Production Method 1

93683-65-9

95095-84-4

Reaction Conditions

1.1 Reagents: Sodium hydroxide Catalysts: Tetrabutylammonium bromide Solvents: Dichloromethane ,  Water ;  overnight, rt

Reference

4,6-Disubstituted pyrido[3,2-d]pyrimidine compound, its preparation and application in preparation of MNK inhibitor and drug for treating and/or preventing various cancers and/or metabolic diseases

, China, , ,

Production Method 2

93683-65-9

95095-84-4

Reaction Conditions

1.1 Reagents: Acetic acid Solvents: Water ;  20 min, rt
1.2 Reagents: Sodium dithionite ;  rt; 2 h, rt

Reference

Pyrido[3,2-d]pyrimidines as immunosuppressive agents, and their preparation, pharmaceutical compositions and use in medical treatment

, United States, , ,

Production Method 3

93683-65-9

95095-84-4

Reaction Conditions

1.1 Reagents: Acetic acid Solvents: Water ;  20 min, rt
1.2 Reagents: Sodium dithionite ;  rt; 2 h, rt

Reference

Preparation of pyrido(3,2-d)pyrimidines and use as immunosuppressive prodrugs

, World Intellectual Property Organization, , ,

Production Method 4

93683-65-9

95095-84-4

Reaction Conditions

1.1 Reagents: Iron ,  Hydrochloric acid Solvents: Methanol ,  Water ;  45 min, reflux
1.2 Reagents: Ammonium hydroxide Solvents: Water ;  basified

Reference

Cyclic regimens using cyclic urea and cyclic amide derivatives

, World Intellectual Property Organization, , ,

Production Method 5

93683-65-9

95095-84-4

Reaction Conditions

1.1 Reagents: Sodium dithionite Catalysts: Tetrabutylammonium bromide Solvents: Dichloromethane ,  Water ;  3 h, 30 °C

Reference

Synthesis and biological evaluation of substituted 1,2,3-benzotriazines and pyrido[3,2-d]-1,2,3-triazines as inhibitors of vascular endothelial growth factor receptor-2

Zhao, Xing-Wang; Liu, Dan; Luan, Sheng-Lin; Hu, Guo-Dong; Lv, Jin-Ling; et al, Bioorganic & Medicinal Chemistry, 2013, 21(24), 7807-7815

Production Method 6

93683-65-9

95095-84-4

Reaction Conditions

1.1 Reagents: Iron ,  Hydrochloric acid Solvents: Methanol ;  reflux

Reference

Pyrimidine derivatives, preparation, and therapeutic use

, United States, , ,

Production Method 7

93683-65-9

95095-84-4

Reaction Conditions

1.1 Reagents: Iron ,  Hydrochloric acid Solvents: Ethanol ,  Water ;  reflux; 30 min, reflux
1.2 Reagents: Water ;  cooled
1.3 Reagents: Ammonium hydroxide Solvents: Water ;  basified

Reference

Preparation of arenotriazine derivatives as tyrosine kinase inhibitors for treatment of cancer

, China, , ,

Production Method 8

93683-65-9

95095-84-4

Reaction Conditions

1.1 Reagents: Tetrabutylammonium bromide ,  Sodium dithionite Solvents: Dichloromethane ,  Water ;  overnight, rt

Reference

Optimization of 4,6-Disubstituted Pyrido[3,2-d]pyrimidines as Dual MNK/PIM Inhibitors to Inhibit Leukemia Cell Growth

Han, Yu; Zhang, Huimin; Wang, Shuxiang; Li, Bo; Xing, Kun; et al, Journal of Medicinal Chemistry, 2021, 64(18), 13719-13735

Production Method 9

93683-65-9

95095-84-4

Reaction Conditions

1.1 Reagents: Acetic acid Solvents: Water ;  20 min, rt
1.2 Reagents: Sodium dithionite ;  rt; 2 h, rt

Reference

Preparation of pyrido[3,2-d]pyrimidines for treating hepatitis C infection

, World Intellectual Property Organization, , ,

Production Method 10

93683-65-9

95095-84-4

Reaction Conditions

1.1 Reagents: Stannous chloride Solvents: Ethanol ;  2 h, reflux

Reference

Substituted azaquinazolinones as modulators of GHSr-1a for the treatment of type II diabetes and obesity

Hanrahan, Patrick; Bell, James; Bottomley, Gillian; Bradley, Stuart; Clarke, Phillip; et al, Bioorganic & Medicinal Chemistry Letters, 2012, 22(6), 2271-2278

Production Method 11

93683-65-9

95095-84-4

Reaction Conditions

1.1 Reagents: Iron ,  Hydrochloric acid Solvents: Methanol ;  45 min, reflux
1.2 Reagents: Ammonium hydroxide Solvents: Water ;  basified

Reference

Preparation of cyclic urea and cyclic amide derivatives as agonists and antagonists of the progesterone receptor

, World Intellectual Property Organization, , ,

Production Method 12

93683-65-9

95095-84-4

Reaction Conditions

1.1 Reagents: Acetic acid ,  Sodium dithionite Solvents: Water ;  20 °C; 12 h, 60 °C

Reference

6-Heterocycloalkylquinazoline derivatives as anticancer agents and their preparation

, World Intellectual Property Organization, , ,

Production Method 13

93683-65-9

95095-84-4

Reaction Conditions

1.1 Reagents: Sodium thiosulfate Solvents: Dichloromethane ,  Water ;  3.5 h, rt
1.2 Reagents: Potassium carbonate Solvents: Water ;  30 min, neutralized, rt

Reference

Design and synthesis of substituted pyrido[3,2-d]-1,2,3-triazines as potential Pim-1 inhibitors

Fan, Yin-Bo; Li, Kun; Huang, Min; Cao, Yu; Li, Ying; et al, Bioorganic & Medicinal Chemistry Letters, 2016, 26(4), 1224-1228

Production Method 14

93683-65-9

95095-84-4

Reaction Conditions

Reference

Synthesis and antimalarial properties of 2,4-diamino-6-[(aryl)thio, sulfinyl, and sulfonyl]pyrido[3,2-d]pyrimidines

Colbry, Norman L.; Elslager, Edward F.; Werbel, Leslie M., Journal of Heterocyclic Chemistry, 1984, 21(5), 1521-5

Production Method 15

93683-65-9

95095-84-4

Reaction Conditions

1.1 Reagents: Iron ,  Hydrochloric acid Solvents: Ethanol ,  Water ;  rt; 30 min, reflux
1.2 Reagents: Sodium bicarbonate Solvents: Water ;  basified

Reference

Preparation of cyclohexylpyridine derivatives with NK1 receptor antagonistic action and suppressed CYP3A4 inhibitory action, and pharmaceutical compositions containing them

, World Intellectual Property Organization, , ,

Production Method 16

93683-65-9

95095-84-4

Reaction Conditions

1.1 Reagents: Iron ,  Hydrochloric acid Solvents: Ethanol ,  Water ;  rt; 10 min, rt → reflux

Reference

Preparation of (carboxymethyl)piperidine derivatives as NK1 receptor antagonists for treatment and prevention of antitumor agent-induced nausea and vomiting

, World Intellectual Property Organization, , ,

Production Method 17

93683-65-9

95095-84-4

Reaction Conditions

1.1 Reagents: Iron ,  Hydrochloric acid Solvents: Methanol ;  reflux

Reference

Preparation of pyrrolopyrimidines, furopyrimidines, pyridopyrimidines, and related compounds as inhibitors of dihydrofolate reductase and thymidylate synthase.

, United States, , ,

Production Method 18

95095-84-4

Reaction Conditions

Reference

Pyrazole-containing derivative, pharmaceutically acceptable salt thereof, preparation method therefor and application thereof

, World Intellectual Property Organization, , ,

Production Method 19

95095-84-4

Reaction Conditions

Reference

Preparation of pyrido[3,2-d]pyrimidines as immunosuppressive agents

, World Intellectual Property Organization, , ,

3-Amino-6-chloropyridine-2-carbonitrile Raw materials

• 6-chloro-3-nitro-pyridine-2-carbonitrile

3-Amino-6-chloropyridine-2-carbonitrile Preparation Products

• 3-Amino-6-chloropyridine-2-carbonitrile (95095-84-4)

• 1. Enabling chloride salts for thermal energy storage: implications of salt purity?
  J. Matthew Kurley,Phillip W. Halstenberg,Abbey McAlister,Stephen Raiman,Richard T. Mayes RSC Adv., 2019,9, 25602-25608
• 2. Examination of deposit in commercial diluted phosphoric acid
  Analyst, 1880,5, 146-147
• 3. Excimer emission and magnetoluminescence of radical-based zinc(ii) complexes doped in host crystals?
  Shojiro Kimura,Tetsuro Kusamoto Chem. Commun., 2020,56, 11195-11198
• 4. EWOD-driven droplet microfluidic device integrated with optoelectronic tweezers as an automated platform for cellular isolation and analysis?
  Gaurav J. Shah,Eric P.-Y. Chiou,Ming C. Wu,Chang-Jin “CJ” Kim Lab Chip, 2009,9, 1732-1739
• 5. Fate of single walled carbon nanotubes in wetland ecosystems?
  Joseph H. Bisesi,Tara Sabo-Attwood Environ. Sci.: Nano, 2014,1, 574-583

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyridines and derivatives Aminopyridines and derivatives
• Solvents and Organic Chemicals Organic Compounds cyanides/Cyanides

• 164666-68-6(6-chloro-2-methylpyridin-3-amine)
• 1104380-99-5(3-Amino-6-chloro-4-methylamino-pyridine-2-carbonitrile)
• 1206249-10-6(4-Amino-6-chloropicolinonitrile)
• 1805324-69-9(3-Amino-6-chloro-2-cyano-4-(difluoromethyl)pyridine)
• 1402834-69-8(2-Pyridinecarbonitrile, 5-amino-6-chloro-)
• 408538-29-4(3-amino-5-chloropyridine-2-carbonitrile)
• 42242-11-5(3-aminopyridine-2-carbonitrile)
• 945593-38-4(3,4-diamino-6-chloropyridine-2-carbonitrile)
• 1073182-86-1(3-Amino-4,6-dichloropicolinonitrile)
• 1772585-30-4(3-Amino-4-bromo-6-chloro-2-pyridinecarbonitrile)