Production Method 1

76-83-5

2075-45-8

95162-14-4

Reaction Conditions

1.1 Reagents: Sodium hydride Solvents: Tetrahydrofuran ,  Water ;  0 °C; overnight, rt
1.2 Reagents: Water ;  rt

Reference

Efficient and chromatography-free methodology for the modular synthesis of oligo-(1H-pyrazol-4-yl)-arenes with controllable size, shape and steric bulk

Kershaw Cook, Laurence J.; Kearsey, Rachel; Lamb, Jessica V.; Pace, Edward J.; Gould, Jamie A., Tetrahedron Letters, 2016, 57(8), 895-898

Production Method 2

76-83-5

2075-45-8

95162-14-4

Reaction Conditions

1.1 Reagents: Triethylamine Solvents: Ethanol ;  1 h, rt
1.2 Reagents: Water ;  rt

Reference

Synthesis of 4-aryl-1H-pyrazoles by Suzuki-Miyaura cross coupling reaction between 4-bromo-1H-1-tritylpyrazole and arylboronic acids

Ichikawa, Hayato; Nishioka, Miho; Arimoto, Masao; Usami, Yoshihide, Heterocycles, 2010, 81(6), 1509-1516

Production Method 3

519-73-3

2075-45-8

95162-14-4

Reaction Conditions

1.1 Reagents: tert-Butyl peroxybenzoate Catalysts: (OC-6-22)-Tris[5-fluoro-2-(2-pyridinyl-κN)phenyl-κC]iridium Solvents: 1,2-Dichloroethane ;  24 h, rt

Reference

Azolation of Benzylic C-H Bonds via Photoredox-Catalyzed Carbocation Generation

Das, Mrinmoy; Zamani, Leila; Bratcher, Christopher; Musacchio, Patricia Z., Journal of the American Chemical Society, 2023, 145(7), 3861-3868

Production Method 4

76-83-5

2075-45-8

95162-14-4

Reaction Conditions

1.1 Reagents: Triethylamine Solvents: Diethyl ether ;  3 h, rt

Reference

Scalable 9-Step Synthesis of the Splicing Modulator NVS-SM2

Abou-Hamdan, Hussein; Desaubry, Laurent, Journal of Organic Chemistry, 2018, 83(5), 2954-2958

Production Method 5

76-83-5

2075-45-8

95162-14-4

Reaction Conditions

1.1 Reagents: Sodium hydride Solvents: Tetrahydrofuran ;  0 °C; 90 min, 0 °C
1.2 36 h, 0 °C
1.3 Reagents: Water

Reference

Solvent-free synthesis of metal-organic frameworks using low-melting metal salts

Azbell, Tyler J.; Pitt, Tristan A.; Bollmeyer, Melissa M.; Cong, Christina; Lancaster, Kyle M.; et al, ChemRxiv, 2022, 1, 1-11

Production Method 6

76-83-5

2075-45-8

95162-14-4

Reaction Conditions

1.1 Reagents: Sodium hydride Solvents: Tetrahydrofuran ;  1 h, 0 °C
1.2 0 °C; 0 °C → rt; 16 h, rt
1.3 Reagents: Ethanol ;  0 °C

Reference

Synthesis of functionalized 5-(4-arylpiperazin-1-yl)-N-arylpentanamides and their evaluation as D3 receptor ligands

Blass, Benjamin E. ; Chen, Peng-Jen; Gordon, John C., Medicinal Chemistry Research, 2022, 31(5), 735-748

Production Method 7

76-83-5

2075-45-8

95162-14-4

Reaction Conditions

1.1 Reagents: Pyridine Catalysts: 4-(Dimethylamino)pyridine Solvents: Dichloromethane ;  overnight, rt

Reference

Pyrazole compounds as modulators of MAGL, ABHD6 and FAAH and methods of making and using same

, World Intellectual Property Organization, , ,

Production Method 8

76-83-5

2075-45-8

95162-14-4

Reaction Conditions

1.1 Reagents: Potassium carbonate Solvents: Dimethylformamide ;  40 h, rt

Reference

Preparation of pyrrole derivatives as androgen receptor antagonists for treatment of cancer

, World Intellectual Property Organization, , ,

Production Method 9

76-83-5

2075-45-8

95162-14-4

Reaction Conditions

1.1 Reagents: Pyridine Catalysts: 4-(Dimethylamino)pyridine Solvents: Pyridine ;  24 h, 80 °C

Reference

Preparation of substituted phthalazinamines as Aurora kinase modulators

, World Intellectual Property Organization, , ,

Production Method 10

76-83-5

2075-45-8

95162-14-4

Reaction Conditions

1.1 Reagents: Triethylamine Solvents: Dimethylformamide ;  0 °C; 2 d, rt

Reference

Preparation of N-(mercaptoacyl)phenylalanine derivatives as inhibitors of angiotensin converting enzyme (ACE) and/or neutral endopeptidase (NEP)

, World Intellectual Property Organization, , ,

Production Method 11

2206-53-3

2075-45-8

95162-14-4

Reaction Conditions

1.1 Reagents: Sodium hydride Solvents: Tetrahydrofuran ;  15 min, 0 °C; 1 h, 0 °C
1.2 15 min, 0 °C; 0 °C → rt; 24 h, rt

Reference

Evaluating the Robustness of Metal-Organic Frameworks for Synthetic Chemistry

Wang, Zihao; Bilegsaikhan, Arvin; Jerozal, Ronald T.; Pitt, Tristan A.; Milner, Phillip J., ACS Applied Materials & Interfaces, 2021, 13(15), 17517-17531

Production Method 12

76-83-5

2075-45-8

95162-14-4

Reaction Conditions

1.1 Reagents: Pyridine Catalysts: 4-(Dimethylamino)pyridine Solvents: Dichloromethane ;  16 h, rt

Reference

Preparation of pyrrolopyridines as Tec kinase inhibitors

, World Intellectual Property Organization, , ,

Production Method 13

76-83-5

2075-45-8

95162-14-4

Reaction Conditions

1.1 Reagents: Potassium tert-butoxide Solvents: Dimethylformamide ;  0 °C; 0 °C → rt; 1 h, rt

Reference

Inverse Electron Demand Diels-Alder Reactions of 1,2,3-Triazines: Pronounced Substituent Effects on Reactivity and Cycloaddition Scope

Anderson, Erin D.; Boger, Dale L., Journal of the American Chemical Society, 2011, 133(31), 12285-12292

Production Method 14

76-83-5

2075-45-8

95162-14-4

Reaction Conditions

1.1 Reagents: Triethylamine Solvents: Dimethylformamide ;  rt; 0 °C; 3 h, 70 °C

Reference

Preparation of pyridine derivatives substituted with heterocycle and phosphonoamino and antifungal agents containing the same

, World Intellectual Property Organization, , ,

Production Method 15

76-83-5

2075-45-8

95162-14-4

Reaction Conditions

1.1 Reagents: Potassium tert-butoxide Solvents: Dimethylformamide ;  0 °C; overnight, rt

Reference

Preparation of aryloxypyridinamines and related compounds as inhibitors of Notch signaling pathway and use thereof in treatment of cancers

, World Intellectual Property Organization, , ,

Production Method 16

76-83-5

2075-45-8

95162-14-4

Reaction Conditions

1.1 Reagents: Potassium tert-butoxide Solvents: Dimethylformamide ;  0 °C; 2 h, 0 °C → rt

Reference

Rhodium/Chiral Diene Complexes in the Catalytic Asymmetric Arylation of β-Pyrazol-1-yl Acrylates

Gopula, Balraj; Tsai, Yun-Fan; Kuo, Ting-Shen; Wu, Ping-Yu; Henschke, Julian P.; et al, Organic Letters, 2015, 17(5), 1142-1145

Production Method 17

76-83-5

2075-45-8

95162-14-4

Reaction Conditions

1.1 Reagents: Cesium carbonate Solvents: Dimethyl sulfoxide ;  rt; 2 h, 90 °C

Reference

Preparation of hetero-bifunctional pomalidomide derivatives as GSPT1 degraders for treatment of cancers

, World Intellectual Property Organization, , ,

Production Method 18

76-83-5

2075-45-8

95162-14-4

Reaction Conditions

1.1 Reagents: Potassium tert-butoxide Solvents: Dimethylformamide ;  0 °C; 0 °C → rt; 1 h, rt
1.2 Solvents: Water ;  rt
1.3 Reagents: Ammonium chloride Solvents: Water ;  neutralized, rt

Reference

Identification and Profiling of Hydantoins-A Novel Class of Potent Antimycobacterial DprE1 Inhibitors

Rogacki, Maciej K.; Pitta, Eleni; Balabon, Olga; Huss, Sophie; Lopez-Roman, Eva Maria; et al, Journal of Medicinal Chemistry, 2018, 61(24), 11221-11249

Production Method 19

76-83-5

2075-45-8

95162-14-4

Reaction Conditions

1.1 Reagents: Potassium tert-butoxide Solvents: Dimethylformamide ;  0 °C; 12 h, 28 °C

Reference

Pyrazolyl derivatives as SYK inhibitors and their preparation

, World Intellectual Property Organization, , ,

Production Method 20

76-83-5

2075-45-8

95162-14-4

Reaction Conditions

1.1 Reagents: Sodium hydride Solvents: Tetrahydrofuran ;  1 h, rt; 30 min, 0 °C; 30 min, rt
1.2 20 min, 0 °C; 3 h, rt
1.3 Reagents: Water ;  0 °C

Reference

Antifungal triazole derivatives, processes for preparing them, and pharmaceutical compositions containing them

, World Intellectual Property Organization, , ,

4-Bromo-1-trityl-1H-pyrazole Raw materials

• (chlorodiphenylmethyl)benzene
• Benzene,1,1',1''-(iodomethylidyne)tris-
• Triphenylmethane
• 4-Bromopyrazole

4-Bromo-1-trityl-1H-pyrazole Preparation Products

• 4-Bromo-1-trityl-1H-pyrazole (95162-14-4)

• 1. An insight into the hybridization mechanism of hairpin DNA physically immobilized on chemically modified graphenes
  Adeline Huiling Loo,Alessandra Bonanni,Martin Pumera Analyst, 2013,138, 467-471
• 2. An antioxidant self-healing hydrogel for 3D cell cultures?
  Lei Yang,Yuan Zeng,Haibo Wu,Chunwu Zhou,Lei Tao J. Mater. Chem. B, 2020,8, 1383-1388
• 3. An analysis of the WTC fires using CIB correlations and simple modeling
  JGQuintiere
• 4. An integrated cathode and solid electrolyte via in situ polymerization with significantly reduced interface resistance?
  Jialiang Yuan,Ran Dong,Yuan Li,Yang Liu,Zhuo Zheng,Yuxia Liu,Yan Sun,Benhe Zhong,Zhenguo Wu,Xiaodong Guo Chem. Commun., 2021,57, 13004-13007
• 5. An atom efficient route to N-aryl and N-alkyl pyrrolines by transition metal catalysis?
  Supaporn Sawadjoon,Joseph S. M. Samec Org. Biomol. Chem., 2011,9, 2548-2554

• Solvents and Organic Chemicals Organic Compounds Benzenoids Triphenyl compounds Triphenyl compounds
• Solvents and Organic Chemicals Organic Compounds Benzenoids Triphenyl compounds

• 60629-22-3(1H-PYRAZOLE, 1-([1,1'-BIPHENYL]-4-YLPHENYLMETHYL)-)
• 919802-98-5(4-Bromo-3,5-dimethyl-1-(triphenylmethyl)-1H-pyrazole)
• 95163-43-2(1-Trityl-1H-pyrazole)
• 1430751-66-8(4-bromo-1-(diphenylmethyl)-1H-Pyrazole)
• 870526-65-1(2H-Indazole, 4-bromo-2-(triphenylmethyl)-)
• 1340161-36-5(4-bromo-1-(1-phenylethyl)-1H-pyrazole)
• 191980-54-8(4-Iodo-1-trityl-1H-pyrazole)
• 50877-41-3(4-Bromo-1-(phenylmethyl)--1H-pyrazole)
• 512809-49-3(4-(4-bromo-1H-pyrazol-1-yl)methylaniline)
• 956440-92-9(3-((4-Bromo-1h-pyrazol-1-yl)methyl)aniline)