Production Method 1

100366-75-4

95727-86-9

Reaction Conditions

1.1 Reagents: Pyridine ;  2 h, reflux

Reference

Preparation of 3,5-diaryl-1,2,4-oxadiazoles and analogs as activators of caspases and inducers of apoptosis.

, World Intellectual Property Organization, , ,

Production Method 2

31224-82-5

95727-86-9

Reaction Conditions

1.1 Reagents: Hydroxyamine hydrochloride ,  2(1H)-Pyrimidinone, tetrahydro-1,3-dimethyl-, hydrochloride (1:1) Solvents: Acetonitrile ;  3 - 4 h, 60 °C

Reference

HCl·DMPU-assisted one-pot and metal-free conversion of aldehydes to nitriles

Mudshinge, Sagar R.; Potnis, Chinmay S.; Xu, Bo; Hammond, Gerald B., Green Chemistry, 2020, 22(13), 4161-4164

Production Method 3

52334-81-3

95727-86-9

Reaction Conditions

1.1 Catalysts: Tetrakis(triphenylphosphine)palladium Solvents: Dimethylformamide ;  overnight, 80 °C

Reference

Preparation of (tetrahydropyranylamino)cyclopentanecarbonyl-substituted fused azaheterocycles as modulators of cytokine receptors such as CCR2

, World Intellectual Property Organization, , ,

Production Method 4

95727-86-9

Reaction Conditions

Reference

Preparation of benzanilide compounds as pesticides

, Japan, , ,

Production Method 5

95727-86-9

Reaction Conditions

Reference

Preparation of benzanilide derivatives as pesticides

, World Intellectual Property Organization, , ,

Production Method 6

3796-23-4

7677-24-9

95727-86-9

1214383-56-8

Reaction Conditions

1.1 Reagents: Trifluoromethanesulfonic anhydride Solvents: Chloroform ;  rt; 1 h, rt
1.2 3 h, 60 °C; < 60 °C
1.3 Reagents: 4-Methylmorpholine ;  17 h, 60 °C; 60 °C → rt
1.4 Reagents: Sodium bicarbonate Solvents: Water ;  rt

Reference

C-H Cyanation of 6-Ring N-Containing Heteroaromatics

Elbert, Bryony L.; Farley, Alistair J. M.; Gorman, Timothy W.; Johnson, Tarn C.; Genicot, Christophe; et al, Chemistry - A European Journal, 2017, 23(59), 14733-14737

Production Method 7

33252-63-0

95727-86-9

Reaction Conditions

1.1 Reagents: Triethylamine ,  Trifluoromethanesulfonic anhydride Solvents: Dichloromethane ;  rt; 2 h, rt
1.2 Catalysts: Tetrakis(triphenylphosphine)palladium Solvents: Dimethylformamide ;  overnight, 80 °C

Reference

Heteroaromatic ureas as vanilloid receptor (VR1) modulators, in particular antagonists, for treating pain and/or inflammation

, World Intellectual Property Organization, , ,

Production Method 8

52334-81-3

95727-86-9

Reaction Conditions

1.1 Reagents: Polyethylene glycol lauryl ether ,  Poly(methylhydrosiloxane) Catalysts: [2′-(Amino-κN)[1,1′-biphenyl]-2-yl-κC][[5-(diphenylphosphino)-9,9-dimethyl-9H-xa… Solvents: Tetrahydrofuran ,  Water ;  12 h, 65 °C
1.2 Reagents: Sodium bicarbonate Solvents: Water

Reference

Late-stage Pd-catalyzed Cyanations of Aryl/Heteroaryl Halides in Aqueous Micellar Media

Thakore, Ruchita R.; Takale, Balaram S. ; Singhania, Vani; Gallou, Fabrice; Lipshutz, Bruce H., ChemCatChem, 2021, 13(1), 212-216

Production Method 9

50488-42-1

95727-86-9

Reaction Conditions

1.1 Solvents: Dimethyl sulfoxide ;  2 h, 180 °C; cooled

Reference

Preparation of used azabicyclic compounds that inhibit vanilloid receptor subtype 1 (VR1) receptor

, United States, , ,

Production Method 10

50488-42-1

95727-86-9

Reaction Conditions

1.1 Solvents: Dimethyl sulfoxide ;  2 h, 180 °C; cooled

Reference

Preparation of fused azabicyclic compounds that inhibit vanilloid receptor subtype 1 (VR1)

, United States, , ,

Production Method 11

95727-86-9

Reaction Conditions

Reference

Preparation of heterocyclic compounds for treating hepatitis C virus

, World Intellectual Property Organization, , ,

Production Method 12

95727-86-9

Reaction Conditions

Reference

Preparation of phenyl carbamates and their use as agrochemical fungicides and insecticides

, Japan, , ,

Production Method 13

95727-86-9

Reaction Conditions

Reference

Preparation of heterocyclyliminophenyl compounds as agricultural and horticultural fungicides and insecticides

, World Intellectual Property Organization, , ,

5-(trifluoromethyl)pyridine-2-carbonitrile Raw materials

• 2-Iodo-5-(trifluoromethyl)pyridine
• 5-(trifluoromethyl)pyridine-2-carbaldehyde
• 3-(Trifluoromethyl)pyridine
• 2-Bromo-5-(trifluoromethyl)pyridine
• 2-Hydroxy-5-(trifluoromethyl)pyridine
• 2-chloro-5-(trifluoromethyl)pyridine
• trimethylsilanecarbonitrile

5-(trifluoromethyl)pyridine-2-carbonitrile Preparation Products

• 5-(trifluoromethyl)pyridine-2-carbonitrile (95727-86-9)
• 3-(Trifluoromethyl)isonicotinonitrile (1214383-56-8)

• 1. Fe3O4@PANI: a magnetic polyaniline nanomaterial for highly efficient and handy enrichment of intact N-glycopeptides??
  Zhizhen Lai,Mo Zhang,Jinyu Zhou,Tianjing Chen,Dan Li,Xuejing Shen,Jia Liu,Jiang Zhou,Zhili Li Analyst, 2021,146, 4261-4267
• 2. Fe3O4 nanoparticle chains with N-doped carbon coating: magnetotactic bacteria assisted synthesis and high-rate lithium storage?
  Dan Yang,Yanping Zhou,Xianhong Rui,Jixin Zhu,Ziyang Lu,Eileen Fong,Qingyu Yan RSC Adv., 2013,3, 14960-14962
• 3. Evidence of CO2 molecule acting as an electron acceptor on a nanoporous metal–organic-framework MIL-53 or Cr3+(OH)(O2C–C6H4–CO2)?
  Alexandre Vimont,Arnaud Travert,Philippe Bazin,Jean-Claude Lavalley,Marco Daturi,Christian Serre,Gérard Férey,Sandrine Bourrelly,Philip L. Llewellyn Chem. Commun., 2007, 3291-3293
• 4. Exciplex emission from the mixed dimer of naphthalene and 2-cyanonaphthalene in a supersonic jet
  Aloke Das,K. K. Mahato,Chayan K. Nandi,Tapas Chakraborty,Shridhar R. Gadre,Nikhil A. Gokhale Phys. Chem. Chem. Phys., 2002,4, 2162-2168
• 5. Evidence of rutile-to-anatase photo-induced electron transfer in mixed-phase TiO2 by solid-state NMR spectroscopy?
  Weili Dai,Guangjun Wu,Michael Hunger Chem. Commun., 2015,51, 13779-13782

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyridines and derivatives Pyridines and derivatives
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyridines and derivatives

• 329711-41-3(4,5-bis(trifluoromethyl)pyridine-2-carbonitrile)
• 1211540-57-6(5-(difluoromethyl)pyridine-2-carbonitrile)
• 1211583-77-5(3-(difluoromethyl)pyridine-2-carbonitrile)
• 1805001-09-5(2-Cyano-3-(difluoromethyl)-4-(trifluoromethyl)pyridine)
• 1805303-52-9(2-Cyano-4-(difluoromethyl)-3-(trifluoromethyl)pyridine)
• 1805204-21-0(2-Cyano-5-(difluoromethyl)-4-(trifluoromethyl)pyridine)
• 936841-69-9(4-(trifluoromethyl)pyridine-2-carbonitrile)
• 406933-21-9(2-Cyano-3-Trifluoromethylpyridine)
• 143812-63-9(4-(trifluoromethyl)-1H-Pyrrole-2-carbonitrile)
• 1806784-39-3(2-Cyano-5-(difluoromethyl)-3-(trifluoromethyl)pyridine)