Production Method 1

320-31-0

957207-58-8

Reaction Conditions

1.1 Reagents: Hydrochloric acid Solvents: Methanol ;  overnight, reflux

Reference

Preparation of 5-alkynyl-pyrimidines as kinase inhibitors

, World Intellectual Property Organization, , ,

Production Method 2

320-31-0

957207-58-8

Reaction Conditions

1.1 Reagents: Thionyl chloride Solvents: Methanol ;  rt; 12 h, 60 °C

Reference

3-(Pyridin-3-yl)acrylamide and N-(pyridin-3-yl)acrylamide derivatives as PAK and NAMPT modulators and their preparation

, World Intellectual Property Organization, , ,

Production Method 3

191165-13-6

957207-58-8

Reaction Conditions

1.1 Reagents: Sodium hydroxide Solvents: Ethanol ,  Water ;  6 h, reflux
1.2 Reagents: Hydrochloric acid Solvents: Water ;  acidified
1.3 Solvents: Diethyl ether

Reference

Silver-Catalyzed C-H Trifluoromethylation of Arenes Using Trifluoroacetic Acid as the Trifluoromethylating Reagent

Shi, Guangfa; Shao, Changdong; Pan, Shulei; Yu, Jingxun; Zhang, Yanghui, Organic Letters, 2015, 17(1), 38-41

Production Method 4

320-31-0

957207-58-8

Reaction Conditions

1.1 Reagents: Thionyl chloride ;  0 °C; 18 h, reflux

Reference

Preparation of 2-substituted 4,5-dihydroxyisophthalonitriles and their analogs as inhibitors of catechol-O-methyltransferase for the treatment of Parkinson's disease

, World Intellectual Property Organization, , ,

Production Method 5

894796-87-3

957207-58-8

Reaction Conditions

1.1 Reagents: tert-Butyl nitrite ,  Copper bromide (CuBr) Solvents: Acetonitrile ;  1.5 h, reflux

Reference

Preparation of heteroarylamide derivatives as immunosuppressants with S1P agonist activity

, Japan, , ,

Production Method 6

14353-88-9

619-42-1

957207-58-8

107317-58-8

Reaction Conditions

1.1 Catalysts: Tris(2,2′-bipyridine)ruthenium(2+) bis(hexafluorophosphate) Solvents: Acetonitrile ;  12 h, 35 °C

Reference

Visible-Light Photoredox Decarboxylation of Perfluoroarene Iodine(III) Trifluoroacetates for C-H Trifluoromethylation of (Hetero)arenes

Yang, Bin; Yu, Donghai; Xu, Xiu-Hua; Qing, Feng-Ling, ACS Catalysis, 2018, 8(4), 2839-2843

Methyl 4-bromo-2-(trifluoromethyl)benzoate Raw materials

• Bis(trifluoroacetoxy)iodopentafluorobenzene
• 4-BROMO-2-(TRIFLUOROMETHYL)BENZONITRILE
• Methyl 4-amino-2-(trifluoromethyl)benzoate
• 4-Bromo-2-(trifluoromethyl)benzoic acid
• 4-Bromobenzoic Acid Methyl Ester

Methyl 4-bromo-2-(trifluoromethyl)benzoate Preparation Products

• Methyl 4-bromo-3-(trifluoromethyl)benzoate (107317-58-8)
• Methyl 4-bromo-2-(trifluoromethyl)benzoate (957207-58-8)

• 1. Enabling chloride salts for thermal energy storage: implications of salt purity?
  J. Matthew Kurley,Phillip W. Halstenberg,Abbey McAlister,Stephen Raiman,Richard T. Mayes RSC Adv., 2019,9, 25602-25608
• 2. Embedding cyclic nitrone in mesoporous silica particles for EPR spin trapping of superoxide and other radicals?
  Eric Besson,Stéphane Gastaldi,Emily Bloch,Selma Aslan,Hakim Karoui,Olivier Ouari,Micael Hardy Analyst, 2019,144, 4194-4203
• 3. Emerging 2D hybrid nanomaterials: towards enhanced sensitive and selective conductometric gas sensors at room temperature
  Hanie Hashtroudi,Ian D. R. Mackinnon J. Mater. Chem. C, 2020,8, 13108-13126
• 4. Fast-pulsing NMR techniques for the detection of weak interactions: successful natural abundance probe of hydrogen bonds in peptides?
  Amandine Altmayer-Henzien,Valérie Declerck,David J. Aitken,Ewen Lescop,Denis Merlet,Jonathan Farjon Org. Biomol. Chem., 2013,11, 7611-7615
• 5. Fatty acid eutectic mixtures and derivatives from non-edible animal fat as phase change materials?
  Pau Gallart-Sirvent,Marc Martín,Gemma Villorbina,Mercè Balcells,Aran Solé,Luisa F. Cabeza,Ramon Canela-Garayoa RSC Adv., 2017,7, 24133-24139

• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Benzoic acid esters
• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Benzoic acids and derivatives Benzoic acid esters

• 1214323-47-3(methyl 3-bromo-2-(trifluoromethyl)benzoate)
• 1266728-50-0(5-Bromo-2-methyl-3-(trifluoromethyl)benzoic acid)
• 842136-32-7(Methyl 5-bromo-2-(trifluoromethyl)benzoate)
• 320-31-0(4-Bromo-2-(trifluoromethyl)benzoic acid)
• 187331-46-0(Methyl 3-bromo-5-(trifluoromethyl)benzoate)
• 1214324-11-4(Methyl 2-bromo-6-(trifluoromethyl)benzoate)
• 210491-38-6(4-Bromo-2,6-bis(trifluoromethyl)benzoic acid)
• 1214378-94-5(Ethyl 4-Bromo-2-(trifluoromethyl)benzoate)
• 1260793-79-0(Methyl 4-bromo-2,5-bis(trifluoromethyl)benzoate)
• 654-97-7(5-Bromo-2-(trifluoromethyl)benzoic Acid)