Production Method 1

867279-13-8

951030-56-1

Reaction Conditions

1.1 Reagents: Magnesate(1-), dichloro(1-methylethyl)-, lithium (1:1) Solvents: Tetrahydrofuran ;  0 °C; 1 h, 22 °C
1.2 40 min, 1 atm, 22 °C
1.3 Solvents: Water
1.4 Reagents: Hydrochloric acid Solvents: Water ;  pH 5

Reference

Preparation of substituted tetrahydroisoquinolines as PRMT5 inhibitors

, World Intellectual Property Organization, , ,

Production Method 2

850080-86-3

951030-56-1

Reaction Conditions

1.1 Reagents: Lithium hydroxide Solvents: Tetrahydrofuran ,  Water ;  2 h, rt
1.2 Reagents: Hydrochloric acid Solvents: Water ;  acidified, rt

Reference

Tetrazole containing apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof

, World Intellectual Property Organization, , ,

2-Chloro-5-methyl-isonicotinic acid Raw materials

• 4-bromo-2-chloro-5-methyl-pyridine
• ethyl 2-chloro-5-methylpyridine-4-carboxylate

2-Chloro-5-methyl-isonicotinic acid Preparation Products

• 2-Chloro-5-methyl-isonicotinic acid (951030-56-1)

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• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyridines and derivatives Pyridinecarboxylic acids
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyridines and derivatives Pyridinecarboxylic acids and derivatives Pyridinecarboxylic acids

• 874115-97-6(4-Pyridinecarboxylic acid, 2-chloro-, potassium salt)
• 243835-70-3(6-Chloropyridine-3,4-dicarboxylic Acid)
• 1289042-45-0(2-chloro-3-formylpyridine-4-carboxylic acid)
• 133928-73-1(2-Chloro-3-methylisonicotinic acid)
• 1256835-40-1(2,6-dichloro-3-methylisonicotinic acid)
• 5398-44-7(2,6-dichloropyridine-4-carboxylic acid)
• 6313-54-8(2-chloropyridine-4-carboxylic acid)
• 5326-23-8(6-chloropyridine-3-carboxylic acid)
• 503555-50-8(6-chloro-4-methylpyridine-3-carboxylic acid)
• 1031433-06-3(6-Chloro-4-formyl-nicotinic Acid)