Production Method 1

851386-35-1

953780-40-0

Reaction Conditions

1.1 Reagents: Triethylamine Catalysts: Tetrakis(triphenylphosphine)palladium Solvents: Methanol ;  overnight, 0.3 MPa, 65 °C; 65 °C → rt

Reference

Pyridyl amide derivatives, processes for preparing them, pharmaceutical compositions containing them, and their use as T-type calcium channel antagonists

, World Intellectual Property Organization, , ,

Production Method 2

124432-70-8

953780-40-0

Reaction Conditions

1.1 Reagents: Triethylamine Catalysts: Dichloro[1,1′-bis(diphenylphosphino)ferrocene]palladium(II) dichloromethane addu… ,  BINAP Solvents: Methanol ;  20 h, 120 psi, 120 °C

Reference

Preparation of heteroaryl substituted heterocyclyl sulfones as voltage gated calcium channel blockers

, United States, , ,

Production Method 3

959616-64-9

953780-40-0

Reaction Conditions

1.1 Reagents: Formic acid ,  Triethylamine Catalysts: Tetrakis(triphenylphosphine)palladium Solvents: Dimethylformamide ;  rt → 100 °C; 4 h, 100 °C

Reference

Preparation of 1,4,6-triaza-1H-indene compounds as colony stimulating factor 1 receptor modulators

, World Intellectual Property Organization, , ,

Production Method 4

89402-44-8

953780-40-0

Reaction Conditions

1.1 Reagents: Triethylamine Catalysts: Palladium diacetate ,  1,1′-(9,9-Dimethyl-9H-xanthene-4,5-diyl)bis[1,1-diphenylphosphine] ;  1 min, rt; 17 h, 65 °C

Reference

Preparation of 5-fluoronicotinamide derivatives as selective HDAC6 inhibitors for treating heart diseases

, World Intellectual Property Organization, , ,

Production Method 5

959616-64-9

953780-40-0

Reaction Conditions

1.1 Reagents: Formic acid ,  Triethylamine Catalysts: Tetrakis(triphenylphosphine)palladium Solvents: Dimethylformamide ;  rt; 1 h, 50 - 60 °C; 140 min, 90 - 100 °C; rt; 1 h, 90 - 100 °C; 100 °C → rt
1.2 Reagents: Hydrochloric acid Solvents: Ethyl acetate ,  Water ;  pH 4.8

Reference

Preparation of naphthyridinones and related compounds as antibacterial agents

, Japan, , ,

Methyl 5-fluoro-6-methoxynicotinate Raw materials

• 5-bromo-3-fluoro-2-methoxy-pyridine
• 2,3-Difluoro-5-iodopyridine
• 5-Bromo-2,3-difluoropyridine
• methyl 2-chloro-5-fluoro-6-methoxypyridine-3-carboxylate

Methyl 5-fluoro-6-methoxynicotinate Preparation Products

• Methyl 5-fluoro-6-methoxynicotinate (953780-40-0)

• 1. Evolution of cellulose into flexible conductive green electronics: a smart strategy to fabricate sustainable electrodes for supercapacitors
  Tengfei Yu,Yuehan Wu,Wei Li,Bin Li RSC Adv., 2014,4, 34134-34143
• 2. Establishment and implications of a characterization method for magnetic nanoparticle using cell tracking velocimetry and magnetic susceptibility modified solutions
  Huading Zhang,Lee R. Moore,Maciej Zborowski,P. Stephen Williams,Shlomo Margel,Jeffrey J. Chalmers Analyst, 2005,130, 514-527
• 3. Emerging investigator series: heterogeneous reactions of sulfur dioxide on mineral dust nanoparticles: from single component to mixed components?
  Tao Wang,Yangyang Liu,Yue Deng,Hongbo Fu,Jianmin Chen Environ. Sci.: Nano, 2018,5, 1821-1833
• 4. Exciplex emission from the mixed dimer of naphthalene and 2-cyanonaphthalene in a supersonic jet
  Aloke Das,K. K. Mahato,Chayan K. Nandi,Tapas Chakraborty,Shridhar R. Gadre,Nikhil A. Gokhale Phys. Chem. Chem. Phys., 2002,4, 2162-2168
• 5. EWOD-driven droplet microfluidic device integrated with optoelectronic tweezers as an automated platform for cellular isolation and analysis?
  Gaurav J. Shah,Eric P.-Y. Chiou,Ming C. Wu,Chang-Jin “CJ” Kim Lab Chip, 2009,9, 1732-1739

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyridines and derivatives Pyridinecarboxylic acids
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyridines and derivatives Pyridinecarboxylic acids and derivatives Pyridinecarboxylic acids

• 953780-42-2(5-fluoro-6-methoxypyridine-3-carboxylic acid)
• 886372-69-6(6-Ethoxy-5-fluoronicotinaldehyde)
• 884494-82-0(5-fluoro-2-methoxypyridine-3-carboxylic acid)
• 111374-71-1(3-Pyridinecarboxylicacid, 2-amino-5-fluoro-6-methoxy-, methyl ester)
• 1214363-86-6(Ethyl 5-fluoro-2-methoxynicotinate)
• 122433-52-7(Methyl 5-fluoro-2-methoxypyridine-3-carboxylate)
• 959616-64-9(methyl 2-chloro-5-fluoro-6-methoxypyridine-3-carboxylate)
• 959616-65-0(5-fluoro-6-methoxy-3-Pyridinemethanol)
• 639091-33-1(3-Pyridinecarboxylic acid, 6-[4-[(3-fluorophenyl)methoxy]phenoxy]-)
• 884494-73-9(5-fluoro-6-methoxypyridine-3-carbaldehyde)