extraction by In-situ Ultrasonic Texturization of Commercial Fe Powder
  BomingZhu,HongweiWu,JieKang,XiaofangYu,TaoChen,RuCheng,GuolinYang,WencaiBai,WenkunZhu,RongHe
• 3. Aggregation-induced emission based on a fluorinated macrocycle: visualizing spontaneous and ultrafast solid-state molecular motions at room temperature via F?F interactions?
  Mei Zhang,Jingjing Guo,Tingting Liu,Zhanyu He,Majeed Irfan,Zujin Zhao,Zhuo Zeng J. Mater. Chem. C, 2020,8, 14919-14924
• 4. An approach to C–N activation: coupling of arenesulfonyl hydrazides and arenesulfonyl chlorides with tert-amines via a metal-, oxidant- and halogen-free anodic oxidation??
  M. Sheykhan,S. Khani,S. Shaabanzadeh,M. Joafshan Green Chem., 2017,19, 5940-5948
• 5. An antioxidative galactomannan extracted from Chinese Sesbania cannabina enhances immune activation of macrophage cells?
  Chongyang Zhu,Xiaojia Bian,Xin Jia,Ning Tang,Yongqiang Cheng Food Funct., 2020,11, 10635-10644

• Solvents and Organic Chemicals Organic Compounds Organic oxygen compounds Organooxygen compounds Carbonyl compounds Aldehydes

• 1354704-21-4(1-(4-Iodo-2-methyl-2H-pyrazol-3-yl)-ethanone)
• 1214997-78-0(4-Iodo-1-methyl-1H-pyrazole-3-carbaldehyde)
• 6647-96-7(4-iodo-1,5-dimethyl-1H-pyrazole)
• 67208-10-0(4-iodo-1,3-dimethyl-1H-pyrazole-5-carboxylic acid)
• 292855-29-9(4-Iodo-2-methyl-2H-pyrazole-3-carboxylic acid amide)
• 75092-30-7(4-Iodo-1-methyl-1H-pyrazole-5-carboxylic acid)
• 27258-33-9(1-Methyl-1H-pyrazole-5-carbaldehyde)
• 51660-65-2(4-Iodo-1,3,5-trimethyl-1H-pyrazole)
• 2054953-22-7(1-ethyl-4-iodo-1H-pyrazole-3-carbaldehyde)
• 6647-95-6(4-IODO-1,5-DIMETHYL-1H-PYRAZOLE-3-CARBOXYLIC ACID)