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• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Diazines Pyridinylpyrimidines
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Diazines Pyrimidines and pyrimidine derivatives Pyridinylpyrimidines

2-(Pyridin-2-yl)pyrimidine-5-carbaldehyde: A Comprehensive Overview

The compound 2-(Pyridin-2-yl)pyrimidine-5-carbaldehyde (CAS No. 954226-94-9) is a structurally unique organic compound with significant potential in the fields of medicinal chemistry and materials science. This compound, characterized by its pyridine and pyrimidine moieties, has garnered attention due to its versatile reactivity and promising applications in drug design. Recent studies have highlighted its role in the development of novel therapeutic agents, particularly in the realm of anticancer and anti-inflammatory therapies.

The molecular structure of 2-(Pyridin-2-yl)pyrimidine-5-carbaldehyde consists of a pyrimidine ring fused with a pyridine ring, with an aldehyde group attached at the 5-position. This arrangement imparts the compound with distinct electronic properties, making it an attractive candidate for various chemical transformations. Researchers have explored its ability to undergo nucleophilic addition reactions, which are pivotal in synthesizing bioactive molecules. The presence of electron-withdrawing groups, such as the aldehyde moiety, enhances the reactivity of the compound, facilitating its use in complex molecular constructions.

Recent advancements in synthetic methodologies have further expanded the utility of CAS No. 954226-94-9. For instance, its application in click chemistry has been documented, where it serves as a key intermediate in the synthesis of macrocyclic compounds. These macrocycles hold potential as scaffolds for drug delivery systems due to their ability to encapsulate bioactive molecules and release them in a controlled manner. Additionally, the compound's role in transition metal-catalyzed reactions has been explored, showcasing its versatility in asymmetric synthesis.

In terms of biological activity, 2-(Pyridin-2-yl)pyrimidine-5-carbaldehyde has demonstrated promising results in preclinical studies. It has been evaluated for its anti-proliferative effects against various cancer cell lines, with notable activity observed against breast and colon cancer cells. The compound's ability to modulate key signaling pathways involved in cancer progression suggests its potential as a lead molecule for anticancer drug development. Furthermore, studies have indicated its anti-inflammatory properties, attributed to its inhibitory effects on cyclooxygenase (COX) enzymes.

The synthesis of CAS No. 954226-94-9 involves a multi-step process that typically begins with the preparation of pyridine derivatives followed by their coupling with pyrimidine precursors. Recent optimizations have focused on enhancing yield and purity through the use of microwave-assisted synthesis and continuous flow reactors. These advancements not only improve the efficiency of production but also align with green chemistry principles by minimizing waste and energy consumption.

From a materials science perspective, 2-(Pyridin-2-yl)pyrimidine-5-carbaldehyde has been investigated for its potential as a building block in supramolecular chemistry. Its ability to form hydrogen bonds and π–π interactions makes it suitable for constructing self-assembled monolayers and nanoscale architectures. Such applications could pave the way for innovative materials with tailored properties for use in electronics and sensors.

In conclusion, CAS No. 954226-94-9, or 2-(Pyridin-2-yl)pyrimidine-5-carbaldehyde, stands out as a versatile compound with multifaceted applications across diverse scientific domains. Its structural features, reactivity, and biological activity position it as a valuable tool in both academic research and industrial development. As ongoing studies continue to uncover new dimensions of its utility, this compound is poised to make significant contributions to the advancement of modern science.

• 954227-09-9(2-pyridin-4-ylpyrimidine-5-carbaldehyde)
• 1447607-92-2(2-(5-Methylpyridin-2-YL)pyrimidine-5-carboxylic acid)
• 1068976-90-8(5-Pyrimidinecarboxylic acid, 2-(2-pyridinyl)-, methyl ester)
• 954226-97-2((2-pyridin-2-ylpyrimidin-5-yl)methanol)
• 10198-79-5(5-Methyl-2-(pyridin-2-yl)pyrimidine)
• 1609395-97-2(2-(2-pyridinyl)-5-pyrimidinecarboxylic acid hydrate)
• 1346687-31-7(5-(pyrimidin-2-yl)pyridine-3-carbaldehyde)
• 1068976-76-0(2-(2-pyridinyl)-5-pyrimidinecarbonyl chloride)
• 954227-03-3(2-(pyridin-3-yl)pyrimidine-5-carbaldehyde)
• 933988-22-8(2-(Pyridin-2-yl)pyrimidine-5-carboxylic acid)