Production Method 1

723280-91-9

956268-36-3

956268-33-0

Reaction Conditions

1.1 Solvents: Diphenyl ether ;  1 h, reflux

Reference

Synthesis of novel halogenated 4(1H)-quinolones by thermolysis of arylaminomethylene-1,3-dioxane-4,6-diones

Rotzoll, Sven; Reinke, Helmut; Fischer, Christine; Langer, Peter, Synthesis, 2009, (1), 69-78

Production Method 2

723280-91-9

956268-36-3

956268-33-0

Reaction Conditions

1.1 900 s, 0.2 mm Hg, 300 °C

Reference

Gas-phase pyrolysis in organic synthesis: rapid green synthesis of 4-quinolinones

Al-Awadi, Nouria A.; Abdelhamid, Ismail Abdelshafy; Al-Etaibi, Alya M.; Elnagdi, Mohamed Hilmy, Synlett, 2007, (14), 2205-2208

Production Method 3

723280-91-9

956268-36-3

956268-33-0

Reaction Conditions

1.1 Solvents: Diphenyl ether ;  1 h, reflux

Reference

Preparation of bicyclic arylamines as apoptosis signal-regulating kinase 1 (ASK1) inhibitor

, World Intellectual Property Organization, , ,

4(1H)-Quinolinone, 5-bromo- Raw materials

• 1,3-Dioxane-4,6-dione, 5-[[(3-bromophenyl)amino]methylene]-2,2-dimethyl-

4(1H)-Quinolinone, 5-bromo- Preparation Products

• 7-Bromoquinolin-4(1H)-one (956268-33-0)
• 4(1H)-Quinolinone, 5-bromo- (956268-36-3)

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