- Preparation of (hetero)aroyl spiroketones as acetyl-CoA carboxylase inhibitors for treatment of obesity., World Intellectual Property Organization, , ,
Cas no 953409-99-9 (5-Bromo-1H-indazole-7-carboxylic acid)
953409-99-9 structure
Product Name:5-Bromo-1H-indazole-7-carboxylic acid
CAS No:953409-99-9
MF:C8H5BrN2O2
MW:241.041500806808
MDL:MFCD13177019
CID:1074904
PubChem ID:53408101
Update Time:2025-11-06
5-Bromo-1H-indazole-7-carboxylic acid Chemical and Physical Properties
Names and Identifiers
-
- 5-Bromo-1H-indazole-7-carboxylic acid
- 1H-Indazole-7-carboxylicacid,5-broMo-
- 5-Bromo-1H-indazole-7-carboxylic acid (ACI)
- SY035922
- SCHEMBL4501756
- DTXSID50696179
- 5-Bromo-1H-indazole-7-carboxylicAcid
- SCHEMBL25204244
- EN300-3080658
- HBCUQNYHXNSYGH-UHFFFAOYSA-N
- AS-8601
- AC-29555
- DA-17400
- AKOS023808239
- CS-0038921
- Z1269126743
- 953409-99-9
- P11591
- PB20772
- MFCD13177019
- 5-bromo-2H-indazole-7-carboxylic acid
-
- MDL： MFCD13177019
- Inchi： 1S/C8H5BrN2O2/c9-5-1-4-3-10-11-7(4)6(2-5)8(12)13/h1-3H,(H,10,11)(H,12,13)
- InChI Key： HBCUQNYHXNSYGH-UHFFFAOYSA-N
- SMILES： O=C(C1C2=C(C=NN2)C=C(Br)C=1)O
Computed Properties
- Exact Mass: 239.95344g/mol
- Monoisotopic Mass: 239.95344g/mol
- Isotope Atom Count: 0
- Hydrogen Bond Donor Count: 2
- Hydrogen Bond Acceptor Count: 4
- Heavy Atom Count: 13
- Rotatable Bond Count: 1
- Complexity: 224
- Covalently-Bonded Unit Count: 1
- Defined Atom Stereocenter Count: 0
- Undefined Atom Stereocenter Count : 0
- Defined Bond Stereocenter Count: 0
- Undefined Bond Stereocenter Count: 0
- XLogP3: 2.2
- Topological Polar Surface Area: 66?2
Experimental Properties
- Density: 1.946±0.06 g/cm3 (20 oC 760 Torr),
- Boiling Point: 486.9±30.0℃ at 760 mmHg
- Solubility: Very slightly soluble (0.46 g/l) (25 o C),
5-Bromo-1H-indazole-7-carboxylic acid Pricemore >>
| Related Categories | No. | Product Name | Cas No. | Purity | Specification | Price | update time | Inquiry |
|---|---|---|---|---|---|---|---|---|
| CHENG DOU FEI BO YI YAO Technology Co., Ltd. | MY0346-5g |
5-bromo-1H-indazole-7-carboxylic acid |
953409-99-9 | 95% | 5g |
$822 | 2023-09-07 | |
| TRC | B336500-10mg |
5-Bromo-1H-indazole-7-carboxylic Acid |
953409-99-9 | 10mg |
$ 50.00 | 2022-06-07 | ||
| TRC | B336500-50mg |
5-Bromo-1H-indazole-7-carboxylic Acid |
953409-99-9 | 50mg |
$ 115.00 | 2022-06-07 | ||
| TRC | B336500-100mg |
5-Bromo-1H-indazole-7-carboxylic Acid |
953409-99-9 | 100mg |
$ 160.00 | 2022-06-07 | ||
| Alichem | A269001979-250mg |
5-Bromo-1H-indazole-7-carboxylic acid |
953409-99-9 | 95% | 250mg |
$151.20 | 2023-08-31 | |
| Alichem | A269001979-1g |
5-Bromo-1H-indazole-7-carboxylic acid |
953409-99-9 | 95% | 1g |
$381.50 | 2023-08-31 | |
| Alichem | A269001979-5g |
5-Bromo-1H-indazole-7-carboxylic acid |
953409-99-9 | 95% | 5g |
$980.10 | 2023-08-31 | |
| NAN JING YAO SHI KE JI GU FEN Co., Ltd. | PBN2011166-1 G |
5-bromo-1H-indazole-7-carboxylic acid |
953409-99-9 | 97% | 1g |
￥ 1,214.00 | 2021-05-07 | |
| NAN JING YAO SHI KE JI GU FEN Co., Ltd. | PBN2011166-5 G |
5-bromo-1H-indazole-7-carboxylic acid |
953409-99-9 | 97% | 5g |
￥ 5,629.00 | 2021-05-07 | |
| NAN JING YAO SHI KE JI GU FEN Co., Ltd. | PBN2011166-10 G |
5-bromo-1H-indazole-7-carboxylic acid |
953409-99-9 | 97% | 10g |
￥ 9,471.00 | 2021-05-07 |
5-Bromo-1H-indazole-7-carboxylic acid Production Method
Production Method 1
Reaction Conditions
1.1 Reagents: Potassium hydroxide Solvents: Methanol , Water ; 0 °C; 2 d, rt
Reference
Production Method 2
Reaction Conditions
1.1 Reagents: Lithium hydroxide Solvents: Tetrahydrofuran , Water ; 4 h, rt → 50 °C
1.2 Reagents: Hydrochloric acid Solvents: Water ; pH 2
1.2 Reagents: Hydrochloric acid Solvents: Water ; pH 2
Reference
- Preparation of indazole derivatives as selective JAK1 (janus kinase 1) inhibitors, Korea, , ,
Production Method 3
Reaction Conditions
1.1 Reagents: Potassium hydroxide Solvents: Methanol , Tetrahydrofuran , Water ; 16 h, rt
1.2 Reagents: Hydrochloric acid Solvents: Water ; acidified
1.2 Reagents: Hydrochloric acid Solvents: Water ; acidified
Reference
- Orally Bioavailable Enzymatic Inhibitor of CD38, MK-0159, Protects against Ischemia/Reperfusion Injury in the Murine HeartLagu, Bharat; Wu, Xinyuan; Kulkarni, Santosh; Paul, Rakesh; Becherer, J. David; et al, Journal of Medicinal Chemistry, 2022, 65(13), 9418-9446
Production Method 4
Reaction Conditions
1.1 Reagents: Sodium carbonate Solvents: 1,4-Dioxane , Water ; 1 h, 25 °C
1.2 Reagents: Hydrochloric acid Solvents: Water ; pH 3
1.2 Reagents: Hydrochloric acid Solvents: Water ; pH 3
Reference
- Preparation of indazole compounds that inhibit one or more receptor, or non-receptor, tyrosine or serine/threonine kinase, World Intellectual Property Organization, , ,
5-Bromo-1H-indazole-7-carboxylic acid Raw materials
5-Bromo-1H-indazole-7-carboxylic acid Preparation Products
5-Bromo-1H-indazole-7-carboxylic acid Related Literature
-
Yang Chen,Di Zhou,Zheyi Meng,Jin Zhai Chem. Commun., 2016,52, 10020-10023
-
Jingquan Liu,Huiyun Liu,Zhongfan Jia,Volga Bulmus,Thomas P. Davis Chem. Commun., 2008, 6582-6584
-
3. An integrated chip for immunofluorescence and its application to analyze lysosomal storage disordersJie Shen,Ying Zhou,Tu Lu,Junya Peng,Zhixiang Lin,Yuhong Pang,Li Yu Lab Chip, 2012,12, 317-324
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Rongyan Guo,Tao Li,Shuie Shi J. Mater. Chem. C, 2019,7, 5148-5154
-
Priyambada Nayak,Tanmaya Badapanda,Anil Kumar Singh,Simanchalo Panigrahi RSC Adv., 2017,7, 16319-16331
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