Production Method 1

4630-80-2

95882-33-0

Reaction Conditions

1.1 Reagents: Sodium hydride Solvents: Tetrahydrofuran ;  reflux; 50 min, reflux; overnight, reflux; reflux → rt

Reference

Preparation of quinazoline derivatives as RAF kinase modulators for treating cancers, inflammations and immune diseases

, World Intellectual Property Organization, , ,

Production Method 2

4630-80-2

95882-33-0

Reaction Conditions

1.1 Reagents: Sodium hydride Solvents: Tetrahydrofuran ;  65 °C; 16 h, 65 °C
1.2 Reagents: Water ;  cooled
1.3 pH 4 - 5

Reference

Preparation of substituted pyrimidines as modulators of MYC family proto-oncogene protein

, World Intellectual Property Organization, , ,

Production Method 3

4524-93-0

95882-33-0

Reaction Conditions

1.1 Reagents: Butyllithium Solvents: Tetrahydrofuran ,  Hexane ;  -78 °C; 1 h, -78 °C
1.2 -78 °C; 1 h, -78 °C; -78 °C → rt
1.3 Reagents: Hydrochloric acid Solvents: Water

Reference

Preparation of pyrazoloquinazolinone and pyrroloquinazolinone derivatives as mGluR2 allosteric modulators useful for treatment of neurological, psychiatric, and other disorders

, World Intellectual Property Organization, , ,

Production Method 4

4630-80-2

95882-33-0

Reaction Conditions

1.1 Reagents: Sodium hydride Solvents: Tetrahydrofuran ;  70 °C; overnight, 70 °C

Reference

Preparation of arylquinoline derivatives as dual FABP inhibitors

, World Intellectual Property Organization, , ,

Production Method 5

5453-85-0

95882-33-0

Reaction Conditions

1.1 Reagents: Sodium hydride Solvents: 1,4-Dioxane ;  30 min, rt
1.2 30 min, rt; 16 h, 105 °C; cooled
1.3 Reagents: Hydrochloric acid Solvents: Water ;  acidified

Reference

Preparation of 7-oxo-4,7-dihydro-pyrazolo[1,5-a]pyrimidine derivatives which are useful in the treatment, amelioration or prevention of a viral disease

, World Intellectual Property Organization, , ,

Production Method 6

5453-85-0

95882-33-0

Reaction Conditions

1.1 Reagents: Sodium hydride Solvents: 1,4-Dioxane ;  30 min, rt
1.2 30 min, rt; 16 h, 105 °C

Reference

Preparation of oxothiazolopyridine carbonic acid derivatives for use as antiviral agents

, World Intellectual Property Organization, , ,

Production Method 7

4630-80-2

95882-33-0

Reaction Conditions

1.1 Reagents: Sodium bis(trimethylsilyl)amide Solvents: Tetrahydrofuran ;  -14.6 °C; 50 min, -14.6 °C; < -3 °C; 10 min, -10 °C; -10 °C → 20 °C; 1 h, 20 °C; overnight, 24 °C; 24 °C → 3 °C
1.2 Reagents: Hydrochloric acid Solvents: Water ;  < 27 °C

Reference

Process for preparing enantiomerically enriched JAK inhibitors

, United States, , ,

Production Method 8

4630-80-2

95882-33-0

Reaction Conditions

1.1 Reagents: Sodium hydride Solvents: Tetrahydrofuran ;  rt → 75 °C; 15 h, 70 °C

Reference

Preparation of Ruxolitinib intermediate

, China, , ,

Production Method 9

5453-85-0

95882-33-0

Reaction Conditions

1.1 Reagents: Sodium hydride Solvents: Tetrahydrofuran ;  overnight, reflux
1.2 Solvents: Water ;  pH 8

Reference

Preparation of pyridine-based compounds as kinase inhibitors useful for treatment of proliferative diseases

, World Intellectual Property Organization, , ,

Production Method 10

5453-85-0

95882-33-0

Reaction Conditions

1.1 Reagents: Sodium hydride Solvents: Tetrahydrofuran ;  rt; overnight, reflux
1.2 Reagents: Hydrogen ion Solvents: Water ;  pH 8

Reference

Preparation of heterocyclic ureas as kinase inhibitors useful for the treatment of proliferative and inflammatory diseases

, World Intellectual Property Organization, , ,

3-Cyclopentyl-3-oxopropanenitrile Raw materials

• Cyclopentanecarbonyl chloride
• Ethyl cyclopentanecarboxylate
• Methyl cyclopentanecarboxylate

3-Cyclopentyl-3-oxopropanenitrile Preparation Products

• 3-Cyclopentyl-3-oxopropanenitrile (95882-33-0)

• 1. Examination of the hydrogen-bonding networks in small water clusters (n = 2–5, 13, 17) using absolutely localized molecular orbital energy decomposition analysis?
  Erika A. Cobar,Paul R. Horn,Robert G. Bergman,Martin Head-Gordon Phys. Chem. Chem. Phys., 2012,14, 15328-15339
• 2. Excimer formation effects and trap-assisted charge recombination loss channels in organic solar cells of perylene diimide dimer acceptors?
  Min Kim,Jae-Joon Lee,Tengling Ye,Panagiotis E. Keivanidis,Kilwon Cho J. Mater. Chem. C, 2020,8, 1686-1696
• 3. Establishment and implications of a characterization method for magnetic nanoparticle using cell tracking velocimetry and magnetic susceptibility modified solutions
  Huading Zhang,Lee R. Moore,Maciej Zborowski,P. Stephen Williams,Shlomo Margel,Jeffrey J. Chalmers Analyst, 2005,130, 514-527
• 4. Emergence of cationic polyamine dendrimersomes: design, stimuli sensitivity and potential biomedical applications
  Partha Laskar,Christine Dufès Nanoscale Adv., 2021,3, 6007-6026
• 5. Fe3O4 nanoclusters highly dispersed on a porous graphene support as an additive for improving the hydrogen storage properties of LiBH4?
  Guang Xu,Wei Zhang,Ying Zhang,Xiaoxia Zhao,Ping Wen,Di Ma RSC Adv., 2018,8, 19353-19361

• Solvents and Organic Chemicals Organic Compounds Organic oxygen compounds Organooxygen compounds Ketones
• Solvents and Organic Chemicals Organic Compounds Organic oxygen compounds Organooxygen compounds Carbonyl compounds Ketones

• 145106-91-8(Cyclopentanecarbonitrile,1-acetyl-2-methyl-, (1R,2R)-rel-)
• 66984-18-7(1-methyl-2-oxocyclopentane-1-carbonitrile)
• 2941-29-9(2-oxocyclopentane-1-carbonitrile)
• 69843-83-0(Cyclopentanecarbonitrile,3-(1-methylethyl)-2-oxo-)
• 128893-49-2(4-(2-oxocyclopentyl)butanenitrile)
• 335421-55-1(Cyclopentanecarbonitrile, 2-oxo-1-(3-oxopentyl)- (9CI))
• 138260-51-2(Cyclopentanone-2-carbonitrile)
• 403615-63-4(Cyclopentanecarbonitrile,1-acetyl-)
• 4594-77-8(3-(2-Oxocyclopentyl)propanenitrile)
• 51004-14-9(2-(2-oxocyclopentyl)acetonitrile)