Production Method 1

2457-47-8

95881-83-7

Reaction Conditions

1.1 Reagents: Potassium hydroxide ;  2 h, rt → 66 °C
1.2 66 °C → 78 °C; 30 h, 78 °C

Reference

Synthesis of 3-methoxy-5-chloro-2,6-dinitropyridine

Chen, Jun; Li, Quan-liang; Wang, Jian-long, Hanneng Cailiao, 2007, 15(5), 500-501

Production Method 2

2457-47-8

95881-83-7

Reaction Conditions

1.1 Reagents: Sodium Solvents: Methanol ;  rt
1.2 Solvents: Dimethyl sulfoxide ;  2 h, 70 °C
1.3 Reagents: Sodium hydroxide Solvents: Water

Reference

New Ligands with Affinity for the α4β2 Subtype of Nicotinic Acetylcholine Receptors. Synthesis, Receptor Binding, and 3D-QSAR Modeling

Audouze, Karine; Oestergaard Nielsen, Elsebet; Olsen, Gunnar M.; Ahring, Philip; Jorgensen, Tino Dyhring; et al, Journal of Medicinal Chemistry, 2006, 49(11), 3159-3171

Production Method 3

2457-47-8

95881-83-7

Reaction Conditions

1.1 Reagents: Potassium hydroxide Solvents: Methanol ;  rt → reflux; 30 h, reflux

Reference

Synthesis of 3-chloro-5-methoxy-2,6-dinitropyridine and determination of its crystal and molecular structures

Chen, Jun; Li, Quan-Liang; Wang, Jian-Long; Geng, Tian-Qi, Youji Huaxue, 2008, 28(1), 123-126

Production Method 4

2457-47-8

95881-83-7

Reaction Conditions

1.1 Solvents: Dimethyl sulfoxide ;  rt; 1 h, 80 °C

Reference

Creating an antibacterial with in vivo efficacy: synthesis and characterization of potent inhibitors of the bacterial cell division protein FtsZ with improved pharmaceutical properties

Haydon, David J.; Bennett, James M.; Brown, David; Collins, Ian; Galbraith, Greta; et al, Journal of Medicinal Chemistry, 2010, 53(10), 3927-3936

Production Method 5

2457-47-8

95881-83-7

Reaction Conditions

1.1 Reagents: Potassium hydroxide Solvents: Methanol ;  30 h, rt → reflux

Reference

Synthesis of 3,5-dimethoxy-2,6-dinitropyridine

Chen, Jun; Li, Quan-liang; Wang, Jian-long; Geng, Tian-qi, Tianjin Huagong, 2007, 21(2), 30-31

Production Method 6

2457-47-8

95881-83-7

Reaction Conditions

Reference

Synthesis of hydroxy-substituted aza-analogs of antitumor anthrapyrazoles

Krapcho, A. Paul; Gallagher, Cynthia E.; Hammach, Abdelhakim; Hacker, Miles P.; Menta, Ernesto; et al, Journal of Heterocyclic Chemistry, 1998, 35(4), 895-906

Production Method 7

2457-47-8

95881-83-7

Reaction Conditions

1.1 Reagents: Sodium methoxide Solvents: Dimethylformamide

Reference

The reactions of some halogenated pyridines with methoxide and methanethiolate ions in dimethylformamide

Testaferri, Lorenzo; Tiecco, Marcello; Tingoli, Marco; Bartoli, Donatella; Massoli, Alberto, Tetrahedron, 1985, 41(7), 1373-84

3-Chloro-5-methoxypyridine Raw materials

• 3,5-Dichloropyridine

3-Chloro-5-methoxypyridine Preparation Products

• 3-Chloro-5-methoxypyridine (95881-83-7)

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