Production Method 1

1229616-47-0

951163-61-4

Reaction Conditions

1.1 Reagents: Benzylamine ,  Hydrogen ,  Ammonia Catalysts: Palladium Solvents: Methanol ;  80 psi, rt

Reference

Process for stereoselective synthesis of piperidine derivatives starting from dialdehydes or dinitriles via reductive amination/cyclization as key step

, United States, , ,

Production Method 2

951163-63-6

951163-61-4

Reaction Conditions

1.1 Reagents: Hydrogen Catalysts: Palladium dihydroxide Solvents: Ethanol ;  2 h, rt

Reference

Preparation of pyrrolopyrazinylureas as JAK kinase inhibitors for the treatment of autoimmune and inflammatory diseases

, World Intellectual Property Organization, , ,

Production Method 3

951163-63-6

951163-61-4

Reaction Conditions

1.1 Reagents: Hydrogen Catalysts: Palladium Solvents: Ethanol ,  Water ;  45 psi, rt → 45 °C

Reference

Treatment of antibiotic-resistant bacteria infection

, World Intellectual Property Organization, , ,

Production Method 4

951163-63-6

951163-61-4

Reaction Conditions

1.1 Reagents: Hydrogen Catalysts: Palladium Solvents: Ethanol ,  Water ;  310 kPa, rt → 45 °C; 310 kPa, 45 °C; 45 °C → rt

Reference

Process for preparation of quinolone intermediates

, China, , ,

Production Method 5

951163-63-6

951163-61-4

Reaction Conditions

1.1 Reagents: Hydrogen Catalysts: Palladium Solvents: Ethanol ;  45 psi, rt; 45 psi, rt → 45 °C; 45 °C → rt

Reference

Process for preparation of quinolinone derivatives

, China, , ,

Production Method 6

951163-61-4

Reaction Conditions

Reference

Pharmaceutical parenteral compositions containing (3s,5s)-7-[3-amino-5-methyl-pyridyl]-1-cyclopropyl-1,4-dihydro-8-methoxy-4-oxo-3-carboxylic acid and its application as antimicrobial agent

, China, , ,

Production Method 7

951163-61-4

Reaction Conditions

Reference

Antimicrobial parenteral formulation containing a quinolinonecarboxylic acid derivative

, United States, , ,

Production Method 8

951163-63-6

951163-61-4

Reaction Conditions

1.1 Reagents: Hydrogen Catalysts: Palladium Solvents: Ethanol ;  12 h, rt

Reference

Preparation of imidazo[1,5-b]pyridazine derivatives as Pim kinase inhibitors

, World Intellectual Property Organization, , ,

Production Method 9

1229616-47-0

951163-61-4

Reaction Conditions

1.1 Reagents: Benzylamine ,  Hydrogen ,  Ammonia Catalysts: Palladium Solvents: Methanol ;  80 psi, rt

Reference

Stereoselective synthesis of piperidine derivatives

, China, , ,

Production Method 10

951163-63-6

951163-61-4

Reaction Conditions

1.1 Reagents: Hydrogen Catalysts: Palladium dihydroxide Solvents: Ethanol ;  2 h, 1 atm, rt

Reference

Pyrrolo[2,3-b]pyrazine derivatives as inhibitors of janus kinase and their preparation and use in the treatment of autoimmune and inflammatory diseases

, United States, , ,

Production Method 11

1270019-95-8

951163-61-4

Reaction Conditions

1.1 Solvents: Acetone ,  Oxalic acid ;  rt; 0.5 h, rt; 1 h, rt → 0 °C
1.2 Reagents: Sodium hydroxide ;  pH 10
1.3 Reagents: (-)-Mandelic acid Solvents: Acetonitrile ;  1 h, rt; 1 h, rt → 0 °C
1.4 Reagents: Sodium hydroxide ;  pH 10

Reference

Preparation method of 3-substituted-5-aminopiperidine with protecting group

, China, , ,

Production Method 12

951163-63-6

951163-61-4

Reaction Conditions

1.1 Reagents: Hydrogen Catalysts: Palladium Solvents: Ethanol ,  Water ;  45 psi, rt → 45 °C

Reference

Antibacterial quinolone for Pneumonia treatment

, World Intellectual Property Organization, , ,

Production Method 13

951163-63-6

951163-61-4

Reaction Conditions

1.1 Reagents: Hydrogen Catalysts: Palladium Solvents: Ethanol ;  45 s, rt → 45 °C

Reference

Antimicrobial parenteral formulation containing a quinolinonecarboxylic acid derivative

, World Intellectual Property Organization, , ,

Production Method 14

951163-63-6

951163-61-4

Reaction Conditions

1.1 Reagents: Hydrogen Catalysts: Palladium Solvents: Ethanol ,  Water ;  45 psi, rt → 45 °C; 45 psi, 45 °C; 45 °C → rt

Reference

Process for preparation of malate salts and polycrystalline of (3S,5S)-7-(3-amino-5-methyl-piperidine-1-yl)-1-cyclopropyl-1,4-dihydro-8-methoxy-4-oxo-quinoline-3-carboxylic acid

, China, , ,

Production Method 15

951313-21-6

951163-61-4

Reaction Conditions

1.1 Reagents: Hydrogen Catalysts: Palladium Solvents: Ethanol ;  45 psi, rt → 45 °C; 45 °C → rt

Reference

Antibiotic compositions containing malate salts and polymorphs of (3s,5s)-7-[3-amino-5-methyl-piperidinyl]-1-cyclopropyl-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid

, World Intellectual Property Organization, , ,

Production Method 16

951163-63-6

951163-61-4

Reaction Conditions

1.1 Reagents: Hydrogen Catalysts: Palladium Solvents: Ethanol ;  45 psi, 45 °C

Reference

A hydride reduction process for preparing quinolone intermediates

, World Intellectual Property Organization, , ,

Production Method 17

951163-63-6

951163-61-4

Reaction Conditions

1.1 Reagents: Hydrogen Catalysts: Palladium Solvents: Ethanol ;  45 psi, rt → 45 °C

Reference

A coupling process for preparing quinolone intermediates

, World Intellectual Property Organization, , ,

tert-butyl N-[(3S,5S)-5-methylpiperidin-3-yl]carbamate Raw materials

• tert-butyl (3S,5S)-1-benzyl-5-methylpiperidin-3-ylcarbamate
• tert-butyl((1S,3S)-1,3-dicyanobutyl)carbamate
• Tert-Butyl (5-Methylpiperidin-3-Yl)Carbamate
• 1,1-Dimethylethyl N-[(3S,5S)-1-(hydroxymethyl)-5-methyl-3-piperidinyl]carbamate

tert-butyl N-[(3S,5S)-5-methylpiperidin-3-yl]carbamate Preparation Products

• tert-butyl N-[(3S,5S)-5-methylpiperidin-3-yl]carbamate (951163-61-4)

• 1. Emerging enantiomeric resolution materials with homochiral nano-fabrications
  Ji-Ping Wei Nanoscale, 2015,7, 11815-11832
• 2. Enabling shape memory and healable effects in a conjugated polymer by incorporating siloxane via dynamic imine bond?
  Yaling Zhang,Chunhui Dai,Shiwei Zhou,Bin Liu Chem. Commun., 2018,54, 10092-10095
• 3. Exciting clusters, what does off-resonance actually mean??
  Goonay Yousefalizadeh,Shideh Ahmadi,Nicholas J. Mosey,Kevin G. Stamplecoskie Nanoscale, 2021,13, 242-252
• 4. Fatty acid positional distribution in colostrum and mature milk of women living in Inner Mongolia, North Jiangsu and Guangxi of China?
  Long Deng,Qian Zou,Biao Liu,Wenhui Ye,Chengfei Zhuo,Li Chen,Ze-Yuan Deng,Ya-Wei Fan,Jing Li Food Funct., 2018,9, 4234-4245
• 5. Emergence of microfluidic wearable technologies
  Joo Chuan Yeo,Kenry Lab Chip, 2016,16, 4082-4090

• 250275-21-9(Carbamic acid,[(3S,4S)-4-methyl-3-piperidinyl]-, 1,1-dimethylethyl ester (9CI))
• 250275-22-0(Carbamic acid,[(3R,4R)-4-methyl-3-piperidinyl]-, 1,1-dimethylethyl ester (9CI))
• 250275-23-1(tert-butyl N-[trans-4-methyl-3-piperidyl]carbamate)
• 488728-06-9(tert-butyl N-[(3S,4S)-4-ethyl-3-piperidyl]carbamate)
• 488728-05-8(tert-butyl N-[(3S,4R)-4-ethyl-3-piperidyl]carbamate)
• 454709-84-3(tert-butyl N-(4-methylpiperidin-3-yl)carbamate)
• 1203651-07-3(tert-butyl N-[(3S,5R)-5-methylpiperidin-3-yl]carbamate)
• 1270019-92-5(tert-butyl N-[(3R,5S)-5-methylpiperidin-3-yl]carbamate)
• 250275-20-8(tert-butyl N-[cis-4-methylpiperidin-3-yl]carbamate)
• 169750-96-3(tert-butyl n-(3-methylpiperidin-3-yl)carbamate)