Production Method 1

404-01-3

956631-90-6

Reaction Conditions

1.1 Reagents: Phosphorus oxychloride Solvents: Dimethylformamide ;  0 - 5 °C; 4 - 16 h, 85 - 90 °C
1.2 Solvents: Water ;  1 h, cooled; overnight, cooled

Reference

Studies on synthesis and antimicrobial activity of quinoline pyrimidine derivatives

Patel, Vivek S.; Patel, Mayank S.; Tailor, Rahul B.; Patel, Divyanshu D.; Paresh, Paresh S., Journal of Applicable Chemistry (Lumami, 2019, 8(4), 1724-1730

Production Method 2

404-01-3

956631-90-6

Reaction Conditions

1.1 Reagents: Phosphorus oxychloride ;  0 - 5 °C; 4 - 16 h, 85 - 90 °C
1.2 Solvents: Water ;  1 h, cooled; overnight, cooled

Reference

Studies on synthesis of quinolinylchalcones as a new class of anti-microbial agents

Patel, Vivek S.; Patel, Mayank S.; Patel, Divyanshu D.; Patel, P. S.; Patel, K. C., International Journal of Advanced Research, 2014, 2(4), 1125-1128

Production Method 3

404-01-3

956631-90-6

Reaction Conditions

1.1 Reagents: Phosphorus oxychloride ;  0 - 5 °C; 4 - 16 h, 85 - 90 °C
1.2 Solvents: Water ;  1 h, 0 °C; overnight, 0 °C

Reference

Synthesis and anti-microbial activity of some pyrimidine derivatives containing quinoline ring

Patel, Vivek S.; Patel, Divyanshu D.; Patel, Mayank S.; Patel, P. S.; Patel, K. C., World Journal of Pharmacy and Pharmaceutical Sciences, 2016, 5(6), 1875-1883

Production Method 4

404-01-3

956631-90-6

Reaction Conditions

1.1 Reagents: Phosphorus oxychloride ;  0 °C; 0 °C → rt; 30 min, rt
1.2 rt; overnight, 75 °C

Reference

Discovery and in Vivo Evaluation of (S)-N-(1-(7-Fluoro-2-(pyridin-2-yl)quinolin-3-yl)ethyl)-9H-purin-6-amine (AMG319) and Related PI3Kδ Inhibitors for Inflammation and Autoimmune Disease

Cushing, Timothy D.; Hao, Xiaolin; Shin, Youngsook; Andrews, Kristin; Brown, Matthew; et al, Journal of Medicinal Chemistry, 2015, 58(1), 480-511

2-Chloro-5,7-difluoroquinoline-3-carbaldehyde Raw materials

• 3',5'-Difluoroacetanilide

2-Chloro-5,7-difluoroquinoline-3-carbaldehyde Preparation Products

• 2-Chloro-5,7-difluoroquinoline-3-carbaldehyde (956631-90-6)

• 1. An autonomous self-optimizing flow machine for the synthesis of pyridine–oxazoline (PyOX) ligands?
  Eric Wimmer,Daniel Cortés-Borda,Solène Brochard,Elvina Barré,Charlotte Truchet,Fran?ois-Xavier Felpin React. Chem. Eng., 2019,4, 1608-1615
• 2. An atom efficient route to N-aryl and N-alkyl pyrrolines by transition metal catalysis?
  Supaporn Sawadjoon,Joseph S. M. Samec Org. Biomol. Chem., 2011,9, 2548-2554
• 3. An amorphous carbon nitride/NiO/CoN-based composite: a highly efficient nonprecious electrode for supercapacitors and the oxygen evolution reaction?
  Huifang Yang,Haoran Guo,Peidong Fan,Xinpan Li,Wenlu Ren,Rui Song Nanoscale, 2020,12, 7024-7034
• 4. An antioxidant self-healing hydrogel for 3D cell cultures?
  Lei Yang,Yuan Zeng,Haibo Wu,Chunwu Zhou,Lei Tao J. Mater. Chem. B, 2020,8, 1383-1388
• 5. An automatic determination of thoria in thoria-urania mixtures
  Analyst, 1966,91, 208-210

• 209909-13-7(2-Chloro-6,7-difluoro-3-quinolinecarboxaldehyde)
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• 749920-54-5(2-chloro-6-fluoro-quinoline-3-carbaldehyde)
• 745830-16-4(2-chloro-7-fluoroquinoline-3-carbaldehyde)
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• 1167542-21-3(2-chloro-7-fluoro-8-methylquinoline-3-carbaldehyde)
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• 108962-82-9(2-chlorobenzo[h]quinoline-3-carbaldehyde)
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