Production Method 1

95933-72-5

Reaction Conditions

Reference

Methods for treating or preventing neuroinflammation or autoimmune disease with the use of ribonucleotide reductase inhibitors

, Canada, , ,

Production Method 2

95933-72-5

Reaction Conditions

Reference

Benzamidoximes for treatment of diseases involving excess free-radical formation

, United States, , ,

Production Method 3

17345-61-8

95933-72-5

Reaction Conditions

1.1 Reagents: Sodium hydroxide ,  Hydroxylamine, monohydrate Solvents: Ethanol ,  Water ;  18 h, reflux

Reference

Activity of coumarin-oxadiazole-appended phenol in inhibiting DNA oxidation and scavenging radical

Gong, Xiao-Rui; Xi, Gao-Lei; Liu, Zai-Qun, Tetrahedron Letters, 2015, 56(45), 6257-6261

Production Method 4

17345-61-8

95933-72-5

Reaction Conditions

1.1 Reagents: Sodium hydroxide ,  Hydroxylamine, sulfate Solvents: Water ;  pH 8
1.2 18 h, 45 °C

Reference

Methods using ribonucleotide reductase inhibitors for treating or preventing neuroinflammatory or autoimmune diseases

, United States, , ,

Production Method 5

17345-61-8

95933-72-5

Reaction Conditions

1.1 Reagents: Hydroxylamine

Reference

Polyhydroxybenzoic acid derivatives

, World Intellectual Property Organization, , ,

N',3,4-trihydroxybenzene-1-carboximidamide Raw materials

• 3,4-Dihydroxybenzonitrile

N',3,4-trihydroxybenzene-1-carboximidamide Preparation Products

• N',3,4-trihydroxybenzene-1-carboximidamide (95933-72-5)

• 1. Elusive 2-aminofuran Diels–Alder substrates for a straightforward synthesis of polysubstituted anilines?
  Ana G. Neo,Ana Bornadiego,Jesús Díaz,Stefano Marcaccini,Carlos F. Marcos Org. Biomol. Chem., 2013,11, 6546-6555
• 2. Fe/Fe3C@C nanoparticles encapsulated in N-doped graphene–CNTs framework as an efficient bifunctional oxygen electrocatalyst for robust rechargeable Zn–air batteries?
  Zhiyan Chen,Nan Wu,Yaobing Wang,Bing Wang,Yingde Wang J. Mater. Chem. A, 2018,6, 516-526
• 3. Evolved polymerases facilitate selection of fully 2′-OMe-modified aptamers?
  Zhixia Liu,Tingjian Chen,Floyd E. Romesberg Chem. Sci., 2017,8, 8179-8182
• 4. Emulsion soft templating of carbide-derived carbon nanospheres with controllable porosity for capacitive electrochemical energy storage?
  M. Zeiger,N. J?ckel,P. Strubel,L. Borchardt,R. Reinhold,W. Nickel,J. Eckert,V. Presser,S. Kaskel J. Mater. Chem. A, 2015,3, 17983-17990
• 5. Fate of nitrogen-15 in the subsequent growing season of greenhouse tomato plants (Lycopersicon esculentum Mill) as influenced by alternate partial root-zone irrigation
  Maomao Hou,Fenglin Zhong,Qiu Jin,Enjiang Liu,Jie Feng,Tengyun Wang,Yue Gao RSC Adv., 2017,7, 34392-34400

• Solvents and Organic Chemicals Organic Compounds Benzenoids Phenols Benzenediols Catechols
• Solvents and Organic Chemicals Organic Compounds Benzenoids Phenols Catechols

Introduction to N'^',3,4-trihydroxybenzene-1-carboximidamide (CAS No. 95933-72-5)

N'^',3,4-trihydroxybenzene-1-carboximidamide is a specialized organic compound that has garnered significant attention in the field of chemical biology and pharmaceutical research. This compound, identified by its CAS number 95933-72-5, is characterized by its unique structural features and potential applications in various biochemical pathways. The presence of multiple hydroxyl groups and the carboximidamide functional group makes it a versatile molecule for synthetic chemistry and drug development.

The molecular structure of N',3,4-trihydroxybenzene-1-carboximidamide consists of a benzene ring substituted with three hydroxyl groups at the 3, 4, and 1 positions, respectively, along with a carboximidamide moiety attached to the nitrogen atom. This configuration imparts distinct electronic and steric properties to the molecule, making it an attractive candidate for further investigation in medicinal chemistry.

In recent years, there has been growing interest in exploring the pharmacological properties of hydroxylated aromatic compounds due to their potential role in modulating various biological processes. The hydroxyl groups in N',3,4-trihydroxybenzene-1-carboximidamide can participate in hydrogen bonding interactions, which are crucial for binding to biological targets such as enzymes and receptors. This feature has led to its investigation as a possible scaffold for developing novel therapeutic agents.

One of the most compelling aspects of this compound is its potential application in the synthesis of bioactive molecules. The carboximidamide group provides a versatile handle for further functionalization, allowing chemists to design derivatives with enhanced biological activity. For instance, researchers have explored its use in creating inhibitors targeting specific enzymes involved in inflammatory pathways. Preliminary studies have suggested that derivatives of N',3,4-trihydroxybenzene-1-carboximidamide may exhibit anti-inflammatory properties by modulating the activity of key enzymes such as cyclooxygenase (COX) and lipoxygenase.

The synthesis of N',3,4-trihydroxybenzene-1-carboximidamide presents an interesting challenge due to the complexity of its structure. However, advances in synthetic methodologies have made it more accessible for research purposes. Modern techniques such as palladium-catalyzed cross-coupling reactions and enzymatic resolutions have enabled the efficient preparation of this compound in multi-step syntheses. These advancements have not only facilitated its study but also opened up new avenues for developing related compounds with tailored properties.

Recent research has also highlighted the importance of understanding the metabolic fate of such compounds. Studies using computational modeling and experimental techniques have provided insights into how N',3,4-trihydroxybenzene-1-carboximidamide might be metabolized in vivo. This information is crucial for predicting its pharmacokinetic behavior and potential side effects. For instance, it has been observed that the hydroxyl groups can undergo oxidation or conjugation with glucuronic acid, which are common metabolic pathways in humans.

The role of this compound in drug discovery has been further underscored by its potential as a lead molecule for kinase inhibitors. Kinases are enzymes that play a critical role in cell signaling pathways and are often implicated in diseases such as cancer. By designing analogs of N',3,4-trihydroxybenzene-1-carboximidamide that target specific kinase domains, researchers aim to develop drugs that can selectively inhibit aberrant signaling pathways without affecting normal cellular processes.

In conclusion, N',3,4-trihydroxybenzene-1-carboximidamide (CAS No. 95933-72-5) represents a promising compound with significant potential in pharmaceutical research. Its unique structural features and biological activities make it an attractive candidate for further exploration. As synthetic methods continue to improve and our understanding of biological pathways deepens, this compound is likely to play an increasingly important role in the development of new therapeutic agents.

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