Production Method 1

32064-67-8

75-12-7

98288-51-8

956025-99-3

Reaction Conditions

1.1 Reagents: Sodium hydride Solvents: Tetrahydrofuran ;  0 - 23 °C
1.2 Reagents: Dimethyl sulfate ,  Sodium bicarbonate Solvents: 1,4-Dioxane ,  Water ;  reflux
1.3 Solvents: Ethanol ;  reflux
1.4 180 °C

Reference

A small molecule inhibitor selective for a variant ATP-binding site of the chaperonin GroEL

Chapman, Eli; Farr, George W.; Furtak, Krystyna; Horwich, Arthur L., Bioorganic & Medicinal Chemistry Letters, 2009, 19(3), 811-813

Production Method 2

1428640-42-9

75-12-7

956025-99-3

Reaction Conditions

1.1 overnight, 150 °C

Reference

Discovery of a potent protein kinase D inhibitor: insights in the binding mode of pyrazolo[3,4-d]pyrimidine analogues

Verschueren, Klaas; Cobbaut, Mathias; Demaerel, Joachim; Saadah, Lina; Voet, Arnout R. D.; et al, MedChemComm, 2017, 8(3), 640-646

Production Method 3

1428640-42-9

75-12-7

956025-99-3

Reaction Conditions

1.1 8 h, 160 - 180 °C

Reference

Optimizing Small Molecule Inhibitors of Calcium-Dependent Protein Kinase 1 to Prevent Infection by Toxoplasma gondii

Lourido, Sebastian; Zhang, Chao; Lopez, Michael S.; Tang, Keliang; Barks, Jennifer; et al, Journal of Medicinal Chemistry, 2013, 56(7), 3068-3077

Production Method 4

7400-27-3

75-12-7

1878-67-7

956025-99-3

Reaction Conditions

1.1 Reagents: Thionyl chloride
1.2 -
1.3 Reagents: Trimethylsilyldiazomethane
1.4 -
1.5 -

Reference

Preparation of pyrazolopyrimidinamines as modulators of protein trafficking

, World Intellectual Property Organization, , ,

Production Method 5

956025-99-3

Reaction Conditions

Reference

Aminopyrazolopyrimidines and related compounds useful for inhibition of alpha-synuclein toxicity and their preparation

, World Intellectual Property Organization, , ,

3BrB-PP1 Raw materials

• Tert-Butylhydrazine hydrochloride
• Tert-butylhydrazine
• 5-Amino-1-tert-butyl-3-(3-bromobenzyl)-1H-pyrazole-4-carbonitrile
• Formamide
• 3-Bromophenylacetic acid
• 3-Bromophenylacetyl Chloride

3BrB-PP1 Preparation Products

• 3BrB-PP1 (956025-99-3)

• 1. Establishing plasmon contribution to chemical reactions: alkoxyamines as a thermal probe?
  Olga Guselnikova,Gérard Audran,Jean-Patrick Joly,Andrii Trelin,Evgeny V. Tretyakov,Vaclav Svorcik,Oleksiy Lyutakov,Sylvain R. A. Marque Chem. Sci., 2021,12, 4154-4161
• 2. Fe(ii)-Assisted one-pot synthesis of ultra-small core–shell Au–Pt nanoparticles as superior catalysts towards the HER and ORR?
  Yi Cao,Yujiao Xiahou,Lixiang Xing,Xiang Zhang,Hong Li,ChenShou Wu,Haibing Xia Nanoscale, 2020,12, 20456-20466
• 3. Enabling shape memory and healable effects in a conjugated polymer by incorporating siloxane via dynamic imine bond?
  Yaling Zhang,Chunhui Dai,Shiwei Zhou,Bin Liu Chem. Commun., 2018,54, 10092-10095
• 4. Fast synthesis of copper nanoclusters through the use of hydrogen peroxide additive and their application for the fluorescence detection of Hg2+ in water samples?
  Liao Xiaoqing,Li Ruiyi,Li Zaijun,Sun Xiulan,Wang Zhouping,Liu Junkang New J. Chem., 2015,39, 5240-5248
• 5. Evidence for the intrinsic nature of band-gap states electrochemically observed on atomically flat TiO2(110) surfaces?
  Shintaro Takata,Yoshihiro Miura Phys. Chem. Chem. Phys., 2014,16, 24784-24789

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyrazolopyrimidines Pyrazolo[3,4-d]pyrimidines

• 158001-19-5(1H-Pyrazolo[3,4-d]pyrimidin-4-amine,1-(1,1-dimethylethyl)-3-(phenylmethyl)-6-(4-pyridinyl)-)
• 956026-24-7(4-Amino-1-tert-butyl-3-(2,3-dimethylbenzyl)pyrazolo3,4-dpyrimidine)
• 1246816-12-5(4-Amino-1-tert-butyl-3-(3-ethyl)pyrazolo3,4-dpyrimidine)
• 221244-14-0(4-Amino-1-tert-butyl-3-(1’-naphthylmethyl)pyrazolo3,4-dpyrimidine)
• 833481-71-3(Phenol, 4-[[4-amino-1-(1,1-dimethylethyl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl]methyl]-)
• 833481-68-8(Phenol, 3-[[4-amino-1-(1,1-dimethylethyl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl]methyl]-)
• 172889-26-8(PP1)
• 956025-83-5(3MB-PP1)
• 833481-73-5(2OH-Bnpp1)
• 186895-85-2(4-Amino-1-tert-butyl-3-benzylpyrazolo3,4-dpyrimidine)