Production Method 1

67589-21-3

95539-61-0

Reaction Conditions

1.1 Reagents: Ammonium formate Catalysts: Palladium Solvents: Ethanol ;  1 h, rt

Reference

New phenylaniline derivatives as modulators of amyloid protein precursor metabolism

Gay, Marion; Carato, Pascal ; Coevoet, Mathilde; Renault, Nicolas; Larchanche, Paul-Emmanuel; et al, Bioorganic & Medicinal Chemistry, 2018, 26(8), 2151-2164

Production Method 2

95539-61-0

Reaction Conditions

1.1 Reagents: Tin ,  Hydrochloric acid Solvents: Water

Reference

Nitrobenzyl derivatives as bioreductive alkylating agents: evidence for the reductive formation of a reactive intermediate

Kirkpatrick, D. L.; Johnson, K. E.; Sartorelli, A. C., Journal of Medicinal Chemistry, 1986, 29(10), 2048-52

Production Method 3

3958-60-9

95539-61-0

Reaction Conditions

1.1 Solvents: Tetrahydrofuran ;  overnight, rt → reflux
1.2 Reagents: Hydrogen Catalysts: Palladium Solvents: Methanol ;  overnight, rt

Reference

Preparation of 3,4-diaminocyclobutene-1,2-diones as CXC chemokine receptor antagonists

, United States, , ,

Production Method 4

3958-60-9

95539-61-0

Reaction Conditions

1.1 Reagents: Potassium carbonate Solvents: Ethanol ;  4 h, 100 °C
1.2 Reagents: Hydrazine hydrate (1:1) Catalysts: Nickel Solvents: Water ;  20 min, 40 °C

Reference

Activity of 2,6,9-trisubstituted purines as potent PDGFRα kinase inhibitors with antileukaemic activity

Reznickova, Eva; Gucky, Tomas; Kovacova, Veronika; Ajani, Haresh; Jorda, Radek ; et al, European Journal of Medicinal Chemistry, 2019, 182,

Production Method 5

95539-61-0

Reaction Conditions

Reference

Preparation of 3-(ureido)-1,4-benzodiazepin-2-one cholecystokinin and gastrin receptor antagonists

, United States, , ,

Production Method 6

95539-61-0

Reaction Conditions

Reference

Preparation of [(heterocyclyl)(alkyl)]phenyl amidines and guanidines as hypoglycemics.

, China, , ,

Production Method 7

95539-61-0

Reaction Conditions

Reference

Cleavage of phthalimides to amines

, United States, , ,

2-[(morpholin-4-yl)methyl]aniline Raw materials

• 1-(bromomethyl)-2-nitrobenzene
• 4-(2-Nitrobenzyl)morpholine

2-[(morpholin-4-yl)methyl]aniline Preparation Products

• 2-[(morpholin-4-yl)methyl]aniline (95539-61-0)

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• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Phenylmethylamines

• 51013-67-3(4-[(morpholin-4-yl)methyl]aniline)
• 620115-15-3(Benzenamine, 4-(1,4,7,10-tetraoxa-13-azacyclopentadec-13-ylmethyl)-)
• 350481-18-4(1,4-Benzenediamine, 2-[[[2-(4-morpholinyl)ethyl]amino]methyl]-,hydrochloride)
• 882873-11-2(4-[(morpholin-4-yl)methyl]aniline dihydrochloride)
• 871217-44-6(methyl({[2-(morpholin-4-yl)phenyl]methyl})amine)
• 937659-58-0(N-Methyl-2-(4-morpholinylmethyl)benzenamine)
• 123207-48-7(3-(Morpholinomethyl)aniline)
• 105488-59-3(Benzenamine,2,2'-[1,4,10-trioxa-7,13-diazacyclopentadecane-7,13-diylbis(methylene)]bis-)
• 81054-21-9(N,N-dimethyl-2,4-bis(morpholin-4-ylmethyl)aniline)
• 350481-10-6(1,4-Benzenediamine, 2-[[(2-methoxyethyl)amino]methyl]-, hydrochloride)